{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T05:06:33Z","timestamp":1791090393184,"version":"4.1.0"},"reference-count":39,"publisher":"American Physiological Society","issue":"5","funder":[{"DOI":"10.13039\/501100004396","name":"Thailand Research Fund","doi-asserted-by":"publisher","award":["RES_61_202_30_022"],"award-info":[{"award-number":["RES_61_202_30_022"]}],"id":[{"id":"10.13039\/501100004396","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ratchadaphiseksomphot Endowment Fund 2017","award":["76001-HR"],"award-info":[{"award-number":["76001-HR"]}]},{"name":"Thailand Government Fund","award":["RSA-6080023"],"award-info":[{"award-number":["RSA-6080023"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"published-print":{"date-parts":[[2020,5,1]]},"abstract":"<jats:p> Although the impact of iron accumulation in several organs of patients with thalassemia is well known, the adverse effect of iron accumulation in gut is not frequently mentioned. Here, we demonstrated iron-induced gut-permeability defect, impact of organismal molecules from gut translocation of, and macrophage functional defect upon the increased sepsis susceptibility in thalassemia mice. <\/jats:p>","DOI":"10.1152\/ajpgi.00337.2019","type":"journal-article","created":{"date-parts":[[2020,4,20]],"date-time":"2020-04-20T09:52:43Z","timestamp":1587376363000},"page":"G966-G979","source":"Crossref","is-referenced-by-count":55,"title":["Gut leakage enhances sepsis susceptibility in iron-overloaded \u03b2-thalassemia mice through macrophage hyperinflammatory responses"],"prefix":"10.1152","volume":"318","author":[{"given":"Peerapat","family":"Visitchanakun","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Department of Microbiology, Chulalongkorn University, Bangkok, Thailand"},{"name":"Medical Microbiology, Interdisciplinary Program, Graduate School, Chulalongkorn University, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilasinee","family":"Saisorn","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Microbiology, Chulalongkorn University, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jutamas","family":"Wongphoom","sequence":"additional","affiliation":[{"name":"Department of Pathology, King Chulalongkorn Memorial Hospital, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piraya","family":"Chatthanathon","sequence":"additional","affiliation":[{"name":"Faculty of Science, Department of Microbiology, Chulalongkorn University, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naraporn","family":"Somboonna","sequence":"additional","affiliation":[{"name":"Faculty of Science, Department of Microbiology, Chulalongkorn University, Bangkok, Thailand"},{"name":"Microbiome Research Unit for Probiotics in Food and Cosmetics, Chulalongkorn University, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saovaros","family":"Svasti","sequence":"additional","affiliation":[{"name":"Thalassemia Research Center, Institute of Molecular Biosciences, Mahidol University, Nakornpathom, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suthat","family":"Fucharoen","sequence":"additional","affiliation":[{"name":"Thalassemia Research Center, Institute of Molecular Biosciences, Mahidol University, Nakornpathom, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5566-6403","authenticated-orcid":false,"given":"Asada","family":"Leelahavanichkul","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Microbiology, Chulalongkorn University, Bangkok, Thailand"},{"name":"Translational Research in Inflammation and Immunology Research Unit, Department of Microbiology, Chulalongkorn University, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-019-05581-y"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00879-11"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2008.346"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2016.12.002"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2018.06.019"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtemb.2018.01.002"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-553X.2012.01446.x"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/1043-4666(93)90020-6"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0000000000001339"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1159\/000486321"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2007.04.007"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V128.22.200.200"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2011.261"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00238.2014"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0000000000000645"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.12.6643"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V92.7.2511"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2015-009968"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20061354"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0181439"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00700-17"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0000000000000896"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2019.1662712"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-08-300335"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1097\/MOH.0b013e32832990a4"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.12865\/CHSJ.40.01.13"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/803237"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.01541-09"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-07-730135"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.3390\/ph11040137"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2017.1.265"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2015.09.001"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-57275-0"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(06)70437-6"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1089\/107999099314243"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.013284"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1177\/0300985814559404"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.3390\/ph11040098"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1038\/s41426-018-0202-2"}],"container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpgi.00337.2019","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,6]],"date-time":"2020-05-06T15:24:15Z","timestamp":1588778655000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpgi.00337.2019"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,1]]},"references-count":39,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,5,1]]}},"alternative-id":["10.1152\/ajpgi.00337.2019"],"URL":"https:\/\/doi.org\/10.1152\/ajpgi.00337.2019","relation":{},"ISSN":["0193-1857","1522-1547"],"issn-type":[{"value":"0193-1857","type":"print"},{"value":"1522-1547","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,1]]}}}