{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T02:30:55Z","timestamp":1771468255429,"version":"3.50.1"},"reference-count":48,"publisher":"American Physiological Society","issue":"6","funder":[{"DOI":"10.13039\/501100002809","name":"Generalitat de Catalunya","doi-asserted-by":"publisher","award":["AGAUR 2017-SGR-517"],"award-info":[{"award-number":["AGAUR 2017-SGR-517"]}],"id":[{"id":"10.13039\/501100002809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"MEC | Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["CIBERehd"],"award-info":[{"award-number":["CIBERehd"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"MEC | Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["IFI17\/00010"],"award-info":[{"award-number":["IFI17\/00010"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","award":["SAF PID2019-105\/48RB-100"],"award-info":[{"award-number":["SAF PID2019-105\/48RB-100"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","award":["SAF2017-87301-R"],"award-info":[{"award-number":["SAF2017-87301-R"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","award":["RTI2018-096759-1-100"],"award-info":[{"award-number":["RTI2018-096759-1-100"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","award":["SEV-2016-0644"],"award-info":[{"award-number":["SEV-2016-0644"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"published-print":{"date-parts":[[2021,12,1]]},"abstract":"<jats:p> We have developed two advanced cirrhosis regression experimental models with persistent relevant fibrosis and portal hypertension and an associated deteriorated metabolism that mimic what happens in patients. LI, despite improving metabolism, did not enhance the regression process in our cirrhotic models. CR did not further reduce PP, hepatic fibrosis, or HSC activation. MEE exhibited a profibrogenic effect in the liver blunting cirrhosis regression. One of the potential explanations of this worsening could be ammonia accumulation. <\/jats:p>","DOI":"10.1152\/ajpgi.00191.2021","type":"journal-article","created":{"date-parts":[[2021,9,29]],"date-time":"2021-09-29T12:07:03Z","timestamp":1632917223000},"page":"G603-G616","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Impact of lifestyle interventions targeting physical exercise and caloric intake on cirrhosis regression in rats"],"prefix":"10.1152","volume":"321","author":[{"given":"Erica","family":"Lafoz","sequence":"first","affiliation":[{"name":"Barcelona Hepatic Hemodynamic Laboratory, Liver Unit, Hospital Cl\u00ednic, Universitat de Barcelona, Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gen\u00eds","family":"Campreci\u00f3s","sequence":"additional","affiliation":[{"name":"Barcelona Hepatic Hemodynamic Laboratory, Liver Unit, Hospital Cl\u00ednic, Universitat de Barcelona, Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), Barcelona, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00e9ctor","family":"Garc\u00eda-Calder\u00f3","sequence":"additional","affiliation":[{"name":"Barcelona Hepatic Hemodynamic Laboratory, Liver Unit, Hospital Cl\u00ednic, Universitat de Barcelona, Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), Barcelona, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aina","family":"Anton","sequence":"additional","affiliation":[{"name":"Barcelona Hepatic Hemodynamic Laboratory, Liver Unit, Hospital Cl\u00ednic, Universitat de Barcelona, Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"Vilaseca","sequence":"additional","affiliation":[{"name":"Barcelona Hepatic Hemodynamic Laboratory, Liver Unit, Hospital Cl\u00ednic, Universitat de Barcelona, Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Ruart","sequence":"additional","affiliation":[{"name":"Barcelona Hepatic Hemodynamic Laboratory, Liver Unit, Hospital Cl\u00ednic, Universitat de Barcelona, Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4238-5319","authenticated-orcid":true,"given":"Eduard","family":"Guasch","sequence":"additional","affiliation":[{"name":"Institut Cl\u00ednic Cardiovascular, Hospital Cl\u00ednic, Universitat de Barcelona, Barcelona, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gl\u00f2ria","family":"Garrabou","sequence":"additional","affiliation":[{"name":"Muscle Research and Mitochondrial Function Laboratory, CELLEX-IDIBAPS, University of Barcelona, Barcelona, Spain"},{"name":"CIBERER-Spanish Biomedical Research Centre in Rare Diseases, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa C.","family":"Delgado","sequence":"additional","affiliation":[{"name":"Liver Disease Laboratory, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda-Luz","family":"Mart\u00ednez-Chantar","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, Madrid, Spain"},{"name":"Liver Disease Laboratory, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rita","family":"Garc\u00eda-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, Madrid, Spain"},{"name":"Servicio de Medicina Interna, Hospital General Universitario Gregorio Mara\u00f1\u00f3n, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jordi","family":"Gracia-Sancho","sequence":"additional","affiliation":[{"name":"Barcelona Hepatic Hemodynamic Laboratory, Liver Unit, Hospital Cl\u00ednic, Universitat de Barcelona, Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), Barcelona, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virginia","family":"Hern\u00e1ndez-Gea","sequence":"additional","affiliation":[{"name":"Barcelona Hepatic Hemodynamic Laboratory, Liver Unit, Hospital Cl\u00ednic, Universitat de Barcelona, Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), Barcelona, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9032-4954","authenticated-orcid":true,"given":"Juan Carlos","family":"Garc\u00eda-Pag\u00e1n","sequence":"additional","affiliation":[{"name":"Barcelona Hepatic Hemodynamic Laboratory, Liver Unit, Hospital Cl\u00ednic, Universitat de Barcelona, Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), Barcelona, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2012.03.007"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2011.09.024"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21260"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1172\/JCI1018"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.03.009"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.5858\/2000-124-1599-ROHC"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29097"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.05.050"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29557"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2016.05.027"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.2337\/dc07-0048"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.54.3.603"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23276"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.04.005"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00389.2011"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28992"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1210\/en.2010-0176"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.01.091"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.2001.280.3.h1301"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0104-9"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-879X2002001100018"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1111\/j.1475-097X.1985.tb00753.x"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30890"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1055\/s-0043-112656"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.3305\/nh.2013.28.6.6659"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-018-2340-2"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00510.2010"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2010.310"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1123\/apaq.15.4.386"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1249\/mss.0b013e31802e851a"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2017.01.045"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1053\/S1542-3565(03)00178-2"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01170.2007"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00029.2014"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1249\/01.mss.0000210203.10200.12"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00763.2016"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1996.v111.pm8898644"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510250606"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.11.019"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1515\/bhk-2016-0005"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2010.02302.x"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0151652"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1016\/j.jceh.2018.07.006"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinre.2017.09.005"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/136.1.250s"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1111\/liv.13997"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-014-3086-6"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1007\/s40279-015-0320-0"}],"container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpgi.00191.2021","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,12]],"date-time":"2021-11-12T12:50:33Z","timestamp":1636721433000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpgi.00191.2021"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,1]]},"references-count":48,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,12,1]]}},"alternative-id":["10.1152\/ajpgi.00191.2021"],"URL":"https:\/\/doi.org\/10.1152\/ajpgi.00191.2021","relation":{},"ISSN":["0193-1857","1522-1547"],"issn-type":[{"value":"0193-1857","type":"print"},{"value":"1522-1547","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,1]]},"assertion":[{"value":"2021-06-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}