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Compared with wild-type (WT) mice, the mPGES-1 Tg mice showed less liver hemorrhage, lower serum alanine transaminase (ALT) and aspartate transaminase (AST) levels, less hepatic necrosis\/apoptosis, and lower level of caspase cascade activation after intraperitoneal injection of the anti-Fas antibody Jo2. Western blotting analysis revealed increased expression and activation of the serine\/threonine kinase Akt and associated antiapoptotic molecules in the liver tissues of Jo2-treated mPGES-1 Tg mice. Pretreatment with the mPGES-1 inhibitor (MF63) or the Akt inhibitor (Akt inhibitor V) restored the susceptibility of the mPGES-1 Tg mice to Fas-induced liver injury. Our findings provide novel evidence that mPGES-1 prevents Fas-induced liver injury through activation of Akt and related signaling and suggest that induction of mPGES-1 or treatment with PGE<jats:sub>2<\/jats:sub>may represent important therapeutic strategy for the prevention and treatment of Fas-associated liver injuries.<\/jats:p>","DOI":"10.1152\/ajpgi.00327.2015","type":"journal-article","created":{"date-parts":[[2016,4,29]],"date-time":"2016-04-29T17:18:50Z","timestamp":1461950330000},"page":"G1071-G1080","source":"Crossref","is-referenced-by-count":10,"title":["Microsomal prostaglandin E synthase-1 protects against Fas-induced liver injury"],"prefix":"10.1152","volume":"310","author":[{"given":"Lu","family":"Yao","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Tulane University School of Medicine, New Orleans, 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