{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:12:17Z","timestamp":1790709137435,"version":"4.1.0"},"reference-count":41,"publisher":"American Physiological Society","issue":"1","funder":[{"DOI":"10.13039\/100000062","name":"HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)","doi-asserted-by":"publisher","award":["RO1DK035385"],"award-info":[{"award-number":["RO1DK035385"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"published-print":{"date-parts":[[2017,1,1]]},"DOI":"10.1152\/ajpgi.00370.2016","type":"journal-article","created":{"date-parts":[[2016,12,9]],"date-time":"2016-12-09T03:45:18Z","timestamp":1481255118000},"page":"G63-G66","source":"Crossref","is-referenced-by-count":34,"title":["Ca<sup>2+<\/sup>\/calmodulin\/MLCK pathway initiates, and RhoA\/ROCK maintains, the internal anal sphincter smooth muscle tone"],"prefix":"10.1152","volume":"312","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6731-6980","authenticated-orcid":false,"given":"Satish","family":"Rattan","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Gastroenterology &amp; Hepatology, Sidney Kimmel Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.115.010652"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1007\/s10974-004-7807-x"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2011.03.005"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(13)61367-0"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.03.056"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00115.2005"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2015.04.011"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(97)00657-1"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.111.240127"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00530.2004"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1159\/000171321"},{"key":"B12","doi-asserted-by":"crossref","first-page":"14662","DOI":"10.1016\/S0021-9258(18)42092-3","volume":"267","author":"Gong MC","year":"1992","journal-title":"J Biol Chem"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2011.01.018"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00398.2004"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.02.045"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.05.032"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00305.2004"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1023\/B:MCBI.0000021373.14288.00"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2002.029306"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(00)01654-9"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.68.040504.094707"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.2000.279.1.G201"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1042\/bj20021274"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.4196\/kjpp.2010.14.1.29"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2009.02.027"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00130.2006"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00438.2006"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.525444"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.11.016"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.03.043"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00430.2011"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00017.2015"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.108.140806"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00112.2012"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00473.2012"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00023.2003"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20071299"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.341073"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.02805"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms11358"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0705537"}],"container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajpgi.00370.2016","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,16]],"date-time":"2022-07-16T18:29:14Z","timestamp":1657996154000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajpgi.00370.2016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,1]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1,1]]}},"alternative-id":["10.1152\/ajpgi.00370.2016"],"URL":"https:\/\/doi.org\/10.1152\/ajpgi.00370.2016","relation":{},"ISSN":["0193-1857","1522-1547"],"issn-type":[{"value":"0193-1857","type":"print"},{"value":"1522-1547","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,1]]}}}