{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T12:38:25Z","timestamp":1768826305171,"version":"3.49.0"},"reference-count":50,"publisher":"American Physiological Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"published-print":{"date-parts":[[2016,1,1]]},"abstract":"<jats:p> Podoplanin\/gp38<jats:sup>+<\/jats:sup> stromal cells present in lymphoid organs play a central role in the formation and reorganization of the extracellular matrix and in the functional regulation of immune responses. Gp38<jats:sup>+<\/jats:sup> cells are present during embryogenesis and in human livers of primary biliary cirrhosis. Since little is known about their function, we studied gp38<jats:sup>+<\/jats:sup> cells during chronic liver inflammation in models of biliary and parenchymal liver fibrosis and steatohepatitis. Gp38<jats:sup>+<\/jats:sup> cells were analyzed using flow cytometry and confocal microscopy, and the expression of their steady state and inflammation-associated genes was evaluated from healthy and inflamed livers. Gp38<jats:sup>+<\/jats:sup> cells significantly expanded in all three models of liver injury and returned to baseline levels during regression of inflammation. Based on CD133 and gp38 expression in the CD45<jats:sup>\u2212<\/jats:sup>CD31<jats:sup>\u2212<\/jats:sup>Asgpr1<jats:sup>\u2212<\/jats:sup> liver cell fraction, numerous subsets could be identified that were negative for CD133 (gp38<jats:sup>hi<\/jats:sup>CD133<jats:sup>\u2212<\/jats:sup>, gp38<jats:sup>low<\/jats:sup>CD133<jats:sup>\u2212<\/jats:sup>, and gp38<jats:sup>\u2212<\/jats:sup>CD133<jats:sup>\u2212<\/jats:sup>). Moreover, among the CD133<jats:sup>+<\/jats:sup> cells, previously identified as progenitor population in injured liver, two subpopulations could be distinguished based on their gp38 expression (gp38<jats:sup>\u2212<\/jats:sup>CD133<jats:sup>+<\/jats:sup> and CD133<jats:sup>+<\/jats:sup>gp38<jats:sup>+<\/jats:sup>). Importantly, the distribution of the identified subsets in inflammation illustrated injury-specific changes. Moreover, the gp38<jats:sup>+<\/jats:sup>CD133<jats:sup>+<\/jats:sup> cells exhibited liver progenitor cell characteristics similar to the gp38<jats:sup>\u2212<\/jats:sup>CD133<jats:sup>+<\/jats:sup> population, thus representing a novel subset within the classical progenitor cell niche. Additionally, these cells expressed distinct sets of inflammatory genes during liver injury. Our study illuminates a novel classification of the stromal\/progenitor cell compartment in the liver and pinpoints a hitherto unrecognized injury-related alteration in progenitor subset composition in chronic liver inflammation and fibrosis. <\/jats:p>","DOI":"10.1152\/ajpgi.00344.2015","type":"journal-article","created":{"date-parts":[[2015,11,12]],"date-time":"2015-11-12T21:48:40Z","timestamp":1447364920000},"page":"G1-G12","source":"Crossref","is-referenced-by-count":18,"title":["Podoplanin discriminates distinct stromal cell populations and a novel progenitor subset in the liver"],"prefix":"10.1152","volume":"310","author":[{"given":"Christoph","family":"Eckert","sequence":"first","affiliation":[{"name":"Department of Medicine II, Saarland University Medical Center, Homburg, Germany;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong Ook","family":"Kim","sequence":"additional","affiliation":[{"name":"Institute of Translational Immunology and Research Center for 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