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Unlike esophageal epithelial cells, ESM cells do not express H<jats:sup>+<\/jats:sup>-K<jats:sup>+<\/jats:sup>-ATPase, and omeprazole does not inhibit their cytokine-stimulated eotaxin-3 secretion or tension. An IL-4R\u03b1 blocking antibody reduces both eotaxin-3 secretion and tension induced by Th2 cytokines in ESM cells, suggesting that an agent such as dupilumab might be preferred for patients with EoE with esophageal muscle involvement. <\/jats:p>","DOI":"10.1152\/ajpgi.00155.2023","type":"journal-article","created":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T09:00:34Z","timestamp":1699347634000},"page":"G38-G52","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["Th2 cytokine signaling through IL-4R\u03b1 increases eotaxin-3 secretion and tension in human esophageal smooth muscle"],"prefix":"10.1152","volume":"326","author":[{"given":"Melissa R.","family":"Nelson","sequence":"first","affiliation":[{"name":"Department of Medicine, Center for Esophageal Diseases, Baylor University Medical Center and Center for Esophageal Research, Baylor Scott and White Research Institute, Dallas, Texas, United 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