{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T23:47:16Z","timestamp":1791935236945,"version":"4.3.4"},"reference-count":80,"publisher":"American Physiological Society","issue":"3","funder":[{"DOI":"10.13039\/100000062","name":"HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01DK132781"],"award-info":[{"award-number":["R01DK132781"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"HHS | NIH | National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["R01GM143428"],"award-info":[{"award-number":["R01GM143428"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"published-print":{"date-parts":[[2025,9,1]]},"abstract":"<jats:p>Our study reveals a novel link between primary cilia and DNA repair in cholangiocytes. We show that DNA damage response (DDR) and repair proteins localize to cilia, and deciliation impairs survival and induces S-phase arrest under genotoxic stress. Deciliated cells exhibit increased DNA damage after cisplatin, irradiation, or methyl methanesulfonate (MMS) challenge. Following irradiation, Ataxia Telangiectasia Mutated protein (ATM), p53, and p21 are downregulated in deciliated cells. Similarly, IFT88 knockout mice show heightened DNA damage, highlighting the role of primary cilia in genome stability.<\/jats:p>","DOI":"10.1152\/ajpgi.00055.2025","type":"journal-article","created":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T00:40:39Z","timestamp":1755045639000},"page":"G469-G483","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Cholangiocytes\u2019 primary cilia regulate DNA damage response and repair"],"prefix":"10.1152","volume":"329","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5226-9747","authenticated-orcid":false,"given":"Estanislao","family":"Peixoto","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/017zqws13","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Minnesota","place":["United States"]},{"id":[{"id":"https:\/\/ror.org\/017zqws13","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Minnesota","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3505-6616","authenticated-orcid":false,"given":"Kishor","family":"Pant","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/017zqws13","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Minnesota","place":["United States"]},{"id":[{"id":"https:\/\/ror.org\/017zqws13","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Minnesota","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1143-7334","authenticated-orcid":false,"given":"Seth","family":"Richard","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/017zqws13","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Minnesota","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Pablo","family":"Popoca","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/017zqws13","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Minnesota","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9074-4307","authenticated-orcid":false,"given":"Juan E.","family":"Abrahante","sequence":"additional","affiliation":[{"name":"University of Minnesota","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2368-1131","authenticated-orcid":false,"given":"Wioletta","family":"Czaja","sequence":"additional","affiliation":[{"name":"The University of Alabama","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1753-3634","authenticated-orcid":false,"given":"Sergio A.","family":"Gradilone","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/017zqws13","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Minnesota","place":["United States"]},{"id":[{"id":"https:\/\/ror.org\/017zqws13","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Minnesota","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2008.09.011"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2016.51"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.03.026"},{"key":"B4","first-page":"251","volume":"2","author":"Ayala D","year":"2008","journal-title":"Gastrointest Cancer Res"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-020-0310-z"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.90265.2008"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.21530"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-12-2938"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29832"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2013.11.005"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2018.11.035"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.MCR-17-0034"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0909900107"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00033.2020"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1002\/hep.32080"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1186\/s13630-016-0040-6"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1126\/science.271.5256.1744"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/s1097-2765(00)80466-9"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1627708"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.06.028"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.3390\/cells10030507"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2013.08.006"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-020-00713-8"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.3967\/bes2022.058"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2006.11.033"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-2772-2_8"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1039\/d2fo03138h"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00126.2023"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1509249112"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.31113"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2024.04.010"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1097\/HEP.0000000000001055"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1007\/BF02621273"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e06-02-0133"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1002\/glia.23957"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.12463"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2019.02.043"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btae338"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.TIR120.002155"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.10.018"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1016\/j.clon.2013.06.007"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gki168"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21239248"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1007\/BF02623562"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-679X(08)94007-3"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.4161\/15384101.2015.945868"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrfmmm.2013.07.007"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1016\/s0968-0004(98)01232-8"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-169X.1984.00555.x"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-11-3596"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1038\/nature13441"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1038\/srep23899"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00381.2017"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1126\/science.8191288"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.77201"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1126\/science.270.5243.1842"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30308"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1093\/mutage\/14.5.497"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/14.5.919"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1667\/0033-7587(2001)156[0365:tlkmod]2.0.co;2"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1080\/09553002.2024.2445581"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.23.7.2451-2462.2003"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2000.3801"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.21195"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gki190"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1416418112"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1093\/jmcb\/mjac049"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1101\/gad.349596.122"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2013.05.023"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00672.2020"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.12334"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1016\/s1535-6108(03)00021-7"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2012.01.003"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1166\/jbn.2019.2664"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1016\/j.dnarep.2017.01.003"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.3390\/cancers7030839"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1002\/hep.32298"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30210"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddz232"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2021.01.011"}],"container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpgi.00055.2025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T14:22:40Z","timestamp":1757859760000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpgi.00055.2025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,1]]},"references-count":80,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,9,1]]}},"alternative-id":["10.1152\/ajpgi.00055.2025"],"URL":"https:\/\/doi.org\/10.1152\/ajpgi.00055.2025","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2025.01.28.635267","asserted-by":"object"}]},"ISSN":["0193-1857","1522-1547"],"issn-type":[{"value":"0193-1857","type":"print"},{"value":"1522-1547","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,1]]},"assertion":[{"value":"2025-02-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-23","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}