{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T03:52:07Z","timestamp":1791863527720,"version":"4.3.4"},"reference-count":45,"publisher":"American Physiological Society","issue":"4","funder":[{"DOI":"10.13039\/501100003123","name":"Fetal Medicine Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003123","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health and Care Research","doi-asserted-by":"publisher","award":["NIHR200254"],"award-info":[{"award-number":["NIHR200254"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health and Care Research","doi-asserted-by":"publisher","award":["IS-BRC-1215-20006)."],"award-info":[{"award-number":["IS-BRC-1215-20006)."]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["092993\/Z\/10\/Z"],"award-info":[{"award-number":["092993\/Z\/10\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"published-print":{"date-parts":[[2025,4,1]]},"abstract":"<jats:p> Sulfated progesterone species (PMxSs) increase postprandially in women with intrahepatic cholestasis of pregnancy (ICP) but not in women with uncomplicated pregnancy. PMxS can be enterohepatically recycled via active transport from the gut lumen by apical sodium-dependent bile acid transporter (ASBT) and stimulate gut hormone secretion. Active reabsorption of PMxS may play a role in the pruritus suffered by women with ICP. ASBT inhibition is a plausible therapy for ICP-associated pruritus. <\/jats:p>","DOI":"10.1152\/ajpgi.00211.2024","type":"journal-article","created":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T15:31:26Z","timestamp":1738337486000},"page":"G377-G385","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Progesterone sulfates are enterohepatically recycled and stimulate G protein-coupled bile acid receptor 1-mediated gut hormone release"],"prefix":"10.1152","volume":"328","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6861-5779","authenticated-orcid":false,"given":"Alice L.","family":"Mitchell","sequence":"first","affiliation":[{"name":"Imperial College London","place":["United Kingdom"]},{"name":"Guy\u2019s Campus, King\u2019s College London","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iain R.","family":"Tough","sequence":"additional","affiliation":[{"name":"King\u2019s College London","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hei Man","family":"Fan","sequence":"additional","affiliation":[{"name":"Guy\u2019s Campus, King\u2019s College London","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"L\u00f6vgren-Sandblom","sequence":"additional","affiliation":[{"name":"Karolinska Institute","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4859-0324","authenticated-orcid":false,"given":"Caroline","family":"Ovadia","sequence":"additional","affiliation":[{"name":"Guy\u2019s Campus, King\u2019s College London","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny","family":"Chambers","sequence":"additional","affiliation":[{"name":"Imperial College London","place":["United Kingdom"]},{"name":"Imperial College London","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Fonseca Pedro","sequence":"additional","affiliation":[{"name":"King\u2019s College London","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasia","family":"Tsakmaki","sequence":"additional","affiliation":[{"name":"King\u2019s College London","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gavin A.","family":"Bewick","sequence":"additional","affiliation":[{"name":"King\u2019s College London","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanns-Ulrich","family":"Marschall","sequence":"additional","affiliation":[{"name":"University of Gothenburg","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9024-1497","authenticated-orcid":false,"given":"Helen M.","family":"Cox","sequence":"additional","affiliation":[{"name":"King\u2019s College London","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6226-7611","authenticated-orcid":false,"given":"Catherine","family":"Williamson","sequence":"additional","affiliation":[{"name":"Imperial College London","place":["United Kingdom"]},{"name":"Guy\u2019s Campus, King\u2019s College London","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ogrm.2018.06.003"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.16669"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.072140"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26055"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.2337\/db21-0702"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28265"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-022-00687-7"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13943"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1111\/BPH.12158"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2018.03.007"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2012.11.008"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.2337\/DIABETES.51.2007.S434"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-10-0047"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2008.164269"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2012.1222"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2009.09.022"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/0022-4731(73)90039-3"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/J.JHEPR.2022.100561"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1111\/BPH.14054"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-9781(01)00355-2"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/J.CMET.2010.04.014"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1210\/EN.2017-03172"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1111\/CTS.12774"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(97)80181-X"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1530\/acta.0.0690775"},{"key":"B26","first-page":"30","volume":"3","author":"Eriksson H","year":"1972","journal-title":"Steroids Lipids Res"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1002\/HEP.21987"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/0022-4731(80)90196-X"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1111\/J.1476-5381.2011.01401.X"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1111\/J.1476-5381.2011.01724.X"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1021\/MP200103H"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2002.34133"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1210\/ER.2015-1036"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1159\/000371565"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1016\/J.NPEP.2012.08.005"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1210\/JC.2017-02006"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2013.12.037"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.2337\/DC14-2143"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1152\/AJPGI.1998.274.1.G157"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1124\/MOL.106.026450"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1021\/ACS.BIOCHEM.0C00711"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1210\/EN.2018-01034"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20061431"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-0350"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(22)00093-0"}],"container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpgi.00211.2024","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T12:51:27Z","timestamp":1744375887000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpgi.00211.2024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,1]]},"references-count":45,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4,1]]}},"alternative-id":["10.1152\/ajpgi.00211.2024"],"URL":"https:\/\/doi.org\/10.1152\/ajpgi.00211.2024","relation":{},"ISSN":["0193-1857","1522-1547"],"issn-type":[{"value":"0193-1857","type":"print"},{"value":"1522-1547","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,1]]},"assertion":[{"value":"2024-07-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-24","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}