{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T09:36:34Z","timestamp":1778924194844,"version":"3.51.4"},"reference-count":43,"publisher":"American Physiological Society","issue":"2","funder":[{"DOI":"10.13039\/501100006197","name":"A.P. M\u00f8ller Fonden | Fonden til L\u00e6gevidenskabens Fremme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006197","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003035","name":"Aase og Ejnar Danielsens Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003035","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004954","name":"Augustinus Fonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004954","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008244","name":"Direkt\u00f8r Jacob Madsen og Hustru Olga Madsens Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008244","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008274","name":"P. A. Messerschmidt og Hustrus Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008274","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007437","name":"TrygFonden","doi-asserted-by":"publisher","award":["ID 101390 and ID 20045"],"award-info":[{"award-number":["ID 101390 and ID 20045"]}],"id":[{"id":"10.13039\/501100007437","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001732","name":"Danish National Research Foundation","doi-asserted-by":"crossref","award":["DNRF55"],"award-info":[{"award-number":["DNRF55"]}],"id":[{"id":"10.13039\/501100001732","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"published-print":{"date-parts":[[2023,8,1]]},"abstract":"<jats:p> Muscle protein turnover responses to parenteral nutritional (PN) supplementation have not previously been studied in stable alcoholic liver cirrhosis (ALC). We applied stable isotope tracers of amino acids to directly quantify net muscle protein turnover responses to PN in sarcopenic males with ALC and healthy controls. We found a higher net muscle protein gain in ALC during PN, thereby providing the physiological rationale for future clinical trials of PN as a potential countermeasure to sarcopenia. <\/jats:p>","DOI":"10.1152\/ajpgi.00242.2022","type":"journal-article","created":{"date-parts":[[2023,6,21]],"date-time":"2023-06-21T02:46:50Z","timestamp":1687315610000},"page":"G174-G183","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Skeletal muscle protein turnover responses to parenteral nutrition in patients with alcoholic liver cirrhosis and sarcopenia"],"prefix":"10.1152","volume":"325","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8140-2583","authenticated-orcid":false,"given":"Ulrik Winning","family":"Iepsen","sequence":"first","affiliation":[{"name":"The Centre for Physical Activity Research, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark"},{"name":"Department of Anaesthesiology and Intensive Care, Copenhagen University Hospital\u2014Hvidovre Hospital, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3859-3289","authenticated-orcid":false,"given":"Anders Rasmussen","family":"Rinnov","sequence":"additional","affiliation":[{"name":"The Centre for Physical Activity Research, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregers Winding","family":"Munch","sequence":"additional","affiliation":[{"name":"The Centre for Physical Activity Research, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mette","family":"Rugbjerg","sequence":"additional","affiliation":[{"name":"The Centre for Physical Activity Research, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamilla Munch","family":"Winding","sequence":"additional","affiliation":[{"name":"The Centre for Physical Activity Research, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carsten","family":"Lauridsen","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark"},{"name":"Department of Technology, Copenhagen University College, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5757-9506","authenticated-orcid":false,"given":"Ronan M. G.","family":"Berg","sequence":"additional","affiliation":[{"name":"The Centre for Physical Activity Research, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark"},{"name":"Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark"},{"name":"Department of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark"},{"name":"Neurovascular Research Laboratory, Faculty of Life Sciences and Education, University of South Wales, Pontypridd, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bente Klarlund","family":"Pedersen","sequence":"additional","affiliation":[{"name":"The Centre for Physical Activity Research, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lise Lotte","family":"Gluud","sequence":"additional","affiliation":[{"name":"Gastro Unit, Hvidovre Hospital, University of Copenhagen, Hvidovre, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerrit","family":"van Hall","sequence":"additional","affiliation":[{"name":"Clinical Metabolomics Core Facility, Clinical Biochemistry, Copenhagen University Hospital, Copenhagen, Denmark"},{"name":"Department of Biomedical Sciences, Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/J.CGH.2011.08.028"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1093\/AGEING\/AFY169"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1002\/HEP.32049"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29602"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/J.JHEP.2021.01.025"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1074\/JBC.RA118.005411"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1152\/AJPGI.00373.2020"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1172\/JCI110240"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1002\/HEP.1840120117"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1172\/JCI111142"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(98)70033-2"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/J.NUT.2013.01.022"},{"key":"B13","first-page":"1123","volume":"76","author":"Noda C","year":"1974","journal-title":"J Biochem"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1152\/AJPLEGACY.1965.209.5.1046"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1002\/HEP.1840080509"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1136\/GUT.23.5.362"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1152\/AJPENDO.1994.267.1.E140-149"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1002\/HEP.510280526"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1042\/CS0780613"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1152\/AJPENDO.00333.2001"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1002\/HEP.1840060412"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1002\/HEP.27717"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1210\/JC.2016-1923"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00178.2017"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1080\/00365517509095787"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1002\/JMS.3387"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2014.01.019"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1152\/AJPENDO.1992.263.5.E1010"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1210\/JCEM.86.2.7193"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2016.06.007"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1038\/emm.2015.97"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1152\/AJPGI.00062.2011"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.3109\/00365513.2015.1074276"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.3390\/IJMS21155357"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1186\/S12970-017-0184-9"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1111\/JOIM.12462"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.2337\/DB10-1806"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1152\/AJPGI.00278.2004"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1172\/JCI111873"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1002\/HEP.510280119"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(82)90103-2"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(93)90650-2"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1152\/AJPGI.00355.2007"}],"container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpgi.00242.2022","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T12:24:10Z","timestamp":1690892650000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpgi.00242.2022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,1]]},"references-count":43,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,8,1]]}},"alternative-id":["10.1152\/ajpgi.00242.2022"],"URL":"https:\/\/doi.org\/10.1152\/ajpgi.00242.2022","relation":{},"ISSN":["0193-1857","1522-1547"],"issn-type":[{"value":"0193-1857","type":"print"},{"value":"1522-1547","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,1]]},"assertion":[{"value":"2022-10-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-27","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}