{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:47:07Z","timestamp":1792799227162,"version":"4.5.0"},"reference-count":74,"publisher":"American Physiological Society","issue":"3","funder":[{"name":"USDA | National Institute of Food and Agriculture","award":["2019-67017-29372"],"award-info":[{"award-number":["2019-67017-29372"]}],"id":[{"id":"https:\/\/ror.org\/05qx3fv49","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000062","name":"HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["P30 DK 034987"],"award-info":[{"award-number":["P30 DK 034987"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016958","name":"HHS | NIH | Office of Research Infrastructure Programs, National Institutes of Health","doi-asserted-by":"publisher","award":["K01 OD 028207"],"award-info":[{"award-number":["K01 OD 028207"]}],"id":[{"id":"10.13039\/100016958","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007786","name":"National Center for Child Health and Development","doi-asserted-by":"publisher","award":["R01 HD 095876"],"award-info":[{"award-number":["R01 HD 095876"]}],"id":[{"id":"10.13039\/100007786","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"published-print":{"date-parts":[[2024,3,1]]},"abstract":"<jats:p>This study refines a powerful translational pig model, defining an age-dependent relationship between enteric glia and the intestinal epithelium during intestinal ischemic injury and confirming an important role for enteric glial cell (EGC) activity in driving mucosal barrier restitution. This study suggests that targeting the enteric glial network could lead to novel interventions to improve recovery from intestinal injury in neonatal patients.<\/jats:p>","DOI":"10.1152\/ajpgi.00216.2022","type":"journal-article","created":{"date-parts":[[2023,12,26]],"date-time":"2023-12-26T17:57:46Z","timestamp":1703613466000},"page":"G228-G246","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":12,"title":["Enteric glial cell network function is required for epithelial barrier restitution following intestinal ischemic injury in the early postnatal period"],"prefix":"10.1152","volume":"326","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4450-0536","authenticated-orcid":false,"given":"Amanda L.","family":"Ziegler","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9930-7413","authenticated-orcid":false,"given":"Madison L.","family":"Caldwell","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9589-3280","authenticated-orcid":false,"given":"Sara E.","family":"Craig","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily A.","family":"Hellstrom","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasia E.","family":"Sheridan","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa S.","family":"Touvron","sequence":"additional","affiliation":[{"name":"Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiffany A.","family":"Pridgen","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2746-1224","authenticated-orcid":false,"given":"Scott T.","family":"Magness","sequence":"additional","affiliation":[{"name":"Joint Department of Biomedical Engineering, School of Medicine, University of North Carolina, Chapel Hill, North Carolina, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4965-2096","authenticated-orcid":false,"given":"Jack","family":"Odle","sequence":"additional","affiliation":[{"name":"Department of Animal Science, College of Agriculture and Life Sciences, North Carolina State University, Raleigh, North Carolina, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7408-3521","authenticated-orcid":false,"given":"Laurianne","family":"Van Landeghem","sequence":"additional","affiliation":[{"name":"Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony T.","family":"Blikslager","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00012.2006"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00112.2013"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0003428"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2009.00975.x"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2010.11.009"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3468(92)90293-g"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2009.02.013"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1053\/j.sempedsurg.2013.01.004"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1005408"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jemermed.2011.06.135"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000081429.89277.AF"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1017\/S0954422416000020"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmgh.2016.09.003"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2015.01.004"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-015-2163-4"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.2527\/jas.2013-6359"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1177\/0300985811402846"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/s0039-6060(97)90107-0"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0200674"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00232.2015"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00276.2005"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2014.12.037"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00427.2010"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2008.01963.x"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-10-507"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.01.051"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.09.038"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1038\/srep25203"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0550-8"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks042"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.202012724"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(93)90412-6"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00532.2002"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2023.104448"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.10.010"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.09652"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22041887"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.00009.2018"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-014-8730-9"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1089\/sur.2013.103"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0069042"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2014.09.040"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00507.2016"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.3390\/cells9040838"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.04.007"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2003.012625"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2011.01696.x"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1016\/j.acthis.2019.06.001"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-015-3663-3"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.440909"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0803343106"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201694660"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21030972"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2013.00272"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1172\/JCI33538"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1172\/JCI39104"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.826882"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2021-004302"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjy180"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-04006-z"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.08.067"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-021-00423-7"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1113\/JP273492"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00384.2016"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2010.229237"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-64173-3"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2015.1109767"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1002\/glia.22746"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2021.10.004"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(94)90086-8"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-022-03772-4"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-36878-z"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-017-0854-1"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1126\/science.aam7511"}],"container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpgi.00216.2022","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,12]],"date-time":"2024-02-12T15:18:54Z","timestamp":1707751134000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpgi.00216.2022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,1]]},"references-count":74,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3,1]]}},"alternative-id":["10.1152\/ajpgi.00216.2022"],"URL":"https:\/\/doi.org\/10.1152\/ajpgi.00216.2022","relation":{},"ISSN":["0193-1857","1522-1547"],"issn-type":[{"value":"0193-1857","type":"print"},{"value":"1522-1547","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,1]]},"assertion":[{"value":"2022-09-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-23","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}