{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T00:56:42Z","timestamp":1775177802005,"version":"3.50.1"},"reference-count":44,"publisher":"American Physiological Society","issue":"2","funder":[{"DOI":"10.13039\/501100001691","name":"MEXT | Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["18K08019"],"award-info":[{"award-number":["18K08019"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005845","name":"Hyogo College of Medicine","doi-asserted-by":"publisher","award":["S1411041"],"award-info":[{"award-number":["S1411041"]}],"id":[{"id":"10.13039\/501100005845","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005845","name":"Hyogo College of Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005845","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005845","name":"Hyogo College of Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005845","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science, and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"published-print":{"date-parts":[[2021,2,1]]},"abstract":"<jats:p>We showed for the first time that neonatal MS stress-induced FD rats undergo gastroduodenal eosinophil-associated microinflammation in adulthood. Suppression of microinflammation attenuated gastric hypersensitivity in MS rats. These findings established a functional link between microinflammation and gastric hypersensitivity, which may provide a potential clue for the clinical treatment of FD.<\/jats:p>","DOI":"10.1152\/ajpgi.00313.2020","type":"journal-article","created":{"date-parts":[[2020,11,11]],"date-time":"2020-11-11T12:16:34Z","timestamp":1605096994000},"page":"G206-G216","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":12,"title":["Eosinophil-associated microinflammation in the gastroduodenal tract contributes to gastric hypersensitivity in a rat model of early-life adversity"],"prefix":"10.1152","volume":"320","author":[{"given":"Shaoqi","family":"Duan","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan"},{"name":"Department of Pharmacy, School of Pharmacy, Hyogo University of Health Sciences, Kobe, Japan"},{"name":"Traditional Medicine Research Center, Chinese Medicine Confucius Institute at Hyogo College of Medicine (CMCIHCM), Kobe, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Kondo","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroto","family":"Miwa","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan"},{"name":"Traditional Medicine Research Center, Chinese Medicine Confucius Institute at Hyogo College of Medicine (CMCIHCM), Kobe, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanjing","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, School of Pharmacy, Hyogo University of Health Sciences, Kobe, Japan"},{"name":"Traditional Medicine Research Center, Chinese Medicine Confucius Institute at Hyogo College of Medicine (CMCIHCM), Kobe, Japan"},{"name":"Department of Anatomy and Neuroscience, Hyogo College of Medicine, Nishinomiya, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shenglan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, School of Pharmacy, Hyogo University of Health Sciences, Kobe, Japan"},{"name":"School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine (BUCM), Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirosato","family":"Kanda","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, School of Pharmacy, Hyogo University of Health Sciences, Kobe, Japan"},{"name":"Traditional Medicine Research Center, Chinese Medicine Confucius Institute at Hyogo College of Medicine (CMCIHCM), Kobe, Japan"},{"name":"Department of Anatomy and Neuroscience, Hyogo College of Medicine, Nishinomiya, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoko","family":"Kogure","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, School of Pharmacy, Hyogo University of Health Sciences, Kobe, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuko","family":"Imamura","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadahiro","family":"Fujimura","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoaki","family":"Kono","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masashi","family":"Fukushima","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuyuki","family":"Tozawa","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshihiko","family":"Tomita","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6949-932X","authenticated-orcid":false,"given":"Tadayuki","family":"Oshima","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirokazu","family":"Fukui","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, School of Pharmacy, Hyogo University of Health Sciences, Kobe, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Noguchi","sequence":"additional","affiliation":[{"name":"Traditional Medicine Research Center, Chinese Medicine Confucius Institute at Hyogo College of Medicine (CMCIHCM), Kobe, Japan"},{"name":"Department of Anatomy and Neuroscience, Hyogo College of Medicine, Nishinomiya, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1349-9886","authenticated-orcid":false,"given":"Yi","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, School of Pharmacy, Hyogo University of Health Sciences, Kobe, Japan"},{"name":"Traditional Medicine Research Center, Chinese Medicine Confucius Institute at Hyogo College of Medicine (CMCIHCM), Kobe, Japan"},{"name":"Department of Anatomy and Neuroscience, Hyogo College of Medicine, Nishinomiya, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm14165"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.02.011"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-014-1022-3"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2012-303857"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1501505"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-014-1014-3"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(94)90228-3"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2008.01178.x"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2011.00016"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-13-04891.2001"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2000.16509"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2009.03937.x"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-019-01550-4"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2007.05.015"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13304"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1038\/s41395-018-0264-8"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.11.001"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.96.09030493"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1002\/jgh3.12410"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.2174\/1876386300902010011"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R113.546218"},{"key":"B22","doi-asserted-by":"crossref","first-page":"4061","DOI":"10.4049\/jimmunol.150.9.4061","volume":"150","author":"Walker C","year":"1993","journal-title":"J Immunol"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13576"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.5056\/jnm15174"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1159\/000072059"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-008-2303-5"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.5056\/jnm.2010.16.3.251"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.05.018"},{"key":"B29","doi-asserted-by":"crossref","unstructured":"Ouchi R, Kawano T, Yoshida H, Ishii M, Miyasaka T, Ohkawara Y, Takayanagi M, Takahashi R, Ohno I. Maternal separation as early-life stress causes enhanced allergic airway responses by inhibiting respiratory tolerance in mice. 246: 155\u2013165, 2018. doi:10.1620\/tjem.246.155.","DOI":"10.1620\/tjem.246.155"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2017.01.035"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X14666151208113700"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1126\/science.1249098.Sleep"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.112940"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.5056\/jnm18176"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12292"},{"key":"B36","volume":"201","author":"Nguyen T","year":"2020","journal-title":"Am J Respir Crit Care Med"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2015.158"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izz024"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1016\/j.ando.2018.03.004"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200544010-00003"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1136\/gut.46.1.32"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2005.03976.x"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00400.2006"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-018-5343-6"}],"container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpgi.00313.2020","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T01:53:16Z","timestamp":1697075596000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpgi.00313.2020"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,1]]},"references-count":44,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2,1]]}},"alternative-id":["10.1152\/ajpgi.00313.2020"],"URL":"https:\/\/doi.org\/10.1152\/ajpgi.00313.2020","relation":{},"ISSN":["0193-1857","1522-1547"],"issn-type":[{"value":"0193-1857","type":"print"},{"value":"1522-1547","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,1]]},"assertion":[{"value":"2020-08-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-04","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}