{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T19:29:30Z","timestamp":1793042970832,"version":"4.5.0"},"reference-count":73,"publisher":"American Physiological Society","issue":"6","funder":[{"DOI":"10.13039\/501100001843","name":"DST | Science and Engineering Research Board","doi-asserted-by":"publisher","award":["CRG\/2019\/002597"],"award-info":[{"award-number":["CRG\/2019\/002597"]}],"id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014128","name":"DBT | Centre for DNA Fingerprinting and Diagnostics","doi-asserted-by":"publisher","award":["Core Fund"],"award-info":[{"award-number":["Core Fund"]}],"id":[{"id":"10.13039\/501100014128","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001501","name":"University Grants Commission","doi-asserted-by":"publisher","award":["Junior and Senior Research Fellowships"],"award-info":[{"award-number":["Junior and Senior Research Fellowships"]}],"id":[{"id":"10.13039\/501100001501","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"published-print":{"date-parts":[[2026,6,1]]},"abstract":"<jats:p>\n                    Through detailed phenotypic analysis of Ip6k1\n                    <jats:sup>\u2212<\/jats:sup>\n                    <jats:sup>\/<\/jats:sup>\n                    <jats:sup>\u2212<\/jats:sup>\n                    mice and mechanistic studies, we identify IP6K1 as a key regulator of digestive enzyme granule biogenesis and secretion in gastric glands. IP6K1 is shown to act via its specific interactor, the proteoglycan syndecan-4 (SDC4), to mediate pepsinogen C granule biogenesis. By extending IP6K1\u2019s functional landscape into gastrointestinal biology, our study opens new avenues for understanding its impact on digestion and metabolic health.\n                  <\/jats:p>","DOI":"10.1152\/ajpgi.00342.2025","type":"journal-article","created":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T14:21:17Z","timestamp":1777472477000},"page":"G684-G702","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["IP6K1 interacts with the syndecan SDC4 to support secretory granule biogenesis in gastric chief cells"],"prefix":"10.1152","volume":"330","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-0287-9047","authenticated-orcid":false,"given":"Jayraj","family":"Sen","sequence":"first","affiliation":[{"name":"BRIC-Centre for DNA Fingerprinting and Diagnostics (CDFD)","place":["India"]},{"name":"Regional Centre for Biotechnology","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5408-8534","authenticated-orcid":false,"given":"Pranjali","family":"Pore","sequence":"additional","affiliation":[{"name":"BRIC-Centre for DNA Fingerprinting and Diagnostics (CDFD)","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3101-0204","authenticated-orcid":false,"given":"Rashna","family":"Bhandari","sequence":"additional","affiliation":[{"name":"BRIC-Centre for DNA Fingerprinting and Diagnostics (CDFD)","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/s0960-9822(00)80055-x"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1111\/febs.12575"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1007\/s41745-016-0011-3"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M106842200"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2024.107116"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.396556"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1424642112"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1042\/BCJ20160610"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0909176106"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1521600113"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2020.101000"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2016.04.011"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1700165114"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1309699110"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.259117"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0712227105"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.204966"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2023.119596"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-25468-8"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1126\/science.1146824"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2018.03.001"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.11.032"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2021.101364"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-021-00468-7"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23042059"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-01-481549"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aal4045"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1080\/19768354.2022.2029560"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1186\/s13041-020-00615-3"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.3390\/biom13091317"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1002\/path.2440"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1126\/science.1260419"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx1158"},{"key":"B34","first-page":"1051","volume-title":"Anatomy and Physiology","author":"Betts JG","year":"2013"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00016.2019"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198601000-00006"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1097\/MOG.0000000000000308"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1097\/MCO.0b013e3280177687"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.22.03.0048"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(92)90124-h"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0029(20000301)48:5<293::AID-JEMT6>3.3.CO;2-1"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.124636"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.21769\/BioProtoc.2654"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1016\/j.xpro.2021.100331"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1092360202"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-024-01613-5"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1172\/JCI85510"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23158815"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.109336"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkab1030"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.90597.2008"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1152\/ajplegacy.1964.206.4.783"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-9440(10)64635-4"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2024.08.005"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.04.011"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1417900111"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20240792"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1111\/febs.13940"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2502"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2019.08.014"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2016.06.018"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.2021.35.S1.02713"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2020187118"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2016.11.010"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1016\/s0092-8674(03)00640-8"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00031.2002"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.01328-09"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1007\/400_2009_31"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2013.00101"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2006.06.010"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1016\/s0896-6273(01)00384-1"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2022.926794"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2023.1243038"}],"container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpgi.00342.2025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T17:30:25Z","timestamp":1782149425000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpgi.00342.2025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,1]]},"references-count":73,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6,1]]}},"alternative-id":["10.1152\/ajpgi.00342.2025"],"URL":"https:\/\/doi.org\/10.1152\/ajpgi.00342.2025","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2025.09.17.676719","asserted-by":"object"}]},"ISSN":["0193-1857","1522-1547"],"issn-type":[{"value":"0193-1857","type":"print"},{"value":"1522-1547","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,1]]},"assertion":[{"value":"2025-10-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-19","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}