{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T11:10:33Z","timestamp":1785409833538,"version":"3.56.0"},"reference-count":47,"publisher":"American Physiological Society","issue":"5","funder":[{"DOI":"10.13039\/501100001691","name":"MEXT | Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["21K07914"],"award-info":[{"award-number":["21K07914"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"MEXT | Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["24K11388"],"award-info":[{"award-number":["24K11388"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014422","name":"Lilly | Eli Lilly Japan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014422","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"published-print":{"date-parts":[[2025,5,1]]},"abstract":"<jats:p>NASH is a type of NAFLD with severe damage such as inflammation and fibrosis, which causes hepatocellular carcinoma. This study explores macrophage-specific iron involvement in NASH using LysM-Cre FthKO mice. Results show that knocking out H-ferritin in macrophages reduces NASH-related inflammation, fibrosis, and oxidative stress compared with wild-type mice. Tumor occurrence was lower in LysM-Cre FthKO mice. These findings suggest that macrophage iron modulation may be a therapeutic target for NASH treatment.<\/jats:p>","DOI":"10.1152\/ajpgi.00328.2024","type":"journal-article","created":{"date-parts":[[2025,4,3]],"date-time":"2025-04-03T12:49:53Z","timestamp":1743684593000},"page":"G533-G544","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Deletion of H-ferritin in macrophages mitigates the development of steatohepatitis and hepatocellular carcinoma in mice"],"prefix":"10.1152","volume":"328","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4318-7349","authenticated-orcid":false,"given":"Yasumasa","family":"Ikeda","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/044vy1d05","id-type":"ROR","asserted-by":"publisher"}],"name":"Tokushima University Graduate School","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masafumi","family":"Funamoto","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/044vy1d05","id-type":"ROR","asserted-by":"publisher"}],"name":"Tokushima University Graduate School","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruka","family":"Itami","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/044vy1d05","id-type":"ROR","asserted-by":"publisher"}],"name":"Tokushima University Graduate School","place":["Japan"]},{"name":"Tokushima University Graduate School","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mizuho","family":"Yamamoto","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/044vy1d05","id-type":"ROR","asserted-by":"publisher"}],"name":"Tokushima University Graduate School","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5785-4435","authenticated-orcid":false,"given":"Hai Du","family":"Ly-Nguyen","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/044vy1d05","id-type":"ROR","asserted-by":"publisher"}],"name":"Tokushima University Graduate School","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Imanishi","sequence":"additional","affiliation":[{"name":"Tokushima University Graduate School","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2560-0227","authenticated-orcid":false,"given":"Koichiro","family":"Tsuchiya","sequence":"additional","affiliation":[{"name":"Tokushima University Graduate School","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30251"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1038\/hr.2010.60"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2023.06.003"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2014.04.014"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2022.06.012"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-018-0082-x"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1159\/000518407"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-016-4049-x"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1186\/s41232-016-0005-6"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-022-00675-6"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-05-1857"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.livres.2022.09.003"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1111\/liv.14503"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12255"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.4103\/2277-9175.200787"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.13174"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.3390\/nu11092172"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.164.12.6166"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2012.03.003"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1002\/JLB.3A0318-108R"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2020.102032"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-020-05153-0"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.03.011"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2016.05.005"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0040465"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1369\/0022155413501325"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0082163"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00246.2015"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.27184"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24038"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-21-0754"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1007\/s11894-011-0234-4"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2022.04.006"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.2337\/db07-0907"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2006.06.007"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M209649200"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.02.051"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2014.10.039"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1210\/endo.137.1.8536636"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2015-310798"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.2337\/db09-0016"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2023.166800"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2014.11.034"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2021.08.012"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2008.09.011"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1126\/science.1140485"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.31029"}],"container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpgi.00328.2024","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T13:33:08Z","timestamp":1746711188000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpgi.00328.2024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,1]]},"references-count":47,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5,1]]}},"alternative-id":["10.1152\/ajpgi.00328.2024"],"URL":"https:\/\/doi.org\/10.1152\/ajpgi.00328.2024","relation":{},"ISSN":["0193-1857","1522-1547"],"issn-type":[{"value":"0193-1857","type":"print"},{"value":"1522-1547","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,1]]},"assertion":[{"value":"2024-10-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-27","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}