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Small intestinal and colonic MCs are neurogenic, occur at similar frequencies, and propagate orally or aborally. Whether they can be coordinated between the different gut regions is unclear. Motor behavior of whole length mouse intestines, from duodenum to terminal rectum, was recorded by intraluminal multisensor catheter. Small intestinal MCs were recorded in 27\/30 preparations, and colonic MCs were recorded in all preparations ( n = 30) with similar frequencies (0.54\u2009\u00b1\u20090.03 and 0.58\u2009\u00b1\u20090.02 counts\/min, respectively). MCs propagated across the ileo-colonic junction in 10\/30 preparations, forming \u201cfull intestine\u201d MCs. The cholinesterase inhibitor physostigmine increased the probability of a full intestine MC but had no significant effect on frequency, speed, or direction. Nitric oxide synthesis blockade by N<jats:sup>\u03c9<\/jats:sup>-nitro-l-arginine, after physostigmine, increased MC frequency in small intestine only. Hyoscine-resistant MCs were recorded in the colon but not small intestine ( n = 5). All MCs were abolished by hexamethonium ( n = 18) or tetrodotoxin ( n = 2). The enteric neural mechanism required for motor complexes is present along the full length of both the small and large intestine. In some cases, colonic MCs can be initiated in the distal colon and propagate through the ileo-colonic junction, all the way to duodenum. In conclusion, the ileo-colonic junction provides functional neural continuity for propagating motor activity that originates in the small or large intestine.<\/jats:p><jats:p>NEW &amp; NOTEWORTHY Intraluminal manometric recordings revealed motor complexes can propagate antegradely or retrogradely across the ileo-colonic junction, spanning the entire small and large intestines. The fundamental enteric neural mechanism(s) underlying cyclic motor complexes exists throughout the length of the small and large intestine.<\/jats:p>","DOI":"10.1152\/ajpgi.00185.2019","type":"journal-article","created":{"date-parts":[[2019,11,11]],"date-time":"2019-11-11T12:36:18Z","timestamp":1573475778000},"page":"G99-G108","source":"Crossref","is-referenced-by-count":16,"title":["Neural motor complexes propagate continuously along the full length of mouse small intestine and colon"],"prefix":"10.1152","volume":"318","author":[{"given":"Marcello","family":"Costa","sequence":"first","affiliation":[{"name":"College of Medicine and Public Health and Centre for Neuroscience, Flinders University, Adelaide, South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3747-140X","authenticated-orcid":false,"given":"Timothy James","family":"Hibberd","sequence":"additional","affiliation":[{"name":"College of Medicine and Public Health and Centre for Neuroscience, Flinders University, Adelaide, South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren J.","family":"Keightley","sequence":"additional","affiliation":[{"name":"College of Medicine and Public Health and Centre for Neuroscience, Flinders University, Adelaide, South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lukasz","family":"Wiklendt","sequence":"additional","affiliation":[{"name":"College of Medicine and Public Health and Centre for Neuroscience, Flinders University, Adelaide, South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John W.","family":"Arkwright","sequence":"additional","affiliation":[{"name":"Computer Science, Engineering and Mathematics, Flinders University, Adelaide, South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8910-2801","authenticated-orcid":false,"given":"Philip G.","family":"Dinning","sequence":"additional","affiliation":[{"name":"College of Medicine and Public Health and Centre for Neuroscience, Flinders University, Adelaide, South Australia, Australia"},{"name":"Department of Gastroenterology and Surgery, Flinders Medical Centre, Flinders University, Adelaide, South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon J. 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