{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T08:02:07Z","timestamp":1790928127605,"version":"4.1.0"},"reference-count":64,"publisher":"American Physiological Society","issue":"2","funder":[{"DOI":"10.13039\/100017618","name":"HHS | NIH | NIDDK | Division of Diabetes, Endocrinology, and Metabolic Diseases","doi-asserted-by":"publisher","award":["DK120824"],"award-info":[{"award-number":["DK120824"]}],"id":[{"id":"10.13039\/100017618","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"HHS | NIH | National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["NS113873"],"award-info":[{"award-number":["NS113873"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"published-print":{"date-parts":[[2024,2,1]]},"abstract":"<jats:p> We used high-throughput GCaMP6f recordings to study 2,275 mechanosensitive colorectal afferents in mice. Our results revealed significant sex differences in the zymosan-induced behavioral visceral hypersensitivity, which were present in male but not female mice. Male mice also showed sensitization of colorectal afferents in the thoracolumbar pathway, whereas female mice did not. These findings highlight sex differences in sensory neural anatomy and function of the colorectum, with implications for sex-specific therapies for treating visceral pain. <\/jats:p>","DOI":"10.1152\/ajpgi.00081.2023","type":"journal-article","created":{"date-parts":[[2023,12,5]],"date-time":"2023-12-05T09:00:34Z","timestamp":1701766834000},"page":"G133-G146","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":11,"title":["Sex differences in zymosan-induced behavioral visceral hypersensitivity and colorectal afferent sensitization"],"prefix":"10.1152","volume":"326","author":[{"given":"Tiantian","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering, University of Connecticut, Storrs, Connecticut, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, University of Connecticut, Storrs, Connecticut, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longtu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, University of Connecticut, Storrs, Connecticut, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zichao","family":"Bian","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, University of Connecticut, Storrs, Connecticut, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoan","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, University of Connecticut, Storrs, Connecticut, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9277-211X","authenticated-orcid":false,"given":"Bin","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, University of Connecticut, Storrs, Connecticut, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2012.02.029"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2005.02463.x"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1999.01009.x"},{"key":"B4","first-page":"37","volume":"5","author":"Chial HJ","year":"2002","journal-title":"J Gend Specif Med"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0b013e328351b2c2"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00729.2005"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1053\/eujp.2000.0167"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2012.11.008"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.14097"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/85.6.907"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00824.2005"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2012.06.019"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00324.2002"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2021.135667"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2008.04.070"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2005.07.011"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1136\/gut.50.4.471"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2018.02.007"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00490.2011"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00257.2012"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.04.028"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/s0304-3959(03)00210-0"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2005.02.009"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2008.04.002"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2021.657361"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.06.048"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1002\/cne.22730"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00363.2020"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2007.392"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1186\/s40738-020-00074-3"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2089"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00406.2010"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00430.2015"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.14440\/jbm.2014.36"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1109\/TCSI.2006.884469"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00487.2009"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2005.089714"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.04.008"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.3791\/52310"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00462.2015"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3791-08.2009"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00154.2004"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00417.2010"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00016.2019"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00717.2014"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceca.2020.102225"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-019-02088-8"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.04.042"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0907697107"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2009.169300"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00036.2004"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1080\/21548331.1988.11703538"},{"key":"B53","first-page":"28","volume":"1","author":"Kendler K","year":"1998","journal-title":"J Gend Specif Med"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.157.8.1243"},{"key":"B55","doi-asserted-by":"crossref","first-page":"12","DOI":"10.4088\/JCP.v58n0102","volume":"58","author":"Kornstein SG","year":"1997","journal-title":"J Clin Psychiatry"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1016\/j.cnur.2009.06.002"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00500.2004"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2012.01.066"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2006.02.015"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1002\/cne.20816"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200007140-00011"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00259.2012"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1994.71.6.2046"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2982.2003.00456.x"}],"container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpgi.00081.2023","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T20:13:43Z","timestamp":1705436023000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpgi.00081.2023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,1]]},"references-count":64,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,2,1]]}},"alternative-id":["10.1152\/ajpgi.00081.2023"],"URL":"https:\/\/doi.org\/10.1152\/ajpgi.00081.2023","relation":{},"ISSN":["0193-1857","1522-1547"],"issn-type":[{"value":"0193-1857","type":"print"},{"value":"1522-1547","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,1]]},"assertion":[{"value":"2023-04-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-22","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}