{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T07:59:09Z","timestamp":1789977549694,"version":"4.0.1"},"reference-count":51,"publisher":"American Physiological Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"published-print":{"date-parts":[[2014,8,1]]},"abstract":"<jats:p>Type 2 diabetes is associated with elevated circulating levels of the chemokine RANTES and with decreased plasma levels of the incretin hormone glucagon-like peptide 1 (GLP-1). GLP-1 is a peptide secreted from intestinal L-cells upon nutrient ingestion. It enhances insulin secretion from pancreatic \u03b2-cells and protects from \u03b2-cell loss but also promotes satiety and weight loss. In search of chemokines that may reduce GLP-1 secretion we identified RANTES and show that it reduces glucose-stimulated GLP-1 secretion in the human enteroendocrine cell line NCI-H716, blocked by the antagonist Met-RANTES, and in vivo in mice. RANTES exposure to mouse intestinal tissues lowers transport function of the intestinal glucose transporter SGLT1, and administration in mice reduces plasma GLP-1 and GLP-2 levels after an oral glucose load and thereby impairs insulin secretion. These data show that RANTES is involved in altered secretion of glucagon-like peptide hormones most probably acting through SGLT1, and our study identifies the RANTES-receptor CCR1 as a potential target in diabetes therapy.<\/jats:p>","DOI":"10.1152\/ajpgi.00329.2013","type":"journal-article","created":{"date-parts":[[2014,5,30]],"date-time":"2014-05-30T05:57:22Z","timestamp":1401429442000},"page":"G330-G337","source":"Crossref","is-referenced-by-count":22,"title":["RANTES (CCL5) reduces glucose-dependent secretion of glucagon-like peptides 1 and 2 and impairs glucose-induced insulin secretion in mice"],"prefix":"10.1152","volume":"307","author":[{"given":"Ramona","family":"Pais","sequence":"first","affiliation":[{"name":"ZIEL Research Center of Nutrition and Food Sciences, Nutritional Medicine, Technische Universit\u00e4t M\u00fcnchen, Freising, Germany;"},{"name":"ZIEL Research Center of Nutrition and Food Sciences, Abteilung Biochemie, Technische Universit\u00e4t M\u00fcnchen, Freising, Germany; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara","family":"Zietek","sequence":"additional","affiliation":[{"name":"ZIEL Research Center of Nutrition and Food Sciences, Abteilung Biochemie, Technische Universit\u00e4t M\u00fcnchen, Freising, Germany; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Hauner","sequence":"additional","affiliation":[{"name":"ZIEL Research Center of Nutrition and Food Sciences, Nutritional Medicine, Technische Universit\u00e4t M\u00fcnchen, Freising, Germany;"},{"name":"Klinikum rechts der Isar, Technische Universit\u00e4t M\u00fcnchen, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannelore","family":"Daniel","sequence":"additional","affiliation":[{"name":"ZIEL Research Center of Nutrition and Food Sciences, Abteilung Biochemie, Technische Universit\u00e4t M\u00fcnchen, Freising, Germany; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Skurk","sequence":"additional","affiliation":[{"name":"ZIEL Research Center of Nutrition and Food Sciences, Nutritional Medicine, Technische Universit\u00e4t M\u00fcnchen, Freising, Germany;"},{"name":"Klinikum rechts der Isar, Technische Universit\u00e4t M\u00fcnchen, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.166.1.552"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.52.2.252"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2005.034983"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1042\/bj20020393"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1210\/endo.139.10.6228"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200324285"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1997.273.6.R1965"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.12.15.1693"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.1999.00978.x"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-013-3037-3"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2006.01.004"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.2174\/1381612013397401"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.2337\/dc07-0228"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.26.10.2929"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.11.3953"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.15.7911"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2513"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2010.01107.x"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1111\/j.1549-8719.2011.00084.x"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.2337\/db11-1029"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.54.suppl_2.S11"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0706890104"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.nutr.28.061807.155518"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.109.197442"},{"key":"B25","author":"Kim K","journal-title":"Arch Pharm Res"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-013-3022-x"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-0115(99)00089-0"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1084\/jem.178.6.1913"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00412.2009"},{"key":"B30","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1128\/JVI.72.1.830-836.1998","volume":"72","author":"Naif HM","year":"1998","journal-title":"J Virol"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1007\/BF02427280"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-63-2-492"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.2000.01324.x"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2008.03.458"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.5.2599"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.51.9.2757"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2011.12.019"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1677\/joe.1.06557"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1210\/endo.142.10.8415"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0089977"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1038\/347669a0"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-007-0750-9"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1093345"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4141(200107)31:7<2170::AID-IMMU2170>3.0.CO;2-D"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200324166"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.86.8.7750"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.2337\/db11-1019"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1210\/en.2010-0956"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.2337\/db11-1065"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.638379"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1096\/fj.02-0962fje"}],"container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajpgi.00329.2013","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,20]],"date-time":"2020-08-20T09:55:21Z","timestamp":1597917321000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajpgi.00329.2013"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8,1]]},"references-count":51,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,8,1]]}},"alternative-id":["10.1152\/ajpgi.00329.2013"],"URL":"https:\/\/doi.org\/10.1152\/ajpgi.00329.2013","relation":{},"ISSN":["0193-1857","1522-1547"],"issn-type":[{"value":"0193-1857","type":"print"},{"value":"1522-1547","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,1]]}}}