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Disruption of this process has significant consequences for gastrointestinal, liver and whole body homeostasis and therefore offers opportunities for therapeutic intervention. In this review we discuss the effects of (pharmacological) interruption of the enterohepatic circulation at different levels. Recently, several studies have been published on ileal interruption of the enterohepatic circulation of bile acids, targeting the apical-sodium dependent bile acid transporter (ASBT, SLC10A2), as therapy for various diseases. However, ambiguous results have been reported and in-depth mechanistic insights are lacking. Here we discuss these novel studies and review the current knowledge on the consequences of ASBT inhibition and its potential effects on physiology and metabolism.<\/jats:p>","DOI":"10.1152\/ajpgi.00308.2020","type":"journal-article","created":{"date-parts":[[2020,9,16]],"date-time":"2020-09-16T21:41:47Z","timestamp":1600292507000},"page":"G619-G625","source":"Crossref","is-referenced-by-count":38,"title":["Metabolic consequences of ileal interruption of the enterohepatic circulation of bile acids"],"prefix":"10.1152","volume":"319","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6268-3404","authenticated-orcid":false,"given":"Ivo P.","family":"van de Peppel","sequence":"first","affiliation":[{"name":"Section of Molecular Metabolism and Nutrition, Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henkjan 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