{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:50:55Z","timestamp":1787165455687,"version":"build-2736575974"},"reference-count":32,"publisher":"American Physiological Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"published-print":{"date-parts":[[2009,12]]},"abstract":"<jats:p>Relationships of regional colonic motility to transit in health, constipation, and constipation-predominant irritable bowel syndrome (C-IBS) are poorly characterized. This study aimed to 1) characterize regional differences in colon pressure, 2) relate motor differences in constipation to colon transit, and 3) quantify the role of IBS in altered contractility with constipation. Colon pH and pressure were measured by wireless capsules in 53 healthy and 36 constipated subjects. Numbers of contractions &gt;25 mmHg and areas under curves (AUC) were calculated for colon transit quartiles by time. Constipation was classified as normal transit (&lt;59 h), moderate slow transit (STC) (59\u2013100 h), and severe STC (&gt;100 h). Twelve out of 36 constipated subjects had C-IBS; 24 had functional constipation. Numbers of contractions and AUCs increased from the first to the fourth quartile in health ( P &lt; 0.0001). Mean numbers of contractions in constipated subjects were similar to controls. Mean AUCs with normal transit ( P = 0.01) and moderate STC ( P = 0.004) but not severe STC ( P = NS) were higher than healthy subjects. IBS was associated with greater mean numbers of contractions ( P = 0.05) and AUCs ( P = 0.0006) vs. controls independent of transit. Numbers of contractions increased from the first to fourth quartiles in moderate STC, C-IBS, and functional constipation; AUCs increased from the first to fourth quartiles in all groups (all P &lt; 0.05). In conclusion, colon pressure activity is greater distally than proximally in health. Constipated patients with normal or moderately delayed transit show increased motor activity that is partly explained by IBS. These findings emphasize differential effects on transit and motility in different constipation subtypes.<\/jats:p>","DOI":"10.1152\/ajpgi.00136.2009","type":"journal-article","created":{"date-parts":[[2009,10,1]],"date-time":"2009-10-01T21:59:37Z","timestamp":1254434377000},"page":"G1107-G1114","source":"Crossref","is-referenced-by-count":67,"title":["Heightened colon motor activity measured by a wireless capsule in patients with constipation: relation to colon transit and IBS"],"prefix":"10.1152","volume":"297","author":[{"given":"William L.","family":"Hasler","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, University of Michigan Health System, Ann Arbor, Michigan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J.","family":"Saad","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, University of Michigan Health System, Ann Arbor, Michigan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satish S.","family":"Rao","sequence":"additional","affiliation":[{"name":"University of Iowa Carver College of Medicine, Iowa City, Iowa;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory E.","family":"Wilding","sequence":"additional","affiliation":[{"name":"State University of New York at Buffalo, Buffalo;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry P.","family":"Parkman","sequence":"additional","affiliation":[{"name":"Temple University Medical Center, Philadelphia, Pennsylvania;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth L.","family":"Koch","sequence":"additional","affiliation":[{"name":"Wake Forest Baptist Medical Center, Winston-Salem, North Carolina;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard W.","family":"McCallum","sequence":"additional","affiliation":[{"name":"University of Kansas Medical Center, Kansas City, Kansas;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Braden","family":"Kuo","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital, Boston, Massachusetts;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Sarosiek","sequence":"additional","affiliation":[{"name":"University of Kansas Medical Center, Kansas City, Kansas;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael D.","family":"Sitrin","sequence":"additional","affiliation":[{"name":"Buffalo Veterans Administration Hospital, Buffalo; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John R.","family":"Semler","sequence":"additional","affiliation":[{"name":"SmartPill Corporation, Buffalo, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William D.","family":"Chey","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, University of Michigan Health System, Ann Arbor, Michigan;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02088064"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1159\/000075554"},{"key":"B3","first-page":"504","volume":"87","author":"Bassotti G","year":"1992","journal-title":"Am J Gastroenterol"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-200406000-00016"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(90)90289-D"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00082.2001"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1007\/s10151-006-0295-9"},{"key":"B8","unstructured":"Brown H , Prescott R. 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