{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T03:33:01Z","timestamp":1793331181655,"version":"4.5.0"},"reference-count":187,"publisher":"American Physiological Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"published-print":{"date-parts":[[2015,1,15]]},"abstract":"<jats:p>Research in the field of ischemia-reperfusion injury continues to be plagued by the inability to translate research findings to clinically useful therapies. This may in part relate to the complexity of disease processes that result in intestinal ischemia but may also result from inappropriate research model selection. Research animal models have been integral to the study of ischemia-reperfusion-induced intestinal injury. However, the clinical conditions that compromise intestinal blood flow in clinical patients ranges widely from primary intestinal disease to processes secondary to distant organ failure and generalized systemic disease. Thus models that closely resemble human pathology in clinical conditions as disparate as volvulus, shock, and necrotizing enterocolitis are likely to give the greatest opportunity to understand mechanisms of ischemia that may ultimately translate to patient care. Furthermore, conditions that result in varying levels of ischemia may be further complicated by the reperfusion of blood to tissues that, in some cases, further exacerbates injury. This review assesses animal models of ischemia-reperfusion injury as well as the knowledge that has been derived from each to aid selection of appropriate research models. In addition, a discussion of the future of intestinal ischemia-reperfusion research is provided to place some context on the areas likely to provide the greatest benefit from continued research of ischemia-reperfusion injury.<\/jats:p>","DOI":"10.1152\/ajpgi.00112.2013","type":"journal-article","created":{"date-parts":[[2014,11,21]],"date-time":"2014-11-21T07:02:50Z","timestamp":1416553370000},"page":"G63-G75","source":"Crossref","is-referenced-by-count":227,"title":["Animal models of ischemia-reperfusion-induced intestinal injury: progress and promise for translational research"],"prefix":"10.1152","volume":"308","author":[{"given":"Liara M.","family":"Gonzalez","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences, Center for Comparative Medicine and Translational Research, North Carolina State University, Raleigh, North Carolina; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam J.","family":"Moeser","sequence":"additional","affiliation":[{"name":"Department of Population Health and Pathobiology, Center for Comparative Medicine and Translational Research, North Carolina State University, Raleigh, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony T.","family":"Blikslager","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Center for Comparative Medicine and Translational Research, North Carolina State University, Raleigh, North Carolina; and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2007.02.003"},{"key":"B2","first-page":"811","volume":"5","author":"Aharinejad S","year":"1991","journal-title":"Scanning Microsc"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199802000-00012"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(00)70182-X"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-005-1273-1"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2005.09.009"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2014.01.015"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1038\/nature06196"},{"key":"B9","first-page":"56","volume":"37","author":"Bellamy JE","year":"1973","journal-title":"Can J Comp Med"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1093\/bfgp\/elq004"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64192-2"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1590\/S0102-86502012001100006"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00040.2012"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1080\/10715760412331273430"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(95)90440-9"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.11.049"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.cveq.2003.08.004"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.2001.281.2.G375"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6060(99)70264-3"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.1999.276.1.G28"},{"key":"B21","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.2460\/javma.1997.211.11.1387","volume":"211","author":"Blikslager AT","year":"1997","journal-title":"J Am Vet Med Assoc"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6060(97)90107-0"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119723"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.2000.278.2.G207"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2010.09.012"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1006\/jsre.1995.1170"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1590\/S0102-86502011000300006"},{"key":"B28","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1097\/RLI.0b013e3182809143","volume":"48","author":"Bruhn RS","year":"2013","journal-title":"Invest Radiol"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.3700464"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0044772"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2012.07.058"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(200002)190:3<255::AID-PATH526>3.0.CO;2-6"},{"key":"B33","first-page":"9","volume-title":"Physiology of the Intestinal Circulation","author":"Casley-Smith