{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T21:07:02Z","timestamp":1789420022087,"version":"build-2803163510"},"reference-count":65,"publisher":"American Physiological Society","issue":"4","funder":[{"DOI":"10.13039\/100000062","name":"HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["DK111378"],"award-info":[{"award-number":["DK111378"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"HHS | NIH | National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["AA21171"],"award-info":[{"award-number":["AA21171"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007048","name":"Mayo Foundation for Medical Education and Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007048","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["WE 7859\/1-1"],"award-info":[{"award-number":["WE 7859\/1-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009068","name":"University of Bern","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009068","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007048","name":"Mayo Foundation for Medical Education and Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007048","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"published-print":{"date-parts":[[2026,10,1]]},"abstract":"<jats:p>This study presents a refined murine MetALD model designed to distinguish ethanol-modified features from FFC-driven metabolic steatohepatitis. Chronic ethanol did not uniformly worsen liver injury. Instead, it selectively modified disease trajectory through greater early collagen-positive fibrotic remodeling, altering lipid-droplet architecture, and context-dependent inflammatory chemokine signaling. By 24 wk, FFC and FFC\/ethanol injury programs converged, supporting MetALD as a timing- and pathway-dependent modification of metabolic steatohepatitis.<\/jats:p>","DOI":"10.1152\/ajpgi.00223.2026","type":"journal-article","created":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T09:32:28Z","timestamp":1787391148000},"page":"G399-G413","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Ethanol reshapes FFC-driven steatohepatitis through time-dependent fibrosis and lipid-droplet remodeling"],"prefix":"10.1152","volume":"331","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-7116-8931","authenticated-orcid":false,"given":"Jasmin","family":"Weninger","sequence":"first","affiliation":[{"name":"Mayo Clinic","place":["United States"]},{"name":"Ruhr-University Bochum, Knappschaft Kliniken Universit\u00e4tsklinikum Bochum","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2687-3582","authenticated-orcid":false,"given":"Amani","family":"Lee","sequence":"additional","affiliation":[{"name":"Mayo Clinic","place":["United States"]},{"name":"University of Minnesota Medical School","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2995-3660","authenticated-orcid":false,"given":"George W.","family":"Marek","sequence":"additional","affiliation":[{"name":"Mayo Clinic","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9519-4949","authenticated-orcid":false,"given":"Naomi","family":"Lange","sequence":"additional","affiliation":[{"name":"University of Bern","place":["Switzerland"]},{"name":"University of Bern","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy S.","family":"Mauer","sequence":"additional","affiliation":[{"name":"Mayo Clinic","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gyanendra","family":"Puri","sequence":"additional","affiliation":[{"name":"St. Francis Medical Center","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7620-573X","authenticated-orcid":false,"given":"Vijay H.","family":"Shah","sequence":"additional","affiliation":[{"name":"Mayo Clinic","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0882-4990","authenticated-orcid":false,"given":"Harmeet","family":"Malhi","sequence":"additional","affiliation":[{"name":"Mayo Clinic","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(24)00081-5"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2023.03.017"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-023-00822-y"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.aohep.2023.101133"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-024-06196-3"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2022.08.030"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2015.12.012"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1097\/HC9.0000000000000003"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27921"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0163342"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1038\/s44355-024-00014-8"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biochem-061009-102430"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1055\/s-0039-1685524"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.livres.2019.09.002"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-026-39913-6"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jlr.2021.100049"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmgh.2018.01.003"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00365.2011"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-018-0082-x"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.3390\/cells13110960"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1136\/egastro-2025-100319"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1002\/hep4.1698"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1111\/acer.14700"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/j.alcohol.2020.03.007"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1097\/HC9.0000000000000450"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0249316"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-024-01043-6"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00213.2016"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00145.2011"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31897"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20701"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00222.2016"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.3791\/65206"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1097\/HEP.0000000000000323"},{"key":"B35","unstructured":"U.S. FOOD & DRUG ADMINISTRATION. Estimating the Maximum Safe Starting Dose in Initial Clinical Trials for Therapeutics in Adult Healthy Volunteers (Online). U.S. FOOD & DRUG ADMINISTRATION, 2005. https:\/\/www.fda.gov\/regulatory-information\/search-fda-guidance-documents\/estimating-maximum-safe-starting-dose-initial-clinical-trials-therapeutics-adult-healthy-volunteers [2026 May 28]."},{"key":"B36","unstructured":"OSAC. OSAC 2020-S-0003 Guidelines for Performing Alcohol Calculations in Forensic Toxicology (Online). Organization of Scientific Area Committees (OSAC) for Forensic Science, 2021. https:\/\/www.nist.gov\/system\/files\/documents\/2021\/07\/02\/2020-S-0003_Guidelines%20for%20Performing%20Alcohol%20Calculations%20in%20Forensic%20Toxicology_Open%20Comment%20Version.pdf [2026 Jun 14]."},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2024.06.036"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2024.11.028"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2022.04.014"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.01.043"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00287.2009"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2014.09.033"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.3390\/cells8050503"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31987"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31743"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.3390\/ijms242015460"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2004.11.009"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00453.2020"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1111\/acer.15446"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.07.041"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.202408205"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1097\/HC9.0000000000000446"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-018-0085-z"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/978136"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)40613-3"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00013.2024"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00031.2015"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2020.0100"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2012.00213"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.165369"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29544"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-00671-1"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000001240"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2024.05.013"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-28138-6"}],"container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpgi.00223.2026","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T20:53:31Z","timestamp":1789419211000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpgi.00223.2026"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,1]]},"references-count":65,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,10,1]]}},"alternative-id":["10.1152\/ajpgi.00223.2026"],"URL":"https:\/\/doi.org\/10.1152\/ajpgi.00223.2026","relation":{},"ISSN":["0193-1857","1522-1547"],"issn-type":[{"value":"0193-1857","type":"print"},{"value":"1522-1547","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,1]]},"assertion":[{"value":"2026-07-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-14","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}