{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T20:39:09Z","timestamp":1767904749183,"version":"3.49.0"},"reference-count":53,"publisher":"American Physiological Society","issue":"1","funder":[{"DOI":"10.13039\/501100001691","name":"MEXT | Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP17H03932"],"award-info":[{"award-number":["JP17H03932"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"MEXT | Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP17K15557"],"award-info":[{"award-number":["JP17K15557"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"MEXT | Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP20H03148"],"award-info":[{"award-number":["JP20H03148"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"MEXT | Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP20K16120"],"award-info":[{"award-number":["JP20K16120"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"published-print":{"date-parts":[[2022,7,1]]},"abstract":"<jats:p> We found that intrathecally administered substance P enhanced colorectal motility in anesthetized rats. Neurokinin (NK) 1 receptors, but not NK2 receptors, were detected in preganglionic neurons of the pelvic nerves. Blockade of NK1 receptors in the spinal cord attenuated the enhanced colorectal motility in response to intracolonic noxious stimuli. The findings indicate that substance P may function as a neurotransmitter in the spinal reflex pathway controlling defecation. <\/jats:p>","DOI":"10.1152\/ajpgi.00342.2021","type":"journal-article","created":{"date-parts":[[2022,4,26]],"date-time":"2022-04-26T12:00:50Z","timestamp":1650974450000},"page":"G21-G30","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Intrathecally administered substance P activated the spinal defecation center and enhanced colorectal motility in anesthetized rats"],"prefix":"10.1152","volume":"323","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8599-2528","authenticated-orcid":false,"given":"Kiyotada","family":"Naitou","sequence":"first","affiliation":[{"name":"Department of Basic Veterinary Science, Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Honoka","family":"Iwashita","sequence":"additional","affiliation":[{"name":"Department of Basic Veterinary Science, Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiromi H.","family":"Ueda","sequence":"additional","affiliation":[{"name":"Department of Basic Veterinary Science, Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuya","family":"Shiraishi","sequence":"additional","affiliation":[{"name":"Department of Basic Veterinary Science, Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshikazu","family":"Fujimoto","sequence":"additional","affiliation":[{"name":"Transboundary Animal Diseases Research Center, Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiro","family":"Horii","sequence":"additional","affiliation":[{"name":"Department of Basic Veterinary Science, Laboratory of Physiology, The United Graduate School of Veterinary Sciences, Gifu University, Gifu, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoya","family":"Sawamura","sequence":"additional","affiliation":[{"name":"Department of Basic Veterinary Science, Laboratory of Physiology, The United Graduate School of Veterinary Sciences, Gifu University, Gifu, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiko","family":"Shiina","sequence":"additional","affiliation":[{"name":"Department of Basic Veterinary Science, Laboratory of Physiology, The United Graduate School of Veterinary Sciences, Gifu University, Gifu, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7368-6398","authenticated-orcid":false,"given":"Yasutake","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Basic Veterinary Science, Laboratory of Physiology, The United Graduate School of Veterinary Sciences, Gifu University, Gifu, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2015.163"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2006.116160"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1038\/srep12623"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1113\/JP272073"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13183"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1007\/s12576-017-0524-1"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-80020-x"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00317.2017"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00062.2019"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1113\/JP279942"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1993.73.2.229"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/1357-2725(96)00017-9"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2011.01649_1.x"},{"key":"B14","first-page":"968","volume":"259","author":"Ingi T","year":"1991","journal-title":"J Pharmacol Exp Ther"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/s0301-0082(98)00048-3"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00178.2018"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(83)90079-3"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/0196-9781(94)90063-9"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2004.00605.x"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12492"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00250.2013"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1007\/BF00582627"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2010.01553.x"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms4230"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1002\/cne.22723"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1111\/cns.12993"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-198904000-00012"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-199005000-00008"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1007\/BF00260610"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(95)00558-7"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.2000.00950.x"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1113\/eph8702351"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1007\/s004410050002"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(80)90069-5"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1016\/0306-3623(88)90157-7"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1515\/revneuro-2017-0102"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902260207"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(97)00548-4"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(96)01337-3"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.21-10-03656.2001"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(84)90175-1"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902850102"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.90653.2008"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.14-12-07655.1994"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.3340\/jkns.2007.42.6.462"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(82)91128-3"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2000.16484"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(20)30217-X"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.11.061"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.02.031"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.07.024"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-0618(00)00115-0"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.01.037"}],"container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpgi.00342.2021","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,8]],"date-time":"2022-06-08T13:49:15Z","timestamp":1654696155000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpgi.00342.2021"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,1]]},"references-count":53,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,7,1]]}},"alternative-id":["10.1152\/ajpgi.00342.2021"],"URL":"https:\/\/doi.org\/10.1152\/ajpgi.00342.2021","relation":{},"ISSN":["0193-1857","1522-1547"],"issn-type":[{"value":"0193-1857","type":"print"},{"value":"1522-1547","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,1]]},"assertion":[{"value":"2021-12-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-01","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}