JR","year":"1984"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1016\/0026-2862(71)90006-9"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(98)90614-5"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2011.167"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2013.03.018"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v9.i4.795"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1970.01340280030009"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-030212-183744"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2013.08.006"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00218.2007"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.90446.2008"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.22.10.1276"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1016\/0300-9629(87)90542-1"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0003428"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2009.09.046"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1997.273.4.C1130"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M405323200"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2006.09.055"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1007\/s11894-010-0127-y"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1016\/0022-4804(90)90255-Z"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000000631"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M405095200"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.124.4.619"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-013-1674-y"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.38.23729"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1067\/msy.2002.125320"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-012-9591-x"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2012.07.055"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2012.11.021"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2012.07.059"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0066465"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1002\/stem.1391"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.1989.257.5.G683"},{"key":"B66","first-page":"47","author":"Granger DN","year":"1986","journal-title":"Acta Physiol Scand"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(86)90078-8"},{"key":"B68","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/0016-5085(81)90648-X","volume":"81","author":"Granger DN","year":"1981","journal-title":"Gastroenterology"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1097\/ANC.0b013e31821baaf4"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.1986.251.4.G567"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.1982.242.5.G448"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.10.040"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.4161\/gmic.23866"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2011-301956"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2010.091069"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3306.2011.00402.x"},{"key":"B77","first-page":"211","volume":"116","author":"Grum CM","year":"1990","journal-title":"J Lab Clin Med"},{"key":"B78","first-page":"147","volume":"151","author":"Haglind E","year":"1985","journal-title":"Acta Chir Scand"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.10.6373"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.1995.268.1.G116"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1097\/MOH.0000000000000001"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.1987.253.1.G49"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1987.253.3.H699"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.11.017"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.07.106"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2010.177"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1136\/gut.42.4.530"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1023\/A:1021049004188"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.3945\/jn.111.150995"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.3109\/10739689409148272"},{"key":"B91","first-page":"135","volume":"42","author":"Kanwar S","year":"1994","journal-title":"Circ Shock"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1002\/bdd.2510160502"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.12.015"},{"key":"B94","first-page":"1970","volume":"50","author":"Kawata K","year":"2003","journal-title":"Hepatogastroenterology"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1097\/00004728-200403000-00006"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.1097\/00004728-199603000-00016"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.1993.264.1.G143"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(92)90010-V"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1007\/BF01296817"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.1990.259.2.G300"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.1992.262.5.G878"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.1023\/A:1005674426690"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2013.11.012"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00201.2012"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.1161\/circ.90.3.8087970"},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.1097\/MOT.0b013e32835ef1eb"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.1992.263.3.G301"},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.1016\/j.trre.2008.08.003"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12448"},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00121.2002"},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2013.01.064"},{"key":"B112","doi-asserted-by":"publisher","DOI":"10.1023\/B:DDAS.0000042232.98927.91"},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2008.06.019"},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2005.07.064"},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0007045"},{"key":"B116","doi-asserted-by":"publisher","DOI":"10.1016\/0022-4804(90)90257-3"},{"key":"B117","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.06.004"},{"key":"B118","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00183.2006"},{"key":"B119","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00380.2005"},{"key":"B120","first-page":"1434","volume":"55","author":"Moore RM","year":"1994","journal-title":"Am J Vet Res"},{"key":"B121","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.1995.tb03285.x"},{"key":"B122","doi-asserted-by":"publisher","DOI":"10.1023\/A:1027318203971"},{"key":"B123","first-page":"69","volume":"53","author":"Myer