{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T17:04:27Z","timestamp":1789232667817,"version":"build-2803163510"},"reference-count":30,"publisher":"American Physiological Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"published-print":{"date-parts":[[2002,8,1]]},"abstract":"<jats:p> Colonic motility is modulated by the 5-hydroxytryptamine (5-HT)<jats:sub>3<\/jats:sub>-dependent gastrocolonic response and 5-HT<jats:sub>3<\/jats:sub>-independent peristaltic reflex. We compared descending colon tone responses to antral distension, duodenal lipid perfusion, and colonic distension after double-blind placebo or granisetron in 13 healthy volunteers and nine slow-transit constipated patients. Antral distension (100\u2013300 ml) and duodenal lipids (3 kcal\/min) evoked increases in colon tone in volunteers, which were blunted in constipated patients ( P &lt; 0.05). Granisetron (10 \u03bcg\/kg) reduced responses to antral distension and lipids in volunteers and to lipids in constipated patients ( P &lt; 0.05). The ascending contraction of the peristaltic reflex was blunted in constipated patients ( P &lt; 0.05), whereas descending responses were similar. Granisetron did not modify the peristaltic reflex. Colonic responses to bethanechol were similar in patients and volunteers. In conclusion, antral distension- and duodenal lipid-activated gastrocolonic responses and ascending contractions of the peristaltic reflex are impaired with slow-transit constipation with loss of both 5-HT<jats:sub>3<\/jats:sub>-dependent and -independent function. Thus abnormalities of neural reflex modulation of colonic motor function may play pathophysiological roles in slow-transit constipation. <\/jats:p>","DOI":"10.1152\/ajpgi.00082.2001","type":"journal-article","created":{"date-parts":[[2015,3,3]],"date-time":"2015-03-03T19:55:51Z","timestamp":1425412551000},"page":"G400-G407","source":"Crossref","is-referenced-by-count":45,"title":["Impaired gastrocolonic response and peristaltic reflex  in slow-transit constipation: role of 5-HT<sub>3<\/sub> pathways"],"prefix":"10.1152","volume":"283","author":[{"given":"Einar S.","family":"Bj\u00f6rnsson","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Sahlgrenska University Hospital, S-41345 Gothenburg, Sweden; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William D.","family":"Chey","sequence":"additional","affiliation":[{"name":"University of Michigan, Ann Arbor, Michigan 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