{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T11:35:59Z","timestamp":1785411359989,"version":"3.56.0"},"reference-count":60,"publisher":"American Physiological Society","issue":"6","funder":[{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL138198"],"award-info":[{"award-number":["HL138198"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006928","name":"Ohio State University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006928","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"published-print":{"date-parts":[[2025,12,1]]},"abstract":"<jats:p>\n                    This study underscores the pivotal role of hepatic PKC\u03b2 in controlling biliary lipid composition under lithogenic stress. Our findings on the distinct and combined effects of downstream p38\n                    <jats:sup>MAPK<\/jats:sup>\n                    and ERK1\/2 offer key insights into the mechanisms driving lithogenic diet-induced dysregulation of biliary lipid composition. This research reveals that the potential of PKC\u03b2\/p38\n                    <jats:sup>MAPK<\/jats:sup>\n                    \/ERK1\/2 signaling axis offers the possibility for the integration of different inputs to modulate the signaling output balancing in a way most appropriate for context.\n                  <\/jats:p>","DOI":"10.1152\/ajpgi.00208.2025","type":"journal-article","created":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T16:52:16Z","timestamp":1759769536000},"page":"G653-G663","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Hepatic protein kinase C\u03b2 antagonizing p38\n                    <sup>MAPK<\/sup>\n                    to activate ERK1\/2 to dysregulate biliary lipid composition upon lithogenic stress"],"prefix":"10.1152","volume":"329","author":[{"given":"Yaoling","family":"Shu","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00c01js51","id-type":"ROR","asserted-by":"publisher"}],"name":"The Ohio State University Wexner Medical Center","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit","family":"Rai","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00c01js51","id-type":"ROR","asserted-by":"publisher"}],"name":"The Ohio State University Wexner Medical Center","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gina M.","family":"Sizemore","sequence":"additional","affiliation":[{"name":"The Ohio State University Wexner Medical Center","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Ostrowski","sequence":"additional","affiliation":[{"name":"Medical University of South Carolina","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1775-6512","authenticated-orcid":false,"given":"Wei","family":"Huang","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00c01js51","id-type":"ROR","asserted-by":"publisher"}],"name":"The Ohio State University Wexner Medical Center","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8553-480X","authenticated-orcid":false,"given":"Kamal D.","family":"Mehta","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00c01js51","id-type":"ROR","asserted-by":"publisher"}],"name":"The Ohio State University Wexner Medical Center","place":["United States"]},{"name":"Instacare Therapeutics","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.32978"},{"key":"B2","first-page":"S1","volume":"10","author":"Hofmann AF","year":"1998","journal-title":"J Clin Gastroenterol"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69044-2"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1040470"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.72.121801.161712"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M411080200"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R900012-JLR200"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90380-9"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1152\/ajplegacy.1964.206.3.628"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.17.7729"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddw406"},{"key":"B12","first-page":"5257","volume":"55","author":"Wali RK","year":"1995","journal-title":"Cancer Res"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.10.024"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2002-3-3-research0014"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1007\/BF00648425"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.250282"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmgh.2015.05.008"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2020.101133"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.149023"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2023.104917"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/s0168-8278(01)00092-7"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.2741\/a273"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1517\/17425250903032681"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA118.004652"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1210\/me.2008-0092"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1210\/me.2003-0327"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M201185200"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29888"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2020-323345"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.25248"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.2337\/db18-0462"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R069286"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29076"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.15881"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2006.12.008"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2007.00702.x"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840210235"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.3858\/emm.2011.43.10.064"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27088"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1773909"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1002\/hep4.1867"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1016\/s1534-5807(02)00154-5"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.28.19593"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111718200"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.38.23512"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M210015200"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.21.8.2650-2658.2001"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1038\/364249a0"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2005.06.025"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.14.1.6"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.13.7161"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S243317"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1016\/s1097-2765(01)00390-2"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M408862200"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22815"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.997"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114514003717"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199302113280608"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.2174\/092986709787909631"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12051897"}],"container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpgi.00208.2025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T19:28:02Z","timestamp":1764012482000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpgi.00208.2025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,1]]},"references-count":60,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,12,1]]}},"alternative-id":["10.1152\/ajpgi.00208.2025"],"URL":"https:\/\/doi.org\/10.1152\/ajpgi.00208.2025","relation":{},"ISSN":["0193-1857","1522-1547"],"issn-type":[{"value":"0193-1857","type":"print"},{"value":"1522-1547","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,1]]},"assertion":[{"value":"2025-06-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-02","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}