{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T02:35:46Z","timestamp":1744252546775,"version":"3.37.3"},"reference-count":46,"publisher":"American Physiological Society","issue":"5","funder":[{"name":"Innovation Capability Support Program of Shaanxi","award":["2022PT-37"],"award-info":[{"award-number":["2022PT-37"]}]},{"name":"Basic-Clinical Joint & Innovative Project of the First Affiliated Hospital of Xi'an University","award":["YXJLRH2022025"],"award-info":[{"award-number":["YXJLRH2022025"]}]},{"DOI":"10.13039\/501100001809","name":"MOST | National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070470"],"award-info":[{"award-number":["82070470"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"published-print":{"date-parts":[[2023,11,1]]},"abstract":"<jats:p> In this study, we present the first evidence that liver mediator 1 (MED1) deficiency attenuated carbon tetrachloride-induced hepatic fibrosis in mouse. The underlying mechanism is that MED1 deficiency reduces reactive oxygen species (ROS) production in hepatocytes, thus restricts the activation of TGF-\u03b2\/Smad2\/3 signaling pathway and fibrogenic genes expression in hepatic stellate cells (HSCs). These data suggest that MED1 is an essential regulator for hepatic fibrogenesis, and MED1 may be considered as a potential therapeutic target for liver fibrosis. <\/jats:p>","DOI":"10.1152\/ajpgi.00076.2023","type":"journal-article","created":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T14:00:34Z","timestamp":1693922434000},"page":"G418-G428","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Mediator subunit MED1 deficiency prevents carbon tetrachloride-induced hepatic fibrosis in mice"],"prefix":"10.1152","volume":"325","author":[{"given":"Jie","family":"Gao","sequence":"first","affiliation":[{"name":"Department of Laboratory Animal Science, School of Basic Medical Sciences, Xi\u2019an Jiaotong University, Xi\u2019an, People\u2019s Republic of China"},{"name":"Cardiometabolic Innovation Center, Ministry of Education, Xi'an, People\u2019s Republic of China"},{"name":"School of Biological Science Technology and Engineering, Shaanxi University of Technology, Hanzhong, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miaoye","family":"Bao","sequence":"additional","affiliation":[{"name":"Department of Laboratory Animal Science, School of Basic Medical Sciences, Xi\u2019an Jiaotong University, Xi\u2019an, People\u2019s Republic of China"},{"name":"Cardiometabolic Innovation Center, Ministry of Education, Xi'an, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanming","family":"Xing","sequence":"additional","affiliation":[{"name":"Cardiometabolic Innovation Center, Ministry of Education, Xi'an, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiming","family":"Ding","sequence":"additional","affiliation":[{"name":"Cardiometabolic Innovation Center, Ministry of Education, Xi'an, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tuo","family":"Han","sequence":"additional","affiliation":[{"name":"Cardiometabolic Innovation Center, Ministry of Education, Xi'an, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ergang","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Laboratory Animal Science, School of Basic Medical Sciences, Xi\u2019an Jiaotong University, Xi\u2019an, People\u2019s Republic of China"},{"name":"Cardiometabolic Innovation Center, Ministry of Education, Xi'an, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Laboratory Animal Science, School of Basic Medical Sciences, Xi\u2019an Jiaotong University, Xi\u2019an, People\u2019s Republic of China"},{"name":"Cardiometabolic Innovation Center, Ministry of Education, Xi'an, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaoyun","family":"Yue","sequence":"additional","affiliation":[{"name":"Department of Laboratory Animal Science, School of Basic Medical Sciences, Xi\u2019an Jiaotong University, Xi\u2019an, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Animal Science, School of Basic Medical Sciences, Xi\u2019an Jiaotong University, Xi\u2019an, People\u2019s Republic of China"},{"name":"Cardiometabolic Innovation Center, Ministry of Education, Xi'an, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Biological Science Technology and Engineering, Shaanxi University of Technology, Hanzhong, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7453-0344","authenticated-orcid":false,"given":"Junhui","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, First Affiliated Hospital, Xi\u2019an Jiaotong University, Xi\u2019an, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sihai","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Laboratory Animal Science, School of Basic Medical Sciences, Xi\u2019an Jiaotong University, Xi\u2019an, People\u2019s Republic of China"},{"name":"Cardiometabolic Innovation Center, Ministry of Education, Xi'an, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiansheng","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enqi","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Laboratory Animal Science, School of Basic Medical Sciences, Xi\u2019an Jiaotong University, Xi\u2019an, People\u2019s Republic of China"},{"name":"Cardiometabolic Innovation Center, Ministry of Education, Xi'an, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4129-8662","authenticated-orcid":false,"given":"Liang","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Laboratory Animal Science, School of Basic Medical Sciences, Xi\u2019an Jiaotong University, Xi\u2019an, People\u2019s Republic of China"},{"name":"Cardiometabolic Innovation Center, Ministry of Education, Xi'an, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3951"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1038\/nature21393"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1126\/science.abg3074"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-022-00498-3"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2019.06.014"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.3727\/105221614X13919976902219"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.41.25500"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M107995200"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2011.07.026"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.16.8329"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M701956200"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgp306"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.3727\/105221609788681213"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24155"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2021.1899691"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2019.11.311"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-020-00372-7"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1002\/hep.32285"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-0716-1382-5_23"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2015.08.015"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M402391200"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.117.309672"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2022.03.013"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmgh.2021.12.018"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00358.2018"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2023.03.038"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1007\/112_2018_10"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31743"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-56553-3"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1172\/JCI111621"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2005.02.010"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1080\/01926230701584163"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0506000102"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2021.10.002"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.21037\/atm-20-2948"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1111\/liv.14940"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-20-0118"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms3823"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2017.38"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.3390\/cells8111419"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28382"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-020-00408-y"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.03.051"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a022301"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2017.109"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30626"}],"container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpgi.00076.2023","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T17:46:19Z","timestamp":1695923179000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpgi.00076.2023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,1]]},"references-count":46,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,11,1]]}},"alternative-id":["10.1152\/ajpgi.00076.2023"],"URL":"https:\/\/doi.org\/10.1152\/ajpgi.00076.2023","relation":{},"ISSN":["0193-1857","1522-1547"],"issn-type":[{"type":"print","value":"0193-1857"},{"type":"electronic","value":"1522-1547"}],"subject":[],"published":{"date-parts":[[2023,11,1]]},"assertion":[{"value":"2023-04-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-17","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}