{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T16:59:39Z","timestamp":1781715579839,"version":"3.54.5"},"reference-count":51,"publisher":"American Physiological Society","issue":"2","funder":[{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["092993"],"award-info":[{"award-number":["092993"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Lauren Page Trust"},{"DOI":"10.13039\/501100000380","name":"Guy's and St Thomas' Charity","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000380","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"published-print":{"date-parts":[[2020,8,1]]},"abstract":"<jats:p> We used a mouse model of gestational hypercholanemia to investigate the use of obeticholic acid (OCA), a potent FXR agonist, as a treatment for the hypercholanemia of intrahepatic cholestasis of pregnancy (ICP). The results demonstrate that OCA can improve the fetal bile acid profile. This is relevant not only to women with ICP but also for women who become pregnant while receiving OCA treatment for other conditions such as primary biliary cholangitis and nonalcoholic steatohepatitis. <\/jats:p>","DOI":"10.1152\/ajpgi.00126.2020","type":"journal-article","created":{"date-parts":[[2020,6,29]],"date-time":"2020-06-29T14:37:16Z","timestamp":1593441436000},"page":"G197-G211","source":"Crossref","is-referenced-by-count":12,"title":["Obeticholic acid improves fetal bile acid profile in a mouse model of gestational hypercholanemia"],"prefix":"10.1152","volume":"319","author":[{"given":"Vanessa","family":"Pataia","sequence":"first","affiliation":[{"name":"Department of Women and Children\u2019s Health, King\u2019s College London, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saraid","family":"McIlvride","sequence":"additional","affiliation":[{"name":"Department of Women and Children\u2019s Health, King\u2019s College London, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgia","family":"Papacleovoulou","sequence":"additional","affiliation":[{"name":"Department of Women and Children\u2019s Health, King\u2019s College London, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Ovadia","sequence":"additional","affiliation":[{"name":"Department of Women and Children\u2019s Health, King\u2019s College London, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie A. K.","family":"McDonald","sequence":"additional","affiliation":[{"name":"MRC Centre for Molecular Bacteriology and Infection, Imperial College London, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annika","family":"Wahlstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Molecular and Clinical Medicine\/Wallenberg Laboratory, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eug\u00e8ne","family":"Jansen","sequence":"additional","affiliation":[{"name":"Centre for Health Protection, National Institute for Public Health and the Environment, Bilthoven, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciano","family":"Adorini","sequence":"additional","affiliation":[{"name":"Intercept Pharmaceuticals, San Diego, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Shapiro","sequence":"additional","affiliation":[{"name":"Intercept Pharmaceuticals, San Diego, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian R.","family":"Marchesi","sequence":"additional","affiliation":[{"name":"Department of Metabolism, Digestion and Reproduction, Imperial College London, London, United Kingdom"},{"name":"School of Biosciences, Cardiff University, Cardiff, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanns-Ulrich","family":"Marschall","sequence":"additional","affiliation":[{"name":"Department of Molecular and Clinical Medicine\/Wallenberg Laboratory, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Williamson","sequence":"additional","affiliation":[{"name":"Department of Women and Children\u2019s Health, King\u2019s College London, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28265"},{"key":"B2","first-page":"5","volume":"3","author":"Ali AH","year":"2015","journal-title":"Ann Transl Med"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2007.03462.x"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24537"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkn358"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2014.07.026"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)31270-X"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.e3799"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/7419249"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1177\/1753495X19868873"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000189096.94874.9c"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinre.2015.12.008"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.25542"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.104.079665"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dki321"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.15.2049"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2015.03.020"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26617"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0083828"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20336"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2014.12.005"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000004949"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.63.5.2016-2021.1997"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M306422200"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2013.12.037"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.2337\/dc14-2143"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.07.014"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2017.05.003"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00407.2018"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23849"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00336.2009"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2016.08.021"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.05.042"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymeth.2018.04.028"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2005.06.001"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61933-4"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00449.2016"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30661"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)31877-4"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1172\/JCI68927"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1021\/jm025529g"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12681"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-2-26"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2015.07.009"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.12.010"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.00759-10"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M305258200"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.12174"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28712"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1002\/prp2.329"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0506982103"}],"container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpgi.00126.2020","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,29]],"date-time":"2020-07-29T13:08:14Z","timestamp":1596028094000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpgi.00126.2020"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,1]]},"references-count":51,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,8,1]]}},"alternative-id":["10.1152\/ajpgi.00126.2020"],"URL":"https:\/\/doi.org\/10.1152\/ajpgi.00126.2020","relation":{},"ISSN":["0193-1857","1522-1547"],"issn-type":[{"value":"0193-1857","type":"print"},{"value":"1522-1547","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,1]]}}}