{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T04:07:49Z","timestamp":1793333269237,"version":"4.5.0"},"reference-count":59,"publisher":"American Physiological Society","issue":"6","funder":[{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["NIH DK057236"],"award-info":[{"award-number":["NIH DK057236"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000097","name":"HHS | NIH | National Center for Research Resources","doi-asserted-by":"publisher","award":["1 S10 RR16871"],"award-info":[{"award-number":["1 S10 RR16871"]}],"id":[{"id":"10.13039\/100000097","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["P20GM130459"],"award-info":[{"award-number":["P20GM130459"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"published-print":{"date-parts":[[2025,6,1]]},"abstract":"<jats:p> The physiological roles of interstitial cells of Cajal (ICC) throughout the gastrointestinal (GI) tract have been derived predominantly from studies of mice. We sought to determine whether reduction in ICC in the rat, a commonly used animal for studies of GI motor functions, leads to functional deficits. Ws\/Ws rats display reduced ICC leading to a disruption in pacemaker activity and neuroeffector responses. Our results provide additional evidence for the functions of ICC in the GI tract. <\/jats:p>","DOI":"10.1152\/ajpgi.00036.2025","type":"journal-article","created":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T06:49:41Z","timestamp":1744786181000},"page":"G677-G695","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["Functional roles of interstitial cells of Cajal in the GI tract of rats"],"prefix":"10.1152","volume":"328","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7571-7650","authenticated-orcid":false,"given":"Sung Jin","family":"Hwang","sequence":"first","affiliation":[{"name":"University of Nevada School of Medicine","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3392-785X","authenticated-orcid":false,"given":"Joong Goo","family":"Kwon","sequence":"additional","affiliation":[{"name":"University of Nevada School of Medicine","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8256-0375","authenticated-orcid":false,"given":"Elizabeth A. H.","family":"Beckett","sequence":"additional","affiliation":[{"name":"University of Nevada School of Medicine","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minkyung","family":"Kim","sequence":"additional","affiliation":[{"name":"University of Nevada School of Medicine","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Herbert","sequence":"additional","affiliation":[{"name":"University of Nevada School of Medicine","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4196-1583","authenticated-orcid":false,"given":"Kenton M.","family":"Sanders","sequence":"additional","affiliation":[{"name":"University of Nevada School of Medicine","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0217-1535","authenticated-orcid":false,"given":"Sean M.","family":"Ward","sequence":"additional","affiliation":[{"name":"University of Nevada School of Medicine","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00037.2013"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.21.12008"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-04-01393.2000"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2006.117390"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2006.122473"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2006.105189"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0503628102"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12059"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1007\/s004290100184"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-002-0261-x"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1242\/dev.116.2.369"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1007\/BF00304515"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.20929"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1990.tb08305.x"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90326-t"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.11.4671"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1994.sp020343"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1038\/373347a0"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1995.269.6.C1577"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2982.1998.00082.x"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2002.021915"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2003.050419"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2002.033365"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms2626"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V78.8.1942.1942"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1007\/s004410051119"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1007\/s004410000333"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1002\/cne.20746"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2004.063016"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1999.0235o.x"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-003-0323-8"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00194.2023"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00062.2016"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2013.264747"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2011.224634"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00001.2013"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(95)90333-x"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.1998.tb03850.x"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00136.2006"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1186\/s12929-020-00673-8"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1186\/s41021-016-0072-6"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1016\/j.trre.2014.05.002"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00074.2009"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-012-1468-7"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1113\/JP277335"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1007\/s004410050859"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202400982R"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00118.2009"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1007\/s004180050288"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-002-0657-1"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2012.01975.x"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.14670\/HH-19.1153"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1016\/s0016-5085(98)70198-2"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.49.10.1731"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2010.196030"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00080.2014"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2010.201129"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1113\/JP287315"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2012.168"}],"container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpgi.00036.2025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T16:20:23Z","timestamp":1749658823000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpgi.00036.2025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,1]]},"references-count":59,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6,1]]}},"alternative-id":["10.1152\/ajpgi.00036.2025"],"URL":"https:\/\/doi.org\/10.1152\/ajpgi.00036.2025","relation":{},"ISSN":["0193-1857","1522-1547"],"issn-type":[{"value":"0193-1857","type":"print"},{"value":"1522-1547","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,1]]},"assertion":[{"value":"2025-02-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-10","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}