{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T05:50:55Z","timestamp":1791352255920,"version":"4.3.1"},"reference-count":35,"publisher":"American Physiological Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"published-print":{"date-parts":[[2016,9,1]]},"abstract":"<jats:p>The technically easier one-anastomosis (mini) gastric bypass (MGB) is associated with similar metabolic improvements and weight loss as the Roux-en-Y gastric bypass (RYGB). However, MGB is controversial and suspected to result in greater malabsorption than RYGB. In this study, we compared macronutrient absorption and intestinal adaptation after MGB or RYGB in rats. Body weight and food intake were monitored and glucose tolerance tests were performed in rats subjected to MGB, RYGB, or sham surgery. Carbohydrate, protein, and lipid absorption was determined by fecal analyses. Intestinal remodeling was evaluated by histology and immunohistochemistry. Peptide and amino acid transporter mRNA levels were measured in the remodeled intestinal mucosa and those of anorexigenic and orexigenic peptides in the hypothalamus. The MGB and RYGB surgeries both resulted in a reduction of body weight and an improvement of glucose tolerance relative to sham rats. Hypothalamic orexigenic neuropeptide gene expression was higher in MGB rats than in RYGB or sham rats. Fecal losses of calories and proteins were greater after MGB than RYGB or sham surgery. Intestinal hyperplasia occurred after MGB and RYGB with increased jejunum diameter, higher villi, and deeper crypts than in sham rats. Peptidase and peptide or amino acid transporter genes were overexpressed in jejunal mucosa from MGB rats but not RYGB rats. In rats, MGB led to greater protein malabsorption and energy loss than RYGB. This malabsorption was not compensated by intestinal overgrowth and increased expression of peptide transporters in the jejunum.<\/jats:p>","DOI":"10.1152\/ajpgi.00197.2016","type":"journal-article","created":{"date-parts":[[2016,7,15]],"date-time":"2016-07-15T03:13:34Z","timestamp":1468552414000},"page":"G492-G500","source":"Crossref","is-referenced-by-count":76,"title":["Malabsorption and intestinal adaptation after one anastomosis gastric bypass compared with Roux-en-Y gastric bypass in rats"],"prefix":"10.1152","volume":"311","author":[{"given":"Jean-Baptiste","family":"Cavin","sequence":"first","affiliation":[{"name":"Inserm UMR 1149, Universit\u00e9 Paris Diderot, Sorbonne Paris Cit\u00e9, DHU Unity AP-HP, Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eglantine","family":"Voitellier","sequence":"additional","affiliation":[{"name":"Inserm UMR 1149, Universit\u00e9 Paris Diderot, Sorbonne Paris Cit\u00e9, DHU Unity AP-HP, Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7oise","family":"Cluzeaud","sequence":"additional","affiliation":[{"name":"Inserm UMR 1149, Universit\u00e9 Paris Diderot, Sorbonne Paris Cit\u00e9, DHU Unity AP-HP, Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Kapel","sequence":"additional","affiliation":[{"name":"AP-HP, H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re-Charles Foix, D\u00e9partement de Coprologie Fonctionnelle, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Pierre","family":"Marmuse","sequence":"additional","affiliation":[{"name":"Inserm UMR 1149, Universit\u00e9 Paris Diderot, Sorbonne Paris Cit\u00e9, DHU Unity AP-HP, Paris, France;"},{"name":"Service de Chirurgie G\u00e9n\u00e9rale et Digestive, AP-HP H\u00f4pital Bichat Claude Bernard, Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Marc","family":"Chevallier","sequence":"additional","affiliation":[{"name":"Service de Chirurgie Digestive, AP-HP H\u00f4pital Europ\u00e9en Georges Pompidou, Paris, et Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, France; 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