{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T11:03:36Z","timestamp":1785409416560,"version":"3.56.0"},"reference-count":40,"publisher":"American Physiological Society","issue":"5","funder":[{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["DK124182"],"award-info":[{"award-number":["DK124182"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["DK57993"],"award-info":[{"award-number":["DK57993"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015724","name":"The Mayo Clinic | Center for Cell Signaling in Gastroenterology, Mayo Clinic","doi-asserted-by":"publisher","award":["P30DK084567"],"award-info":[{"award-number":["P30DK084567"]}],"id":[{"id":"10.13039\/100015724","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000871","name":"Mayo Clinic","doi-asserted-by":"publisher","award":["Chris M. Carlos and Catharine Nicole Jockisch Carlos Endowment Fund"],"award-info":[{"award-number":["Chris M. Carlos and Catharine Nicole Jockisch Carlos Endowment Fund"]}],"id":[{"id":"10.13039\/100000871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"published-print":{"date-parts":[[2025,11,1]]},"abstract":"<jats:p>\n                    Cholangiocyte pathophysiological activation was examined in a model of murine cholestasis. CX3CR1\n                    <jats:sup>+<\/jats:sup>\n                    macrophages are recruited to the periportal region, likely mediated by cholangiocyte expression of CX3CL1. Cholangiocyte transcriptomics from cholestatic mice display activation of a \u201cpathogen-induced cytokine storm\u201d pathway, and exhibit activation of the transcription factor NF-Y. In human cholangiocytes, NF-Y promotes expression of the profibrogenic ligand TGF\u03b21. These observations provide insights into the cholestatic cholangiocyte pathobiology contributing to periductal inflammation and fibrosis.\n                  <\/jats:p>","DOI":"10.1152\/ajpgi.00243.2025","type":"journal-article","created":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T18:21:17Z","timestamp":1759170077000},"page":"G597-G613","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Dynamic cholangiocyte responses in a murine model of reversible cholestasis: macrophage remodeling and NF-Y-mediated TGF\u03b21 expression"],"prefix":"10.1152","volume":"329","author":[{"given":"Kirsta E.","family":"Olson","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02qp3tb03","id-type":"ROR","asserted-by":"publisher"}],"name":"Mayo Clinic","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anuradha","family":"Krishnan","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02qp3tb03","id-type":"ROR","asserted-by":"publisher"}],"name":"Mayo Clinic","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Splinter","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02qp3tb03","id-type":"ROR","asserted-by":"publisher"}],"name":"Mayo Clinic","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2982-7303","authenticated-orcid":false,"given":"Alexander Q.","family":"Wixom","sequence":"additional","affiliation":[{"name":"Mayo Clinic","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4579-2753","authenticated-orcid":false,"given":"Maria Eugenia","family":"Guicciardi","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02qp3tb03","id-type":"ROR","asserted-by":"publisher"}],"name":"Mayo Clinic","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6795-0121","authenticated-orcid":false,"given":"Nidhi","family":"Jalan-Sakrikar","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02qp3tb03","id-type":"ROR","asserted-by":"publisher"}],"name":"Mayo Clinic","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adiba","family":"Azad","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02qp3tb03","id-type":"ROR","asserted-by":"publisher"}],"name":"Mayo Clinic","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3266-0831","authenticated-orcid":false,"given":"Nicholas F.","family":"LaRusso","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02qp3tb03","id-type":"ROR","asserted-by":"publisher"}],"name":"Mayo Clinic","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3151-009X","authenticated-orcid":false,"given":"Gregory J.","family":"Gores","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02qp3tb03","id-type":"ROR","asserted-by":"publisher"}],"name":"Mayo Clinic","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2015.03.017"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1097\/HEP.0000000000001093"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2023.02.012"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2025-334763"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2024.07.044"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1192840"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1097\/HEP.0000000000000557"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2016.459"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1097\/HC9.0000000000000491"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30706"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2007.061133"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-024-01687-w"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-52710-3"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31211"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0114804"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp616"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btx364"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1093\/nargab\/lqae098"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1038\/s41596-020-0336-2"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.1994.266.6.G1060"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1111\/liv.14569"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.05.018"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2022.08.002"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2025.01.002"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhepr.2024.101196"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.3390\/cells8101184"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2022.155272"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2024.167130"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-025-02190-y"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagrm.2019.194472"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2024.189082"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagrm.2016.12.005"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygeno.2024.110895"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2005.04.001"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv568"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23894"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1097\/HC9.0000000000000454"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.7150\/jca.47022"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.08.024"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-025-01190-9"}],"container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpgi.00243.2025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T18:30:24Z","timestamp":1763749824000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpgi.00243.2025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,1]]},"references-count":40,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,11,1]]}},"alternative-id":["10.1152\/ajpgi.00243.2025"],"URL":"https:\/\/doi.org\/10.1152\/ajpgi.00243.2025","relation":{},"ISSN":["0193-1857","1522-1547"],"issn-type":[{"value":"0193-1857","type":"print"},{"value":"1522-1547","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,1]]},"assertion":[{"value":"2025-07-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-14","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}