{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T04:47:16Z","timestamp":1791348436401,"version":"4.3.1"},"reference-count":38,"publisher":"American Physiological Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"published-print":{"date-parts":[[2005,6]]},"abstract":"<jats:p>Immune mediators are involved in strain-specific manifestations of Helicobacter pylori infection, and the type of immune response is associated with production of PGE<jats:sub>2<\/jats:sub>, which in turn influences gastric acid secretion. Acid secretion plays a pivotal role, not only in the pattern of H. pylori-induced gastritis and its consequences, but also in nonsteroidal anti-inflammatory drug (NSAID)-induced gastropathies. Mice and their transgenic modifications are widely used in Helicobacter and eicosanoid research. Using [<jats:sup>14<\/jats:sup>C]aminopyrine accumulation and pylorus ligation, we aimed to study acid secretion in gastric gland preparations from the commonly used strains of BALB\/c and C57BL\/6 mice. We found that PGE<jats:sub>2<\/jats:sub>does not inhibit acid secretion in gastric glands from C57BL\/6 mice, in contrast to the expected antisecretory effect of PGE<jats:sub>2<\/jats:sub>observed in BALB\/c mice. In BALB\/c mice the effect of histamine and carbachol was reduced by PGE<jats:sub>2<\/jats:sub>, whereas in C57BL\/6 mice dose-response curves to these secretagogues were not affected. EP<jats:sub>3<\/jats:sub>receptors are not involved in acid secretion in C57BL\/6 mice, as confirmed by significantly lower expression of mRNA for the EP<jats:sub>3<\/jats:sub>receptor. These contrary findings are important to the interpretation of the antisecretory role of eicosanoids in BALB\/c and C57BL\/6 mouse strains and the involvement of prostanoids in the etiology of Helicobacter-induced inflammation and NSAID-induced gastropathies. We propose that the lack of antisecretory effect of PGE<jats:sub>2<\/jats:sub>observed in C57BL\/6 mice could reflect the extent of Helicobacter-induced inflammation and status of acid secretion in response to anti-inflammatory drugs.<\/jats:p>","DOI":"10.1152\/ajpgi.00364.2004","type":"journal-article","created":{"date-parts":[[2005,1,28]],"date-time":"2005-01-28T01:33:42Z","timestamp":1106876022000},"page":"G1110-G1117","source":"Crossref","is-referenced-by-count":3,"title":["Host-specific differences in the physiology of acid secretion related to prostaglandins may play a role in gastric inflammation and injury"],"prefix":"10.1152","volume":"288","author":[{"given":"Ireneusz T.","family":"Padol","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard 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