{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T00:04:58Z","timestamp":1773965098259,"version":"3.50.1"},"reference-count":62,"publisher":"American Physiological Society","issue":"6","funder":[{"DOI":"10.13039\/501100000646","name":"Japan Society for the Promotion of Science London","doi-asserted-by":"crossref","award":["JP17K15561"],"award-info":[{"award-number":["JP17K15561"]}],"id":[{"id":"10.13039\/501100000646","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000646","name":"Japan Society for the Promotion of Science London","doi-asserted-by":"publisher","award":["20K16226"],"award-info":[{"award-number":["20K16226"]}],"id":[{"id":"10.13039\/501100000646","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000646","name":"Japan Society for the Promotion of Science London","doi-asserted-by":"publisher","award":["21H02626"],"award-info":[{"award-number":["21H02626"]}],"id":[{"id":"10.13039\/501100000646","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"published-print":{"date-parts":[[2024,12,1]]},"abstract":"<jats:p> AHCC, a standardized extract of cultured Lentinula edodes mycelia, suppresses liver fibrosis progression by induction of cytoglobin via the Toll-like receptor 2 (TLR2)-stress-activated protein kinase\/Jun NH<jats:sub>2<\/jats:sub>-terminal kinase (SAPK\/JNK) pathway and the inhibition of collagen production via the TLR4-NF\u03ba\u03b2 pathway in hepatic stellate cells. Daily oral administration of AHCC from the stage of MASLD may have the potential to prevent disease progression to MASH with fibrosis. <\/jats:p>","DOI":"10.1152\/ajpgi.00134.2024","type":"journal-article","created":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T18:11:04Z","timestamp":1727201464000},"page":"G741-G753","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["AHCC inhibited hepatic stellate cells activation by regulation of cytoglobin induction via TLR2-SAPK\/JNK pathway and collagen production via TLR4-NF-\u03ba\u03b2 pathway"],"prefix":"10.1152","volume":"327","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1040-399X","authenticated-orcid":false,"given":"Hayato","family":"Urushima","sequence":"first","affiliation":[{"name":"Department of Anatomy and Regenerative Biology, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan"},{"name":"Laboratory Animal Facility, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsutomu","family":"Matsubara","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Regenerative Biology, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gu","family":"Qiongya","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Regenerative Biology, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsuko","family":"Daikoku","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Regenerative Biology, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Misako","family":"Takayama","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Regenerative Biology, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiho","family":"Kadono","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Regenerative Biology, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hikaru","family":"Nakai","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Regenerative Biology, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukinobu","family":"Ikeya","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Daiichi University of Pharmacy, Fukuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3979-6213","authenticated-orcid":false,"given":"Hideto","family":"Yuasa","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Regenerative Biology, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2401-969X","authenticated-orcid":false,"given":"Kazuo","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Regenerative Biology, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001320404"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199306243282508"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1002\/cphy.c120035"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.03.003"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.04.061"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2003.50132"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2010.02.022"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23623"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-023-02060-0"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/3758576"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1080\/01635580801993280"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.881902"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.nutres.2012.11.001"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/s0168-8278(02)00091-0"},{"key":"B15","first-page":"33","volume":"24","author":"Cowawintaweewat S","year":"2006","journal-title":"Asian Pac J Allergy Immunol"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M102630200"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3000411"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1177\/0148607107031005373"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2011.05.006"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2014.12.017"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-36215-4"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2021.0279"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.17219\/acem\/43272"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.4137\/JCD.S39824"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M117.793794"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-015-0832-2"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.1.417"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2266"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1863"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0912473"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmgh.2019.09.002"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1097\/HC9.0000000000000107"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2011.78"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2452"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2012.06.005"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.2200855"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1042\/BST20230081"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M407126200"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.2183\/pjab.92.77"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1186\/s40659-019-0229-4"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0091559"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118055"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1038\/srep24990"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.03.051"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2010.482056"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-014-1304-4"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1089\/104454999314890"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2013.03.033"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1159\/000333833"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2003.06.038"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.3177\/jnsv.60.348"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1177\/15347354211073066"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-08-0565"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6605121"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6602972"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.3177\/jnsv.64.8"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2009.07.006"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M511417200"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2021.118443"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.3390\/molecules21060779"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1016\/j.niox.2014.05.007"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2021.119941"}],"container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpgi.00134.2024","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T14:09:25Z","timestamp":1734358165000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpgi.00134.2024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,1]]},"references-count":62,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,12,1]]}},"alternative-id":["10.1152\/ajpgi.00134.2024"],"URL":"https:\/\/doi.org\/10.1152\/ajpgi.00134.2024","relation":{},"ISSN":["0193-1857","1522-1547"],"issn-type":[{"value":"0193-1857","type":"print"},{"value":"1522-1547","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,1]]},"assertion":[{"value":"2024-05-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-10","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}