{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T15:05:44Z","timestamp":1788879944316,"version":"build-2803163510"},"reference-count":60,"publisher":"American Physiological Society","issue":"4","funder":[{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","award":["NNF14CC0001"],"award-info":[{"award-number":["NNF14CC0001"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008392","name":"Sundhed og Sygdom, Det Frie Forskningsr\u00e5d","doi-asserted-by":"publisher","award":["1052-00003B"],"award-info":[{"award-number":["1052-00003B"]}],"id":[{"id":"10.13039\/100008392","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001648","name":"European Foundation for the Study of Diabetes","doi-asserted-by":"publisher","award":["NNF21SA0072746"],"award-info":[{"award-number":["NNF21SA0072746"]}],"id":[{"id":"10.13039\/501100001648","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","award":["NNF19OC0055001"],"award-info":[{"award-number":["NNF19OC0055001"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"published-print":{"date-parts":[[2024,10,1]]},"abstract":"<jats:p> Individuals with metabolic dysfunction-associated steatotic liver disease (MASLD) present with increased plasma levels of glucagon (hyperglucagonemia), irrespective of body mass index (BMI) and type 2 diabetes. Therefore, MASLD and the resultant hyperglucagonemia may act as a diabetogenic risk factor. Notably, hepatic steatosis was a significant contributor to the hyperglucagonemia in MASLD, potentially unveiling a pathway for the hyperglucagonemia in some patients with type 2 diabetes. <\/jats:p>","DOI":"10.1152\/ajpgi.00147.2024","type":"journal-article","created":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T08:01:27Z","timestamp":1722931287000},"page":"G558-G570","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Hepatic steatosis and not type 2 diabetes, body mass index, or hepatic fibrosis associates with hyperglucagonemia in individuals with steatotic liver disease"],"prefix":"10.1152","volume":"327","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4000-5669","authenticated-orcid":false,"given":"Sasha A. S.","family":"Kjeldsen","sequence":"first","affiliation":[{"name":"Department of Clinical Biochemistry, Copenhagen University Hospital - Bispebjerg, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikkel P.","family":"Werge","sequence":"additional","affiliation":[{"name":"Gastro Unit, Copenhagen University Hospital, Amager and Hvidovre, Hvidovre, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2308-2235","authenticated-orcid":false,"given":"Josephine","family":"Grandt","sequence":"additional","affiliation":[{"name":"Gastro Unit, Copenhagen University Hospital, Amager and Hvidovre, Hvidovre, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3861-8469","authenticated-orcid":false,"given":"Michael M.","family":"Richter","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, Copenhagen University Hospital - Bispebjerg, Copenhagen, Denmark"},{"name":"Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mira","family":"Thing","sequence":"additional","affiliation":[{"name":"Gastro Unit, Copenhagen University Hospital, Amager and Hvidovre, Hvidovre, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liv E.","family":"Hetland","sequence":"additional","affiliation":[{"name":"Gastro Unit, Copenhagen University Hospital, Amager and Hvidovre, Hvidovre, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elias B.","family":"Rashu","sequence":"additional","affiliation":[{"name":"Gastro Unit, Copenhagen University Hospital, Amager and Hvidovre, Hvidovre, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5982-8684","authenticated-orcid":false,"given":"Anne-Sofie H.","family":"Jensen","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, Copenhagen University Hospital - Bispebjerg, Copenhagen, Denmark"},{"name":"Gastro Unit, Copenhagen University Hospital, Amager and Hvidovre, Hvidovre, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2144-1385","authenticated-orcid":false,"given":"Marie","family":"Winther-S\u00f8rensen","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, Copenhagen University Hospital - Bispebjerg, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesper Sloth","family":"Kellemann","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, Copenhagen University Hospital - Bispebjerg, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens J.","family":"Holst","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark"},{"name":"Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders E.","family":"Junker","sequence":"additional","affiliation":[{"name":"Gastro Unit, Copenhagen University Hospital, Amager and Hvidovre, Hvidovre, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reza R.","family":"Serizawa","sequence":"additional","affiliation":[{"name":"Department of Pathology, Copenhagen University Hospital, Amager and Hvidovre, Hvidovre, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mogens","family":"Vyberg","sequence":"additional","affiliation":[{"name":"Department of Pathology, Copenhagen University Hospital, Amager and Hvidovre, Hvidovre, Denmark"},{"name":"Department of Clinical Medicine, Center for RNA Medicine, Aalborg University, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lise Lotte","family":"Gluud","sequence":"additional","affiliation":[{"name":"Gastro Unit, Copenhagen University Hospital, Amager and Hvidovre, Hvidovre, Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4230-5753","authenticated-orcid":false,"given":"Nicolai J.","family":"Wewer Albrechtsen","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, Copenhagen University Hospital - Bispebjerg, Copenhagen, Denmark"},{"name":"Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-024-06160-1"},{"key":"B2","doi-asserted-by":"publisher","unstructured":"Kazda CM, Ding Y, Kelly RP, Garhyan P, Shi C, Lim CN, Fu H, Watson DE, Lewin AJ, Landschulz WH, Deeg MA, Moller DE, Hardy TA. Evaluation of efficacy and safetyof the glucagon receptor antagonist LY2409021 in patients with Type 2 diabetes: 12- andv24-week phase 2 studies. Diabetes Care 39:1241-1249, 2016. doi: 10.2337\/dc15-1643.","DOI":"10.2337\/dc15-1643"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1990.259.2.E225"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.2337\/dbi22-0004"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-023-05947-y"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-017-4535-5"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1136\/gut.31.8.946"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1172\/JCI111272"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1172\/JCI107046"},{"key":"B10","first-page":"248","volume":"86","author":"Wolfe BM","year":"1979","journal-title":"Surgery"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2017.05.011"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.2337\/db16-0994"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2015.06.034"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00459.2019"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2020.101080"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00216.2017"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1002\/hep4.1562"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.aohep.2023.101133"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20701"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.8b02100"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jproteome.9b00640"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-020-05334-x"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.2337\/dbi19-0021"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.129954"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.127994"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.2337\/db11-1605"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2022.105296"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2303226"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-91-2-213"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(87)90055-2"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-023-00938-0"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/0261-5614(94)90099-x"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-06614-9"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1111\/liv.14205"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1016\/s0026-0495(98)90036-1"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abf1948"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(77)90091-9"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1987.253.2.E208"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-23-0365"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1126\/science.1260419"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-021-00369-9"},{"key":"B42","first-page":"415","volume":"36","author":"Vilstrup H","year":"1989","journal-title":"Dan Med Bull"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.2174\/1573399815666190502113632"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/nqz191"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2009.02.002"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1080\/00365529850171521"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29465"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.15252\/msb.20167422"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.3390\/nu12051450"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2020.01.013"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1042\/bj1940029"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1721403115"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2019.06.021"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.7570\/jomes22021"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1210\/jendso\/bvad122"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1186\/s12866-022-02704-w"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.903316"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000002718"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000000876"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2018.06.039"}],"container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpgi.00147.2024","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T19:48:13Z","timestamp":1726084093000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpgi.00147.2024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,1]]},"references-count":60,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,10,1]]}},"alternative-id":["10.1152\/ajpgi.00147.2024"],"URL":"https:\/\/doi.org\/10.1152\/ajpgi.00147.2024","relation":{},"ISSN":["0193-1857","1522-1547"],"issn-type":[{"value":"0193-1857","type":"print"},{"value":"1522-1547","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,1]]},"assertion":[{"value":"2024-05-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-15","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}