{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T11:03:13Z","timestamp":1785409393870,"version":"3.56.0"},"reference-count":37,"publisher":"American Physiological Society","issue":"6","funder":[{"DOI":"10.13039\/100000027","name":"HHS | NIH | National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["R01AA026603"],"award-info":[{"award-number":["R01AA026603"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"published-print":{"date-parts":[[2025,6,1]]},"abstract":"<jats:p>Integrated stress response (ISR) activation contributes to palmitate-induced lipotoxicity in hepatocytes. mTORC1 acts as an upstream kinase essential for palmitate-mediated ISR activation and hepatocyte death. The formation of saturated phosphatidic acid mechanistically regulates hepatic mTORC1 activation induced by palmitate. Glucose-enhanced generation of saturated phosphatidic acid amplifies palmitate-induced hepatotoxicity, contributing to glucolipotoxicity.<\/jats:p>","DOI":"10.1152\/ajpgi.00027.2025","type":"journal-article","created":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T04:20:22Z","timestamp":1744863622000},"page":"G663-G676","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Saturated phosphatidic acids induce mTORC1-driven integrated stress response contributing to glucolipotoxicity in hepatocytes"],"prefix":"10.1152","volume":"328","author":[{"given":"Rui","family":"Guo","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02mpq6x41","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Illinois Chicago","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhui","family":"Li","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02mpq6x41","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Illinois Chicago","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuwei","family":"Jiang","sequence":"additional","affiliation":[{"name":"University of Illinois Chicago","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4398-8798","authenticated-orcid":false,"given":"Md. Wasim","family":"Khan","sequence":"additional","affiliation":[{"name":"University of Illinois Chicago","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2176-5654","authenticated-orcid":false,"given":"Brian T.","family":"Layden","sequence":"additional","affiliation":[{"name":"University of Illinois Chicago","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8750-5762","authenticated-orcid":false,"given":"Zhenyuan","family":"Song","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02mpq6x41","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Illinois Chicago","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11050844"},{"key":"B2","first-page":"17","author":"Prentki M","year":"1998","journal-title":"Journ Annu Diabetol Hotel Dieu"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2009.10.006"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsx.2020.09.026"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2009.10.012"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2019-00160"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1177\/1535370220928276"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.13636"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1126\/science.aat5314"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/nlz129"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a032870"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2023.1112253"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.02.004"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2010.09.026"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.202208103"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00165.2020"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00195.2021"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a040576"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2018.00010"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/0076-6879(83)98152-1"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2011.09.022"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00163.2022"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-012-1252-6"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-017-0014-2"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-031-63657-8_14"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1210\/er.2007-0023"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.2337\/db23-0171"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2023.2200625"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2023.01.001"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2018.8919"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.63326"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2014.162"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2008.10.010"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2020.101105"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA119.010892"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2017.04.007"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0004954"}],"container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpgi.00027.2025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T12:20:22Z","timestamp":1749644422000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpgi.00027.2025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,1]]},"references-count":37,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6,1]]}},"alternative-id":["10.1152\/ajpgi.00027.2025"],"URL":"https:\/\/doi.org\/10.1152\/ajpgi.00027.2025","relation":{},"ISSN":["0193-1857","1522-1547"],"issn-type":[{"value":"0193-1857","type":"print"},{"value":"1522-1547","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,1]]},"assertion":[{"value":"2025-01-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-28","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}