{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T18:58:07Z","timestamp":1697309887911},"reference-count":42,"publisher":"American Physiological Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"published-print":{"date-parts":[[2006,1]]},"abstract":"<jats:p>Reduced fasting or postprandial gastric volumes have been implicated in the pathophysiology of functional dyspepsia. The mechanisms that underlie the control of gastric fundic volume are incompletely understood, partly because of an inability to accurately measure fundic volume in vivo in small animals. Small animals are useful models to evaluate mechanisms, e.g., in knockout animals. The aim of this study was to determine whether an ultrasonometric technique accurately monitors fundic contraction and relaxation in mice in vivo and to determine the effect of modulation of cholinergic, nitrergic, and serotonergic pathways on fundic size and compliance in the intact mouse innervated stomach. Two to four piezoelectric crystals (diameter 1 mm, 24-\u03bcm resolution) were glued to the serosal side of fundus and used to measure distance. Validation studies showed excellent correlation between measured changes and actual changes in distances between crystals and excellent reproducibility. The expected responses to pharmacological modulation with bethanechol and nitroglycerin were demonstrated. Atropine increased the distance between the crystals, suggesting a baseline cholinergic regulation of fundic volume. Bethanechol, N<jats:sup>\u03c9<\/jats:sup>-nitro-l-arginine, and the 5-HT<jats:sub>1B\/D<\/jats:sub>agonist sumatriptan decreased the distance between the crystals, suggesting fundic contraction. Atropine, nitroglycerin, and buspirone caused an increase in intercrystal distance consistent with fundic relaxation. Fundic compliance was investigated by changing intragastric pressure via an implanted catheter. Sumatriptan increased compliance, whereas buspirone increased the distance between crystals but did not change compliance. The data suggest that ultrasonomicrometry is a useful tool that can reproducibly and accurately measure changes in fundic size and the response to pharmacological agents.<\/jats:p>","DOI":"10.1152\/ajpgi.00244.2005","type":"journal-article","created":{"date-parts":[[2005,9,16]],"date-time":"2005-09-16T00:33:58Z","timestamp":1126830838000},"page":"G74-G82","source":"Crossref","is-referenced-by-count":7,"title":["Effect of modulation of serotonergic, cholinergic, and nitrergic pathways on murine fundic size and compliance measured by ultrasonomicrometry"],"prefix":"10.1152","volume":"290","author":[{"given":"Lin","family":"Xue","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. Richard","family":"Locke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Camilleri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan A. J.","family":"Schuurkes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann","family":"Meulemans","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernard J.","family":"Coulie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph H.","family":"Szurszewski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianrico","family":"Farrugia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"R1","unstructured":"Adelson DWand Million M.Tracking the moveable feast: sonomicrometry and gastrointestinal motility.News Physiol Sci19: 27\u201332, 2004."},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00057.2003"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(87)90967-X"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.1986.251.6.G727"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(01)00973-0"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1006\/phrs.1997.0168"},{"key":"R7","doi-asserted-by":"crossref","unstructured":"Berstad A.Today\u2019s therapy of functional gastrointestinal disorders\u2013does it help?Eur J Surg Suppl: 92\u201397, 1998.","DOI":"10.1080\/11024159850191328"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2002.05421.x"},{"key":"R9","doi-asserted-by":"crossref","unstructured":"Cannon WB, Lieb CW.The receptive relaxation of the stomach.Am J Physiol29: 267\u2013273. 1911.","DOI":"10.1152\/ajplegacy.1911.29.2.267"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3908(97)00094-4"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.1999.276.2.G373"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00280.2002"},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2004.00497.x"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1038\/351477a0"},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00368.2003"},{"key":"R16","doi-asserted-by":"crossref","unstructured":"Friedman G.Treatment of the irritable bowel syndrome.Gastroenterol Clin North Am20: 325\u2013333, 1991.","DOI":"10.1016\/S0889-8553(21)00554-9"},{"key":"R17","doi-asserted-by":"publisher","DOI":"10.1021\/bi00084a017"},{"key":"R18","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(82)90271-8"},{"key":"R19","unstructured":"Gershon MD.The enteric nervous system: a second brain.Hosp Pract (Off Ed)34: 31\u201332, 35\u201338, and 41\u201332 passim, 1999."},{"key":"R20","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2004.06.008"},{"key":"R21","doi-asserted-by":"crossref","unstructured":"Grey E.Observations on the postural activity of the stomach.Am J Physiol45: 272\u2013285, 1918.","DOI":"10.1152\/ajplegacy.1918.45.3.272"},{"key":"R22","unstructured":"Guth BD, Schulz R, and Heusch G.Time course and mechanisms of contractile dysfunction during acute myocardial ischemia.Circulation87: IV35\u2013IV42, 1993."},{"key":"R23","doi-asserted-by":"publisher","DOI":"10.1006\/jmcc.2000.1294"},{"key":"R24","unstructured":"Hoyer D, Clarke DE, Fozard JR, Hartig PR, Martin GR, Mylecharane EJ, Saxena PR, and Humphrey PP.International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin).Pharmacol Rev46: 157\u2013203, 1994."},{"key":"R25","doi-asserted-by":"crossref","unstructured":"Jahnberg T, Abrahamsson H, Jansson G, and Martinson J.Gastric relaxatory response to feeding before and after vagotomy.Scand J Gastroenterol12: 225\u2013228, 1977.","DOI":"10.1080\/00365521.1977.12031139"},{"key":"R26","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0703274"},{"key":"R27","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(92)94816-E"},{"key":"R28","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118781"},{"key":"R29","doi-asserted-by":"publisher","DOI":"10.3109\/00365528309181574"},{"key":"R30","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2982.2003.00464.x"},{"key":"R31","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0703174"},{"key":"R32","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(92)91454-C"},{"key":"R33","doi-asserted-by":"publisher","DOI":"10.1136\/gut.51.2.219"},{"key":"R34","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(98)70012-5"},{"key":"R35","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1997.479be.x"},{"key":"R36","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.1998.275.2.G314"},{"key":"R37","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1999.1130_f.x"},{"key":"R38","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-04-01393.2000"},{"key":"R39","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-197309000-00009"},{"key":"R40","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.4.1851"},{"key":"R41","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2003.1240580"},{"key":"R42","unstructured":"Yuan R, Sumi M, and Benet LZ.Investigation of aortic CYP3A bioactivation of nitroglycerin in vivo.J Pharmacol Exp Ther281: 1499\u20131505, 1997."}],"container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajpgi.00244.2005","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,17]],"date-time":"2021-07-17T16:57:28Z","timestamp":1626541048000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajpgi.00244.2005"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,1]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,1]]}},"alternative-id":["10.1152\/ajpgi.00244.2005"],"URL":"https:\/\/doi.org\/10.1152\/ajpgi.00244.2005","relation":{},"ISSN":["0193-1857","1522-1547"],"issn-type":[{"value":"0193-1857","type":"print"},{"value":"1522-1547","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,1]]}}}