{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T23:49:59Z","timestamp":1791848999167,"version":"4.3.4"},"reference-count":67,"publisher":"American Physiological Society","issue":"3","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100007747","name":"University of Utah","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007747","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["20PRE35110066"],"award-info":[{"award-number":["20PRE35110066"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["T32 HL144449"],"award-info":[{"award-number":["T32 HL144449"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["17POST33670663"],"award-info":[{"award-number":["17POST33670663"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008460","name":"HHS | NIH | National Center for Complementary and Integrative Health","doi-asserted-by":"publisher","award":["R01AT010247"],"award-info":[{"award-number":["R01AT010247"]}],"id":[{"id":"10.13039\/100008460","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005825","name":"USDA | National Institute of Food and Agriculture","doi-asserted-by":"publisher","award":["2019-67017-29253"],"award-info":[{"award-number":["2019-67017-29253"]}],"id":[{"id":"10.13039\/100005825","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["16GRNT31050004"],"award-info":[{"award-number":["16GRNT31050004"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["RO3AGO52848"],"award-info":[{"award-number":["RO3AGO52848"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["RO1HL141540"],"award-info":[{"award-number":["RO1HL141540"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"published-print":{"date-parts":[[2026,3,1]]},"abstract":"<jats:p>It is unknown whether exercise training, if started late-in-life, reestablishes a beneficial and cooperative intestinal microbiome. Here we demonstrate that a 12-wk treadmill running program in older mice rejuvenates the gut microbiome and attenuates markers of cardiovascular disease (CVD) risk. Notably, specific microbial taxa correlate with activity-induced improvements in overall myocardial performance and inflammation, highlighting the importance of gut health on CVD and illustrating the restorative benefits that can be attained from a low-cost lifestyle intervention.<\/jats:p>","DOI":"10.1152\/ajpgi.00354.2025","type":"journal-article","created":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T17:00:03Z","timestamp":1770138003000},"page":"G280-G292","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Late-in-life treadmill training mitigates gut microbiome imbalances and cardiovascular disease risk in mice"],"prefix":"10.1152","volume":"330","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4461-6945","authenticated-orcid":false,"given":"Jae Min","family":"Cho","sequence":"first","affiliation":[{"name":"University of Utah","place":["United States"]},{"name":"University of Utah School of Medicine","place":["United States"]},{"name":"University of California","place":["United States"]},{"name":"Greater Los Angeles VA Healthcare System","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seul-Ki","family":"Park","sequence":"additional","affiliation":[{"name":"University of Utah","place":["United States"]},{"name":"University of Utah School of Medicine","place":["United States"]},{"name":"University of California","place":["United States"]},{"name":"Greater Los Angeles VA Healthcare System","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adhini Kuppuswamy","family":"Satheesh Babu","sequence":"additional","affiliation":[{"name":"University of Utah","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sohom","family":"Mookherjee","sequence":"additional","affiliation":[{"name":"University of Utah","place":["United States"]},{"name":"University of Utah School of Medicine","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Hansen","sequence":"additional","affiliation":[{"name":"University of Utah","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chrissa","family":"Petersen","sequence":"additional","affiliation":[{"name":"University of Utah","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhong","sequence":"additional","affiliation":[{"name":"University of Arkansas for Medical Sciences","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thunder","family":"Jalili","sequence":"additional","affiliation":[{"name":"University of Utah","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7119-6301","authenticated-orcid":false,"suffix":"2nd","given":"Michael S.","family":"Robeson","sequence":"additional","affiliation":[{"name":"University of Arkansas for Medical Sciences","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umesh D.","family":"Wankhade","sequence":"additional","affiliation":[{"name":"University of Arkansas for Medical Sciences","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8424-5421","authenticated-orcid":false,"given":"Pon Velayutham","family":"Anandh Babu","sequence":"additional","affiliation":[{"name":"University of Utah","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2021-4770","authenticated-orcid":false,"given":"J. David","family":"Symons","sequence":"additional","affiliation":[{"name":"University of Utah","place":["United States"]},{"name":"University of Utah School of Medicine","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2017.12.010"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.11.024"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2016.1256525"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.3233\/NHA-170030"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0188551"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114515001786"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2011.4179"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2000.88.2.433"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01168.2002"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2009.178822"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2017.11.016"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.3390\/nu11040868"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.13935"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.3390\/nu14163293"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0125889"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1113\/JP270818"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1111\/acel.13467"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1113\/JP277336"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvac061"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-025-01650-5"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01200.2009"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2017.10.001"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvae023"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/j.ihj.2015.06.022"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.202200112"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2024.2446375"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1002\/biof.2014"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2276"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-0716-1398-6_40"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-019-0209-9"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1009581"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-018-0470-z"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkm864"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1128\/mSystems.00021-18"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-17041-7"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.156295.1"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-28034-z"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.21203\/rs.3.rs-1062191\/v1"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2015.05.011"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.822403"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcm.2009.12.004"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.111.246140"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.115.002767"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.120.14759"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.11.055"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1109400"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1238-8"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1038\/sj.embor.7400731"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2012.156"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.j831"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.03142"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2022.114057"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1186\/s12866-016-0708-5"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2016.04.016"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2009.04.002"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0247039"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-017-0320-4"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.3390\/nu9080792"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2020.1848158"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-65740-4"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.15848"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.4196\/kjpp.2021.25.6.575"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-021-01189-5"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0092193"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0150502"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01077.2014"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1538\/expanim.20-0158"}],"container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpgi.00354.2025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T20:33:30Z","timestamp":1774557210000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpgi.00354.2025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,1]]},"references-count":67,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3,1]]}},"alternative-id":["10.1152\/ajpgi.00354.2025"],"URL":"https:\/\/doi.org\/10.1152\/ajpgi.00354.2025","relation":{},"ISSN":["0193-1857","1522-1547"],"issn-type":[{"value":"0193-1857","type":"print"},{"value":"1522-1547","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,1]]},"assertion":[{"value":"2025-10-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-03","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}