{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T02:31:51Z","timestamp":1771468311000,"version":"3.50.1"},"reference-count":43,"publisher":"American Physiological Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"published-print":{"date-parts":[[2020,10,1]]},"abstract":"<jats:p> Our findings suggest that duodenal-jejunal bypass can reverse, independently of weight loss, ectopic fat deposition and insulin resistance, two features of nonalcoholic fatty liver disease that share a mutual pathway, in which perilipin-2 seems to be the main player. Our study supports further investigation into the role of proximal small intestine exclusion in the pathophysiology of nonalcoholic fatty liver disease to uncover less invasive treatments that mimic the effects of metabolic surgery and aims to prevent and treat metabolic liver disease. <\/jats:p>","DOI":"10.1152\/ajpgi.00357.2019","type":"journal-article","created":{"date-parts":[[2020,8,19]],"date-time":"2020-08-19T15:06:54Z","timestamp":1597849614000},"page":"G502-G511","source":"Crossref","is-referenced-by-count":14,"title":["Duodenal-jejunal bypass improves nonalcoholic fatty liver disease independently of weight loss in rodents with diet-induced obesity"],"prefix":"10.1152","volume":"319","author":[{"given":"Giulia","family":"Angelini","sequence":"first","affiliation":[{"name":"Fondazione Policlinico Universitario A. Gemelli Istituto di Ricovero e Cura a Carattere Scientifico, Universit\u00e0 Cattolica del S. Cuore, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lidia","family":"Castagneto-Gissey","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, Sapienza University of Rome, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Casella-Mariolo","sequence":"additional","affiliation":[{"name":"Department of Surgery, Azienda Ospedaliera S. Camillo Forlanini, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Emiliana","family":"Caristo","sequence":"additional","affiliation":[{"name":"Fondazione Policlinico Universitario A. Gemelli Istituto di Ricovero e Cura a Carattere Scientifico, Universit\u00e0 Cattolica del S. Cuore, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Francesca","family":"Russo","sequence":"additional","affiliation":[{"name":"Fondazione Policlinico Universitario A. Gemelli Istituto di Ricovero e Cura a Carattere Scientifico, Universit\u00e0 Cattolica del S. Cuore, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erminia","family":"Lembo","sequence":"additional","affiliation":[{"name":"Fondazione Policlinico Universitario A. Gemelli Istituto di Ricovero e Cura a Carattere Scientifico, Universit\u00e0 Cattolica del S. Cuore, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ornella","family":"Verrastro","sequence":"additional","affiliation":[{"name":"Fondazione Policlinico Universitario A. Gemelli Istituto di Ricovero e Cura a Carattere Scientifico, Universit\u00e0 Cattolica del S. Cuore, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianluigi","family":"Stefanizzi","sequence":"additional","affiliation":[{"name":"Fondazione Policlinico Universitario A. Gemelli Istituto di Ricovero e Cura a Carattere Scientifico, Universit\u00e0 Cattolica del S. Cuore, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pier Luigi","family":"Marini","sequence":"additional","affiliation":[{"name":"Department of Surgery, Azienda Ospedaliera S. Camillo Forlanini, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Casella","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, Sapienza University of Rome, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan R.","family":"Bornstein","sequence":"additional","affiliation":[{"name":"Department of Medicine III, Universit\u00e4tsklinikum Carl Gustav Carus an der Technischen Universit\u00e4t Dresden, Dresden, Germany"},{"name":"Diabetes and Nutritional Sciences, King's College London, London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Rubino","sequence":"additional","affiliation":[{"name":"Diabetes and Nutritional Sciences, King's College London, London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geltrude","family":"Mingrone","sequence":"additional","affiliation":[{"name":"Fondazione Policlinico Universitario A. Gemelli Istituto di Ricovero e Cura a Carattere Scientifico, Universit\u00e0 Cattolica del S. Cuore, Rome, Italy"},{"name":"Diabetes and Nutritional Sciences, King's College London, London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-53702-4"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-018-0069-8"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx684"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2013.41"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00419.x"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.2337\/db16-0039"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26672"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1001\/jama.292.14.1724"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2008.09.041"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2019.07.069"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.2337\/dc16-0686"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M004515"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2016.09.001"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.soard.2018.12.002"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.2337\/db15-0214"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1326.2010.01275.x"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.2337\/db12-0206"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.02.046"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1038\/ncb3166"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.01.042"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200421341"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2019.2248"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.04.014"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.2010.326"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000183349.16877.84"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2010.234708"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M116.759795"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2016.2317"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(13)70218-3"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-0352"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2005.12.121"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0705408104"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000002397"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000224726.61448.1b"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24376"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1011035"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00422.2010"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23594"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.90204.2008"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1016\/j.soard.2018.07.012"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28431"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30251"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2018.05.057"}],"container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpgi.00357.2019","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,23]],"date-time":"2020-09-23T12:34:17Z","timestamp":1600864457000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpgi.00357.2019"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,1]]},"references-count":43,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,10,1]]}},"alternative-id":["10.1152\/ajpgi.00357.2019"],"URL":"https:\/\/doi.org\/10.1152\/ajpgi.00357.2019","relation":{},"ISSN":["0193-1857","1522-1547"],"issn-type":[{"value":"0193-1857","type":"print"},{"value":"1522-1547","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,1]]}}}