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Here, we identify circRET as a translational regulator of RET. circRET is downregulated in HSCR tissues and modulates RET protein by directly binding RET mRNA without affecting mRNA levels. Loss of circRET suppresses RET\/AKT signaling and ENCC migration, highlighting a novel regulatory mechanism with therapeutic relevance.<\/jats:p>","DOI":"10.1152\/ajpgi.00041.2026","type":"journal-article","created":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T15:53:33Z","timestamp":1781193213000},"page":"G73-G84","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["circRET-mediated regulation of\n                    <i>RET<\/i>\n                    influences enteric neural crest cell development in Hirschsprung disease"],"prefix":"10.1152","volume":"331","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-8055-2335","authenticated-orcid":false,"given":"Yingnan","family":"Yan","sequence":"first","affiliation":[{"name":"Shanghai Jiao Tong University","place":["People\u2019s Republic of China"]},{"name":"Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition","place":["People\u2019s Republic of 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