{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T08:15:37Z","timestamp":1788336937107,"version":"build-2803163510"},"reference-count":29,"publisher":"American Physiological Society","issue":"6","funder":[{"DOI":"10.13039\/501100001809","name":"National Nature Science Foundation of China","doi-asserted-by":"crossref","award":["30973137"],"award-info":[{"award-number":["30973137"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Nature Science Foundation of China","doi-asserted-by":"crossref","award":["81270481"],"award-info":[{"award-number":["81270481"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"published-print":{"date-parts":[[2016,12,1]]},"abstract":"<jats:p>\n                    Biliary atresia (BA) is characterized by progressive inflammation of the biliary system leading to liver cirrhosis, necessitating liver transplantation in pediatric patients. Various cell types have been reported to participate in the proinflammatory response in rhesus rotavirus (RRV)-induced BA mouse models, including T helper (Th) 1, Th2, Th17, CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells, and natural killer cells. The immune suppressive regulatory T (Treg) cells, on the contrary, were reported not to function properly. The underlying mechanism is largely unknown. Focusing on the impaired suppressive function of Treg, we found methylation status of CpG islands within the Foxp3 promoter region of Treg cells in BA patients and murine models were both increased. Moreover, by injecting 5-aza-2\u2032-deoxycytidine (Aza) as DNA-methylation inhibitor to RRV-infected mice, BA phenotypes were alleviated. Furthermore, Treg cells isolated from \u201cRRV+Aza\u201d-injected mice had better suppressive function than Treg cells from mice injected with RRV only, both in vivo and ex vivo. Thus we concluded that aberrant increased methylation status of \u201cFoxp3 promoter\u201d in Treg cells leads to impaired Treg suppressive function, exacerbating inflammatory injury in BA.\n                  <\/jats:p>","DOI":"10.1152\/ajpgi.00032.2016","type":"journal-article","created":{"date-parts":[[2016,9,22]],"date-time":"2016-09-22T23:08:46Z","timestamp":1474585726000},"page":"G989-G997","source":"Crossref","is-referenced-by-count":27,"title":["Foxp3 promoter methylation impairs suppressive function of regulatory T cells in biliary atresia"],"prefix":"10.1152","volume":"311","author":[{"given":"Kang","family":"Li","sequence":"first","affiliation":[{"name":"Department of Pediatric Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Union Hospital, Tongji 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