{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T01:31:15Z","timestamp":1769045475055,"version":"3.49.0"},"reference-count":19,"publisher":"American Physiological Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"published-print":{"date-parts":[[2004,3]]},"abstract":"<jats:p> Biliary duct obstruction is an important clinical condition that stems from cholelithiasis, the neoplasm in the wall or, most commonly, gallbladder stones. The objective of this study is to understand the structural and mechanical remodeling of the common bile duct (CBD) postobstruction. Porcine CBD was ligated near the duodenum that increased the duct's pressure from 6.4 to 18.3 cmH<jats:sub>2<\/jats:sub>O in the first 12 h and to 30.7 cmH<jats:sub>2<\/jats:sub>O after 32 days. The remodeling process was studied after 3 h, 12 h, 2 days, 8 days, and 32 days ( n = 5 in each group) after obstruction. One additional animal in each group was sham operated. At each scheduled time, the time course of change of morphometry (diameter, length, wall thickness, etc.) and mechanical properties (stress, strain, etc.) was documented. It was found that the diameter increased by about threefold and the wall thickness of the CBD doubled in the 32-day group compared with the sham group ( P &lt; 0.001). The stress and strain increased initially with increase in pressure but recovered to near the control values by day 32 due to the structural and mechanical adaptations. Hence, the net effect of the structural and mechanical remodeling is to restore the stress and strain to their homeostatic values. Furthermore, the strain recovers more rapidly and more completely than stress. Finally, the remodeling data were expressed mathematically in terms of indicial response functions (IRF), i.e., change of a particular feature of a CBD in response to a unit step change of the pressure. The IRF approach provides a quantitative description of the remodeling process in the CBD. <\/jats:p>","DOI":"10.1152\/ajpgi.00306.2003","type":"journal-article","created":{"date-parts":[[2004,2,6]],"date-time":"2004-02-06T18:48:15Z","timestamp":1076093295000},"page":"G420-G427","source":"Crossref","is-referenced-by-count":16,"title":["Indicial response functions of growth and remodeling of common bile duct postobstruction"],"prefix":"10.1152","volume":"286","author":[{"given":"Quang","family":"Dang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans","family":"Gregersen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birgitte","family":"Duch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ghassan S.","family":"Kassab","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"REF1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(05)80014-5"},{"key":"REF2","unstructured":"Carlson E, Zukoski CF, Campbell J, and Chvapil M. Morphologic, biophysical, and biochemical consequences of ligation of the common biliary duct in the dog. Am J Pathol 86: 301-320, 1977."},{"key":"REF3","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2982.2002.00310.x"},{"key":"REF4","unstructured":"Fung YC. The Theory of Aeroelasticity. New York: Dover Publications, 1993."},{"key":"REF5","doi-asserted-by":"publisher","DOI":"10.1114\/1.109"},{"key":"REF6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.1996.tb00267.x"},{"key":"REF7","doi-asserted-by":"publisher","DOI":"10.1023\/A:1005649520386"},{"key":"REF8","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-200212000-00023"},{"key":"REF9","doi-asserted-by":"publisher","DOI":"10.1114\/1.1470181"},{"key":"REF10","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1996.270.4.H1323"},{"key":"REF11","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.2001.280.4.H1547"},{"key":"REF12","doi-asserted-by":"publisher","DOI":"10.1115\/1.2895731"},{"key":"REF13","doi-asserted-by":"publisher","DOI":"10.1097\/00004424-198505000-00009"},{"key":"REF14","unstructured":"Roslyn JJ and DenBesten L. Gallstones and cholecyctitis. In: Surgical Treatment of Digestive Disease, edited by Moody F. Chicago, IL: Year Book Medical, 1990."},{"key":"REF15","doi-asserted-by":"publisher","DOI":"10.1002\/jcu.1870090207"},{"key":"REF16","unstructured":"Sherlock S and Dooley J. Diseases of the Liver and Biliary System (10th ed.). London: Blackwell Science, 1997."},{"key":"REF17","unstructured":"Vaishnav RN, Vossoughi J, Patel DJ, Cothran LN, Coleman BR, and Ison-Franklin EL. Effect of hypertension on elasticity and geometry of aortic tissue from dogs. J Biomech Eng 11: 270-274, 1990."},{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.28.6.622"},{"key":"REF19","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.30.3.301"}],"container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajpgi.00306.2003","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T20:37:52Z","timestamp":1567975072000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajpgi.00306.2003"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,3]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2004,3]]}},"alternative-id":["10.1152\/ajpgi.00306.2003"],"URL":"https:\/\/doi.org\/10.1152\/ajpgi.00306.2003","relation":{},"ISSN":["0193-1857","1522-1547"],"issn-type":[{"value":"0193-1857","type":"print"},{"value":"1522-1547","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,3]]}}}