{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T11:38:09Z","timestamp":1771501089806,"version":"3.50.1"},"reference-count":27,"publisher":"American Physiological Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"published-print":{"date-parts":[[2005,8]]},"abstract":"<jats:p>Host defense of the small intestine is mediated, in part, by antimicrobial peptides, including \u03b1-defensins. In the small intestine, Paneth cells, specialized secretory epithelial cells located at the base of the crypt invaginations lining the intestinal wall, produce \u03b1-defensins. The \u03b1-defensins are cysteine-rich cationic peptides with antibiotic activity against a wide range of bacteria and other microbes. Studies of transgenic and knockout mice have supported a pivotal role of Paneth cell \u03b1-defensins in protection from bacterial pathogens. New data suggest that deficient expression of Paneth cell \u03b1-defensins may contribute to the pathophysiology of Crohn's disease, a chronic inflammatory bowel disease.<\/jats:p>","DOI":"10.1152\/ajpgi.00079.2005","type":"journal-article","created":{"date-parts":[[2005,7,14]],"date-time":"2005-07-14T00:06:27Z","timestamp":1121299587000},"page":"G173-G176","source":"Crossref","is-referenced-by-count":26,"title":["Events at the Host-Microbial Interface of the Gastrointestinal Tract V. Paneth cell \u03b1-defensins in intestinal host defense"],"prefix":"10.1152","volume":"289","author":[{"given":"Charles L.","family":"Bevins","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1038\/77783"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M107507200"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1097\/00001574-200411000-00012"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2003.50045"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-200306000-00008"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1038\/ni797"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1999.277.1.H351"},{"key":"R8","doi-asserted-by":"crossref","unstructured":"Jones DEand Bevins CL.Paneth cells of the human small intestine express an antimicrobial peptide gene.J Biol Chem267: 23216\u201323225, 1992.","DOI":"10.1016\/S0021-9258(18)50079-X"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1126\/science.1104911"},{"key":"R10","unstructured":"Lehrer RI, Bevins CL, and Ganz T.Defensins and other antimicrobial peptides. 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