{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T02:49:08Z","timestamp":1791254948723,"version":"4.1.0"},"reference-count":83,"publisher":"American Physiological Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"published-print":{"date-parts":[[2011,9]]},"abstract":"<jats:p> Integrins and other cell adhesion molecules regulate numerous physiological and pathological mechanisms by mediating the interaction between cells and their extracellular environment. Although the significance of integrins in the evolution and progression of certain cancers is well recognized, their involvement in nonmalignant processes, such as organ fibrosis or inflammation, is only beginning to emerge. However, accumulating evidence points to an instrumental role of integrin-mediated signaling in a variety of chronic and acute noncancerous diseases, particularly of the liver. <\/jats:p>","DOI":"10.1152\/ajpgi.00050.2011","type":"journal-article","created":{"date-parts":[[2011,6,10]],"date-time":"2011-06-10T04:58:39Z","timestamp":1307681919000},"page":"G425-G434","source":"Crossref","is-referenced-by-count":89,"title":["Role of integrins in fibrosing liver diseases"],"prefix":"10.1152","volume":"301","author":[{"given":"Eleonora","family":"Patsenker","sequence":"first","affiliation":[{"name":"Department of Visceral Surgery and Medicine, Inselspital, University of Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Stickel","sequence":"additional","affiliation":[{"name":"Department of Visceral Surgery and Medicine, Inselspital, University of Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2009.00956.x"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23591"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2008.08.008"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1172\/JCI24282"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1995.tb01504.x"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510250214"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.20.6.1467"},{"key":"B8","first-page":"74","volume":"2","author":"Bruck R","year":"2000","journal-title":"Isr Med Assoc J"},{"key":"B9","first-page":"391","volume":"70","author":"Bruck R","year":"1997","journal-title":"Yale J Biol Med"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1136\/gut.33.2.268"},{"key":"B11","first-page":"1920","volume":"88","author":"Chedid A","year":"1993","journal-title":"Am J Gastroenterol"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1126\/science.7716514"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1002\/med.2610140203"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20235"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2748"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2008.05.010"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1021\/jm020033k"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20974"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0831128100"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1126\/science.285.5430.1028"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cellbio.19.031103.133334"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2001.24231"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2003.50341"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200102083440604"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.08.040190.002053"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.2.1055"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2010.01072.x"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2010.03.015"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2004.08.001"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1097\/00041552-200205000-00005"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00442.2007"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2009.129"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00458.2005"},{"key":"B34","first-page":"1049","volume":"14","author":"Kotoh K","year":"2004","journal-title":"Int J Mol Med"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65066-3"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2000.8559"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.25.022106.141618"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2006.08.005"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(03)00161-2"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.10321"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200109100"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22413"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80545-0"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2008.05.023"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2006.07.030"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1002\/path.964"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v12.i38.6193"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.04.009"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23144"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2006.11.011"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(10)60140-7"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-199907000-00015"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2007.11.021"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23123"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.01.039"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.33023"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0020169"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.49.30911"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1080\/00952990701407702"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-010-9211-x"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1016\/S1542-3565(04)00445-8"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cellbio.12.1.697"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1999.tb04124.x"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60383-9"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1016\/j.gcb.2009.07.021"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1055\/s-2001-17556"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0904160"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1023\/A:1015345825025"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.018945"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2010.04.025"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(91)90478-4"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21849"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1093\/alcalc\/28.Supplement_1A.37"},{"key":"B74","first-page":"119","volume":"88","author":"Yang CQ","year":"2008","journal-title":"Zhonghua Yi Xue Za Zhi"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711750310"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(200001)190:1<93::AID-PATH507>3.0.CO;2-A"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23168"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21315"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1994.2079"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M605621200"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M311668200"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-006-1400-0"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M807408200"}],"container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajpgi.00050.2011","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T22:57:08Z","timestamp":1567983428000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajpgi.00050.2011"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9]]},"references-count":83,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,9]]}},"alternative-id":["10.1152\/ajpgi.00050.2011"],"URL":"https:\/\/doi.org\/10.1152\/ajpgi.00050.2011","relation":{},"ISSN":["0193-1857","1522-1547"],"issn-type":[{"value":"0193-1857","type":"print"},{"value":"1522-1547","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,9]]}}}