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We show that the elongase Elovl3 is a novel Zhx2 target. Elovl3 and Zhx2 expression change during liver regeneration, which is associated with changes in very long chain fatty acids. Forced Elovl3 expression reduces cell growth and blocks cell cycle progression. This suggests that Elovl3 may account, at least in part, for the relationship between Zhx2 and proliferation during liver development and disease.<\/jats:p>","DOI":"10.1152\/ajpgi.00235.2022","type":"journal-article","created":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T13:27:30Z","timestamp":1697549250000},"page":"G582-G592","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Elongation of very long chain fatty acids-3 (\n                    <i>Elovl3<\/i>\n                    ) is activated by ZHX2 and is a regulator of cell cycle progression"],"prefix":"10.1152","volume":"325","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1870-4586","authenticated-orcid":false,"given":"Kate Townsend","family":"Creasy","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Nutritional Sciences, University of Kentucky College of Medicine, Lexington, Kentucky, United 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