{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T21:39:04Z","timestamp":1791581944860,"version":"4.3.4"},"reference-count":69,"publisher":"American Physiological Society","issue":"3","funder":[{"DOI":"10.13039\/501100000925","name":"Department of Health, Australian Government | National Health and Medical Research Council (NHMRC)","doi-asserted-by":"publisher","award":["APP1126378"],"award-info":[{"award-number":["APP1126378"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"Department of Health, Australian Government | National Health and Medical Research Council (NHMRC)","doi-asserted-by":"publisher","award":["1083480"],"award-info":[{"award-number":["1083480"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"Department of Health, Australian Government | National Health and Medical Research Council (NHMRC)","doi-asserted-by":"publisher","award":["1140297"],"award-info":[{"award-number":["1140297"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"Department of Health, Australian Government | National Health and Medical Research Council (NHMRC)","doi-asserted-by":"publisher","award":["1139366"],"award-info":[{"award-number":["1139366"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"Department of Health, Australian Government | National Health and Medical Research Council (NHMRC)","doi-asserted-by":"publisher","award":["1140297"],"award-info":[{"award-number":["1140297"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"published-print":{"date-parts":[[2018,3,1]]},"abstract":"<jats:p>Chronic abdominal and pelvic pain are common debilitating clinical conditions experienced by millions of patients around the globe. The origin of such pain commonly arises from the intestine and bladder, which share common primary roles (the collection, storage, and expulsion of waste). These visceral organs are located in close proximity to one another and also share common innervation from spinal afferent pathways. Chronic abdominal pain, constipation, or diarrhea are primary symptoms for patients with irritable bowel syndrome or inflammatory bowel disease. Chronic pelvic pain and urinary urgency and frequency are primary symptoms experienced by patients with lower urinary tract disorders such as interstitial cystitis\/painful bladder syndrome. It is becoming clear that these symptoms and clinical entities do not occur in isolation, with considerable overlap in symptom profiles across patient cohorts. Here we review recent clinical and experimental evidence documenting the existence of \u201ccross-organ sensitization\u201d between the colon and bladder. In such circumstances, colonic inflammation may result in profound changes to the sensory pathways innervating the bladder, resulting in severe bladder dysfunction.<\/jats:p>","DOI":"10.1152\/ajpgi.00272.2017","type":"journal-article","created":{"date-parts":[[2017,11,16]],"date-time":"2017-11-16T14:50:20Z","timestamp":1510843820000},"page":"G301-G308","source":"Crossref","is-referenced-by-count":70,"title":["Cross-organ sensitization between the colon and bladder: to pee or not to pee?"],"prefix":"10.1152","volume":"314","author":[{"given":"Luke","family":"Grundy","sequence":"first","affiliation":[{"name":"Visceral Pain Research Group, Human Physiology, Centre for Neuroscience, College of Medicine and Public Health, Flinders University, Bedford Park, South Australia, Australia"},{"name":"Centre for Nutrition and Gastrointestinal Diseases, Discipline of Medicine, University of Adelaide, South Australian Health and Medical Research Institute, North Terrace, Adelaide, South Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart M.","family":"Brierley","sequence":"additional","affiliation":[{"name":"Visceral Pain Research Group, Human Physiology, Centre for Neuroscience, College of Medicine and Public Health, Flinders University, Bedford Park, South Australia, Australia"},{"name":"Centre for Nutrition and Gastrointestinal Diseases, Discipline of Medicine, University of Adelaide, South Australian Health and Medical Research Institute, North Terrace, Adelaide, South Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2002.125704"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(99)80332-X"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2015.34"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2003.11.055"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00154.2004"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.3390\/ph3092768"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2014.103"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2015-310971"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.08.017"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2006.09.023"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)00351-4"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1111\/bju.12266"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410X.1997.00172.x"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2013.05.445"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms4165"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1838(81)90059-X"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.4161\/org.25895"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2016.14"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2012.09.002"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1023\/A:1018838507545"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/120525"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2015.02.2944"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(16)30506-6"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-9-27"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1002\/cne.23042"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2008.170811"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2013.120"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1838(90)90108-U"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0076779"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2015.150"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1111\/ijcp.12028"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2015.12.090"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcmj.2015.09.006"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00353.2005"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2012.01910.x"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-10-3"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1002\/nau.20410"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200412030-00008"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2006.00807.x"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2012.11591.x"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2005.04.002"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00311.2007"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1038\/nature17976"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2010.05.012"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0094872"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-015-0296-0"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1007\/BF01536698"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2006.12.024"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1002\/cne.10447"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200403010-00017"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.09.013"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-007-9835-z"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.07.003"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-009-9647-5"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00395.2005"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00162.2006"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-0618(00)00115-0"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1186\/1744-8069-7-31"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(02)01784-3"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1136\/gut.27.9.1014"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00455.2006"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2016.03.007"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2015.12.006"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-9-30"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2014.08.064"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.4111\/kju.2014.55.2.81"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1111\/iju.12308"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2012.08.007"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1186\/1756-6606-4-31"}],"container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajpgi.00272.2017","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,20]],"date-time":"2019-09-20T08:43:15Z","timestamp":1568968995000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajpgi.00272.2017"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,1]]},"references-count":69,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,3,1]]}},"alternative-id":["10.1152\/ajpgi.00272.2017"],"URL":"https:\/\/doi.org\/10.1152\/ajpgi.00272.2017","relation":{},"ISSN":["0193-1857","1522-1547"],"issn-type":[{"value":"0193-1857","type":"print"},{"value":"1522-1547","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,1]]}}}