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The majority of studies investigating H. pylori pathogenesis have focused on factors that promote disease development in infected individuals. However, an estimated 85% of those infected with H. pylori remain completely asymptomatic, despite the presence of pathogenic bacteria that drive a chronic gastritis that lasts many decades. This indicates the presence of highly effective regulatory processes in the host that, in most cases, keeps a check on inflammation and protect against disease. In this minireview we discuss such known host factors and how they prevent the development of H. pylori-associated pathologies. <\/jats:p>","DOI":"10.1152\/ajpgi.00146.2016","type":"journal-article","created":{"date-parts":[[2016,7,28]],"date-time":"2016-07-28T23:25:01Z","timestamp":1469748301000},"page":"G514-G520","source":"Crossref","is-referenced-by-count":12,"title":["How host regulation of <i>Helicobacter pylori<\/i>-induced gastritis protects against peptic ulcer disease and gastric cancer"],"prefix":"10.1152","volume":"311","author":[{"given":"Poshmaal","family":"Dhar","sequence":"first","affiliation":[{"name":"Murdoch Childrens Research Institute, Royal Children's Hospital, Parkville, Victoria, Australia;"},{"name":"Centre for Animal Biotechnology, School of Veterinary and Agricultural Science, University of Melbourne, Parkville, Victoria, Australia; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Garrett 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