{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T14:36:45Z","timestamp":1788791805724,"version":"build-2803163510"},"reference-count":66,"publisher":"American Physiological Society","issue":"2","funder":[{"DOI":"10.13039\/100000062","name":"HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01DK115950"],"award-info":[{"award-number":["R01DK115950"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"HHS | NIH | National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1TR002377"],"award-info":[{"award-number":["UL1TR002377"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"published-print":{"date-parts":[[2022,8,1]]},"abstract":"<jats:p> This study compares gene expression in mucosa of the terminal ileum, right colon, and left colon in patients with diarrhea- or constipation-predominant irritable bowel syndrome (IBS) and contrasts expression between these two disease entities and also between each entity and mucosa from healthy controls. The study shows there is differential expression of genes related to immune, transmitter, nociceptive, ion channel, and transporter functions, as well as reduced serine protease inhibition, in patients with IBS. <\/jats:p>","DOI":"10.1152\/ajpgi.00063.2022","type":"journal-article","created":{"date-parts":[[2022,5,3]],"date-time":"2022-05-03T12:01:12Z","timestamp":1651579272000},"page":"G88-G101","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["Differential mRNA expression in ileal and colonic biopsies in irritable bowel syndrome with diarrhea or constipation"],"prefix":"10.1152","volume":"323","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6472-7514","authenticated-orcid":true,"given":"Michael","family":"Camilleri","sequence":"first","affiliation":[{"name":"Clinical Enteric Neuroscience Translational and Epidemiology Research (C.E.N.T.E.R.), Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yorick","family":"Magnus","sequence":"additional","affiliation":[{"name":"Clinical Enteric Neuroscience Translational and Epidemiology Research (C.E.N.T.E.R.), Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Carlson","sequence":"additional","affiliation":[{"name":"Clinical Enteric Neuroscience Translational and Epidemiology Research (C.E.N.T.E.R.), Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao Jing","family":"Wang","sequence":"additional","affiliation":[{"name":"Clinical Enteric Neuroscience Translational and Epidemiology Research (C.E.N.T.E.R.), Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Chedid","sequence":"additional","affiliation":[{"name":"Clinical Enteric Neuroscience Translational and Epidemiology Research (C.E.N.T.E.R.), Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Maselli","sequence":"additional","affiliation":[{"name":"Clinical Enteric Neuroscience Translational and Epidemiology Research (C.E.N.T.E.R.), Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann","family":"Taylor","sequence":"additional","affiliation":[{"name":"Clinical Enteric Neuroscience Translational and Epidemiology Research (C.E.N.T.E.R.), Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanna","family":"McKinzie","sequence":"additional","affiliation":[{"name":"Clinical Enteric Neuroscience Translational and Epidemiology Research (C.E.N.T.E.R.), Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nagaswaroop","family":"Kengunte Nagaraj","sequence":"additional","affiliation":[{"name":"Department of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Busciglio","sequence":"additional","affiliation":[{"name":"Clinical Enteric Neuroscience Translational and Epidemiology Research (C.E.N.T.E.R.), Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asha","family":"Nair","sequence":"additional","affiliation":[{"name":"Department of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1207068"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31548-8"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2007.11.012"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2007.140806"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00294.2012"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2016.118"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2011.257"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2014.09.037"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2016.05.002"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2016-312094"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.5009\/gnl14319"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-011-1827-3"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2011.01841.x"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.03.013"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.11.020"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2012.01902.x"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00153.2011"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.03.032"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12473"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13688"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0085073"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-016-4211-5"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2013.371"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v24.i1.46"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v25.i2.269"},{"key":"B26","first-page":"2238","volume":"7","author":"Qin B","year":"2014","journal-title":"Int J Clin Exp Pathol"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12811"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13232"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12860"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.14309\/ctg.0000000000000019"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1097\/00029330-200702020-00011"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2013-304570"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12358"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-12-91"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2011.423"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0042777"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2016.223"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.5056\/jnm20205"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/9624702"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1136\/gut.52.4.523"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1017\/S003118201300173X"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.5152\/tjg.2020.19856"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00288.2017"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00080.2015"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00068.2014"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.14309\/ctg.0000000000000329"},{"key":"B47","first-page":"200","volume":"27","author":"de Carvalho Rocha HA","year":"2014","journal-title":"Ann Gastroenterol"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.11.061"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-15-224"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bts635"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkt214"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp616"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1002\/cpz1.90"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0506580102"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1016\/j.cels.2015.12.004"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1080\/00365521.2020.1754455"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1080\/00365520802276127"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2020-322670"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-021-01676-z"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.578386"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.806002"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1111\/apt.16591"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-015-3807-8"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00011.2022"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2020-321530"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-019-0393-7"}],"container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpgi.00063.2022","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,15]],"date-time":"2022-07-15T17:51:37Z","timestamp":1657907497000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpgi.00063.2022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,1]]},"references-count":66,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,8,1]]}},"alternative-id":["10.1152\/ajpgi.00063.2022"],"URL":"https:\/\/doi.org\/10.1152\/ajpgi.00063.2022","relation":{},"ISSN":["0193-1857","1522-1547"],"issn-type":[{"value":"0193-1857","type":"print"},{"value":"1522-1547","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,1]]},"assertion":[{"value":"2022-03-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-18","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}