{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T16:00:20Z","timestamp":1788192020151,"version":"build-2803163510"},"reference-count":83,"publisher":"American Physiological Society","issue":"5","funder":[{"name":"NIH","award":["K08DK100661"],"award-info":[{"award-number":["K08DK100661"]}]},{"name":"NIH","award":["R03DK110579"],"award-info":[{"award-number":["R03DK110579"]}]},{"name":"NIH","award":["P30 DK063491"],"award-info":[{"award-number":["P30 DK063491"]}]},{"name":"UCLA Children&apos;s Discovery and Innovation Institute","award":["Seed Grant"],"award-info":[{"award-number":["Seed Grant"]}]},{"name":"UCLA Children&apos;s Discovery and Innovation Institute","award":["Today&apos;s and Tomorrow&apos;s Children Fund"],"award-info":[{"award-number":["Today&apos;s and Tomorrow&apos;s Children Fund"]}]},{"name":"NIH","award":["R01HL113350"],"award-info":[{"award-number":["R01HL113350"]}]},{"name":"NIH","award":["P30 DK063491"],"award-info":[{"award-number":["P30 DK063491"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"published-print":{"date-parts":[[2020,5,1]]},"abstract":"<jats:p>This work provides evidence that Helicobacter pylori decreases levels of Na-K-ATPase, a vital transport enzyme, in gastric epithelia, both in acutely infected cultured cells and in chronically infected patients and animals. The bacteria interfere with BiP-assisted folding of newly-made Na-K-ATPase subunits in the endoplasmic reticulum, accelerating their ubiquitylation and proteasomal degradation and decreasing efficiency of the assembly of native enzyme. Decreased Na-K-ATPase expression contributes to H. pylori-induced gastric injury.<\/jats:p>","DOI":"10.1152\/ajpgi.00266.2019","type":"journal-article","created":{"date-parts":[[2020,3,16]],"date-time":"2020-03-16T11:14:01Z","timestamp":1584357241000},"page":"G931-G945","source":"Crossref","is-referenced-by-count":11,"title":["<i>Helicobacter pylori<\/i>infection impairs chaperone-assisted maturation of Na-K-ATPase in gastric epithelium"],"prefix":"10.1152","volume":"318","author":[{"given":"Elizabeth A.","family":"Marcus","sequence":"first","affiliation":[{"name":"Department of Pediatrics, David Geffen School of Medicine, University of California, Los Angeles, California"},{"name":"Veterans Affairs Greater Los Angeles Health Care System, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elmira","family":"Tokhtaeva","sequence":"additional","affiliation":[{"name":"Department of Physiology, David Geffen School of Medicine, University of California, Los Angeles, California"},{"name":"Veterans Affairs Greater Los Angeles Health Care System, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jossue L.","family":"Jimenez","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, David Geffen School of Medicine, University of California, Los Angeles, California"},{"name":"Veterans Affairs Greater Los Angeles Health Care System, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Physiology, David Geffen School of Medicine, University of California, Los Angeles, California"},{"name":"Veterans Affairs Greater Los Angeles Health Care System, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bita V.","family":"Naini","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley N.","family":"Heard","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, David Geffen School of Medicine, University of California, Los Angeles, California"},{"name":"Veterans Affairs Greater Los Angeles Health Care System, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Kim","sequence":"additional","affiliation":[{"name":"Veterans Affairs Greater Los Angeles Health Care System, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Capri","sequence":"additional","affiliation":[{"name":"Pasarow Mass Spectrometry Laboratory, The Neuropsychiatric Insititute\u2013Semel Institute, University of California, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Whitaker","family":"Cohn","sequence":"additional","affiliation":[{"name":"Pasarow Mass Spectrometry Laboratory, The Neuropsychiatric Insititute\u2013Semel Institute, University of California, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian P.","family":"Whitelegge","sequence":"additional","affiliation":[{"name":"Pasarow Mass Spectrometry Laboratory, The Neuropsychiatric Insititute\u2013Semel Institute, University of California, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Vagin","sequence":"additional","affiliation":[{"name":"Department of Physiology, David Geffen School of Medicine, University of California, Los Angeles, California"},{"name":"Veterans Affairs Greater Los Angeles Health Care System, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1970.tb02226.x"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(90)81130-G"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1128\/JB.01416-08"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.34.20895"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1997.tb52311.x"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.11.5.1657"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.1998.275.5.F633"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(92)90126-J"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1996.260"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2009.21"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1007\/s004240000363"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.20124"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.517003"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2017.00371"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(97)00182-8"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(75)90498-5"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.12.5791"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.3.1976"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2007.04.013"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M201326200"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1021\/bi0007831"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1159\/000199597"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003840.pub2"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.117.4.841"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1097\/MNH.0b013e3283036cbf"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD004062.pub2"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2009.192757"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00050.2006"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C111.333419"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1038\/embor.2010.114"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.233601"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.65.092101.142558"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1016\/j.bj.2015.06.002"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.71.102201.141218"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2008-0365OC"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2007.00541.x"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2001.01109.x"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2015.00066"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00209.2013"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(84)91816-6"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2016.00179"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.2001.281.4.C1355"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(91)80318-W"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2736(76)90277-7"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199110173251604"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-3603-8_24"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2008.05762.x"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e10-01-0081"},{"key":"B49","first-page":"60","volume":"161","author":"Parsonnet J","year":"1994","journal-title":"West J Med"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199110173251603"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.12.12.3717"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2007.261"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-012-1039-9"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(93)81703-3"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1093\/database\/baw100"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2008.73"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-3-31"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e04-03-0267"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3002(57)90343-8"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra020542"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4157(89)90019-1"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.13.13.1751"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1021\/bi100115a"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.252247"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.100149"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1021\/bi901438z"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.172858"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.186148"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1248\/yakushi1947.120.10_935"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21262"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1008302107"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1159\/000331520"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks596"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1172\/JCI29723"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1378\/chest.11-1660"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M606507200"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M704713200"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M508262200"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.10.5921-5939.2003"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1172\/JCI11596"},{"key":"B81","first-page":"177","volume-title":"IARC Monographs on the Evaluation of the Carcinogenic Risk to Humans. Schistosomes, Liver Flukes, and Helicobacter Pylori","volume":"61","author":"World Health Organization","year":"1994"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-1033.2002.02910.x"},{"key":"B83","doi-asserted-by":"crossref","first-page":"17707","DOI":"10.1016\/S0021-9258(19)47429-2","volume":"266","author":"Yoshimori T","year":"1991","journal-title":"J Biol Chem"}],"container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpgi.00266.2019","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,4]],"date-time":"2021-03-04T11:48:56Z","timestamp":1614858536000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpgi.00266.2019"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,1]]},"references-count":83,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,5,1]]}},"alternative-id":["10.1152\/ajpgi.00266.2019"],"URL":"https:\/\/doi.org\/10.1152\/ajpgi.00266.2019","relation":{},"ISSN":["0193-1857","1522-1547"],"issn-type":[{"value":"0193-1857","type":"print"},{"value":"1522-1547","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,1]]}}}