MS","year":"1982","journal-title":"J S Afr Vet Assoc"},{"key":"B124","first-page":"131","volume":"49","author":"Myer MS","year":"1982","journal-title":"Onderstepoort J Vet Res"},{"key":"B125","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2008.01.003"},{"key":"B126","doi-asserted-by":"publisher","DOI":"10.1080\/003655200750023769"},{"key":"B127","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1005408"},{"key":"B128","doi-asserted-by":"publisher","DOI":"10.1159\/000129253"},{"key":"B129","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.1989.257.3.G409"},{"key":"B130","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(94)90695-5"},{"key":"B131","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117541"},{"key":"B132","doi-asserted-by":"publisher","DOI":"10.1124\/pr.58.1.6"},{"key":"B133","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(03)00569-4"},{"key":"B134","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199201000-00026"},{"key":"B135","first-page":"574","volume":"107","author":"Park PO","year":"1990","journal-title":"Surgery"},{"key":"B136","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/0016-5085(82)90115-9","volume":"82","author":"Parks DA","year":"1982","journal-title":"Gastroenterology"},{"key":"B137","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.1986.250.6.G749"},{"key":"B138","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.1983.245.2.G285"},{"key":"B139","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2014.08.004"},{"key":"B140","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.1999.277.3.G495"},{"key":"B141","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1999.277.2.C183"},{"key":"B142","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(87)91080-8"},{"key":"B143","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1287871"},{"key":"B144","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2168.2002.02279.x"},{"key":"B145","doi-asserted-by":"publisher","DOI":"10.1002\/wsbm.1176"},{"key":"B146","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.09.033"},{"key":"B147","doi-asserted-by":"publisher","DOI":"10.1136\/gut.22.6.512"},{"key":"B148","doi-asserted-by":"publisher","DOI":"10.1016\/j.gassur.2005.07.034"},{"key":"B149","doi-asserted-by":"publisher","DOI":"10.1016\/j.dci.2008.06.016"},{"key":"B150","doi-asserted-by":"publisher","DOI":"10.1093\/icvts\/ivt552"},{"key":"B151","doi-asserted-by":"publisher","DOI":"10.1093\/icvts\/ivu139"},{"key":"B152","doi-asserted-by":"publisher","DOI":"10.1038\/nature09637"},{"key":"B153","doi-asserted-by":"publisher","DOI":"10.1136\/gut.32.8.905"},{"key":"B154","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1055\/s-0032-1311039","volume":"184","author":"Schwartz CA","year":"2012","journal-title":"Rofo"},{"key":"B155","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-013-3404-7"},{"key":"B156","doi-asserted-by":"publisher","DOI":"10.1172\/JCI10913"},{"key":"B157","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-012-2391-1"},{"key":"B158","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v19.i23.3583"},{"key":"B159","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ph.44.030182.000305"},{"key":"B160","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00076.2003"},{"key":"B161","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2013.01.028"},{"key":"B162","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63839-4"},{"key":"B163","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-011-1623-0"},{"key":"B164","doi-asserted-by":"publisher","DOI":"10.1002\/jlb.50.5.488"},{"key":"B165","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1989.257.5.H1740"},{"key":"B166","doi-asserted-by":"publisher","DOI":"10.1007\/s002689900065"},{"key":"B167","doi-asserted-by":"publisher","DOI":"10.1126\/science.1213214"},{"key":"B168","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2012.01.023"},{"key":"B169","doi-asserted-by":"publisher","DOI":"10.1007\/s13318-013-0151-z"},{"key":"B170","doi-asserted-by":"publisher","DOI":"10.1016\/j.acra.2010.04.014"},{"key":"B171","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-007-0277-z"},{"key":"B172","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-001-1220-2"},{"key":"B173","doi-asserted-by":"publisher","DOI":"10.1006\/jsre.1994.1035"},{"key":"B174","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.37072"},{"key":"B175","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.05.035"},{"key":"B176","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.01.031"},{"key":"B177","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00519.2011"},{"key":"B178","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.20873"},{"key":"B179","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0042027"},{"key":"B180","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1994.tb09683.x"},{"key":"B181","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2012.1044"},{"key":"B182","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2012.07.025"},{"key":"B183","doi-asserted-by":"publisher","DOI":"10.1007\/s00595-004-2924-0"},{"key":"B184","doi-asserted-by":"publisher","DOI":"10.1007\/BF01852385"},{"key":"B185","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00159.2002"},{"key":"B186","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1990.259.2.H390"},{"key":"B187","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.1990.258.2.G185"}],"container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajpgi.00112.2013","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T06:22:42Z","timestamp":1717568562000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajpgi.00112.2013"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,15]]},"references-count":187,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,1,15]]}},"alternative-id":["10.1152\/ajpgi.00112.2013"],"URL":"https:\/\/doi.org\/10.1152\/ajpgi.00112.2013","relation":{},"ISSN":["0193-1857","1522-1547"],"issn-type":[{"value":"0193-1857","type":"print"},{"value":"1522-1547","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1,15]]}}}