{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T11:09:01Z","timestamp":1785409741431,"version":"3.56.0"},"reference-count":84,"publisher":"American Physiological Society","issue":"4","license":[{"start":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T00:00:00Z","timestamp":1741737600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["R01 DK 111834"],"award-info":[{"award-number":["R01 DK 111834"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["W81XWH-21-1-0516"],"award-info":[{"award-number":["W81XWH-21-1-0516"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["HT9425-23-1-0306"],"award-info":[{"award-number":["HT9425-23-1-0306"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["W81XWH-16-1-0570"],"award-info":[{"award-number":["W81XWH-16-1-0570"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["I01CX002478-01A1"],"award-info":[{"award-number":["I01CX002478-01A1"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["I01BX004944"],"award-info":[{"award-number":["I01BX004944"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008333","name":"University of Alabama at Birmingham","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008333","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"published-print":{"date-parts":[[2025,4,1]]},"abstract":"<jats:p>Hedgehog signaling is activated in human and experimental models of CP. Inhibition of hedgehog signaling using an FDA-approved inhibitor, vismodegib, leads to the resolution of fibrosis and improves CP. This study has immense and immediate translational benefits.<\/jats:p>","DOI":"10.1152\/ajpgi.00212.2024","type":"journal-article","created":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T11:00:49Z","timestamp":1730804449000},"page":"G342-G363","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Inhibition of hedgehog signaling ameliorates severity of chronic pancreatitis in experimental mouse models"],"prefix":"10.1152","volume":"328","author":[{"given":"Srikanth","family":"Iyer","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/008s83205","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Alabama at Birmingham","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Tarique","sequence":"additional","affiliation":[{"name":"University of Missouri","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Preeti","family":"Sahay","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/008s83205","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Alabama at Birmingham","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2257-5120","authenticated-orcid":false,"given":"Sagnik","family":"Giri","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/008s83205","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Alabama at Birmingham","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1719-2451","authenticated-orcid":false,"given":"Ejas P.","family":"Bava","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/008s83205","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Alabama at Birmingham","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JiaShiung","family":"Guan","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/008s83205","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Alabama at Birmingham","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tejeshwar","family":"Jain","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/008s83205","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Alabama at Birmingham","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Utpreksha","family":"Vaish","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/008s83205","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Alabama at Birmingham","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuwen","family":"Jin","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/008s83205","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Alabama at Birmingham","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Moon","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/008s83205","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Alabama at Birmingham","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David K.","family":"Crossman","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9011-7638","authenticated-orcid":false,"given":"Vikas","family":"Dudeja","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/008s83205","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Alabama at Birmingham","place":["United States"]},{"name":"Birmingham Veteran Affairs Medical Center","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-017-4602-2"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-44519-3"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1159\/000499612"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics10020087"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1080\/17474124.2024.2355969"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2018.08.004"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0140-2019"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2016.54"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-020-00365-6"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-018-0220-7"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.3390\/cells7110208"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3598"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2010.10.003"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1038\/nature02009"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.4291\/wjgp.v7.i2.199"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475X.2008.00430.x"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01450"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1007\/s11427-016-0020-y"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2011.12.039"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1172\/JCI35875"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.10.017"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v22.i29.6652"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23010171"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1002\/art.34444"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.7555\/JBR.30.20150107"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-20-3715"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2022.108107"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1780467"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i16.4712"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2019.114853"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1016\/j.parint.2017.04.004"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2011-200883"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.3109\/1061186X.2012.719900"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.06.051"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1113713"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1007\/s40264-018-0777-5"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-13869-0"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdt391"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0023943"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2023.106858"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-209698"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2012.05.011"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1016\/j.pan.2022.05.002"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2089"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2818.2006.01706.x"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2818.1993.tb03313.x"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2012.00344"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.11.010"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.01.041"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.5009\/gnl.2008.2.2.74"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2021.10.027"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2017.12"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-021014-071727"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2011-300266"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2012.10.025"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.3390\/cells10010123"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13143410"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/816460"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00167.2006"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1002\/jgh3.12698"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2016.06.018"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1177\/1753425916668243"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keab788"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2022.110274"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2017.03.006"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01732-w"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.4161\/trla.23934"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1097\/01.mpa.0000168222.05591.a0"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.7150\/jca.38616"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2022.865105"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.3700191"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.3700349"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.00754"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.11.037"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.21247"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-76095-1"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.3892\/or.2018.6202"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000002996"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1038\/383407a0"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1101\/gad.13.16.2072"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1038\/1717"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1016\/s0925-4773(02)00331-3"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.22.13036"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.04.011"}],"container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpgi.00212.2024","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T11:22:24Z","timestamp":1744802544000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpgi.00212.2024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,1]]},"references-count":84,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4,1]]}},"alternative-id":["10.1152\/ajpgi.00212.2024"],"URL":"https:\/\/doi.org\/10.1152\/ajpgi.00212.2024","relation":{},"ISSN":["0193-1857","1522-1547"],"issn-type":[{"value":"0193-1857","type":"print"},{"value":"1522-1547","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,1]]},"assertion":[{"value":"2024-07-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-23","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}