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The present study demonstrated that bile acid, deoxycholic acid (DCA), directly activates esophageal vagal afferent nodose and jugular nociceptive C-fibers and sensitizes their response to capsaicin. Such effects may contribute to bile acid-induced esophageal nociceptive symptoms that refractory to proton-pump inhibitors (PPIs) therapy. <\/jats:p>","DOI":"10.1152\/ajpgi.00187.2021","type":"journal-article","created":{"date-parts":[[2021,6,23]],"date-time":"2021-06-23T15:55:17Z","timestamp":1624463717000},"page":"G149-G156","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Deoxycholic acid activates and sensitizes vagal nociceptive afferent C-fibers in guinea pig esophagus"],"prefix":"10.1152","volume":"321","author":[{"given":"Xiaoyun","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youtian","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingwei","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bradley J.","family":"Undem","sequence":"additional","affiliation":[{"name":"Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1766-8774","authenticated-orcid":true,"given":"Shaoyong","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-540-79090-7_7"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gtc.2020.04.003"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(95)90156-6"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.90250.2008"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2009.188375"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2011.04709.x"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13919"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2004.079574"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00097.2014"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00156.2014"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1172\/JCI64551"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2014.08.042"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.02.031"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2014.271155"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1136\/gut.44.5.598"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2015.00378"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1523\/ENEURO.0494-19.2020"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00785.2001"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.131712"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00016.2019"}],"container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpgi.00187.2021","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,23]],"date-time":"2021-07-23T14:40:00Z","timestamp":1627051200000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpgi.00187.2021"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,1]]},"references-count":20,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,8,1]]}},"alternative-id":["10.1152\/ajpgi.00187.2021"],"URL":"https:\/\/doi.org\/10.1152\/ajpgi.00187.2021","relation":{},"ISSN":["0193-1857","1522-1547"],"issn-type":[{"value":"0193-1857","type":"print"},{"value":"1522-1547","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,1]]},"assertion":[{"value":"2021-05-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-16","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}