{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T11:22:44Z","timestamp":1768735364454,"version":"3.49.0"},"reference-count":57,"publisher":"American Physiological Society","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"published-print":{"date-parts":[[2012,4,1]]},"abstract":"<jats:p> We set out to determine the effect of peptide YY<jats:sub>3\u201336<\/jats:sub> (PYY<jats:sub>3\u201336<\/jats:sub>) on the gastric muscle tone in conscious rats by measuring intragastric pressure (IGP) during intragastric nutrient drink infusion. After an overnight fast, a chronically implanted gastric fistula was connected to a custom-made nutrient drink infusion system and a catheter to measure IGP. IGP was measured before and during the infusion of a nutrient drink (Nutridrink; 0.5 ml\/min) until 10 ml was infused. Rats were treated with PYY<jats:sub>3\u201336<\/jats:sub> (0, 33, and 100 pmol\u00b7kg<jats:sup>\u22121<\/jats:sup>\u00b7min<jats:sup>\u22121<\/jats:sup>) in combination with a subcutaneous injection of the Y<jats:sub>2<\/jats:sub> receptor antagonists JNJ31020028 (10 mg\/kg) or BIIE0246 (2 mg\/kg). Experiments were also performed after subdiaphragmatic vagotomy and after pretreatment with 3 ml of nutrient drink (to mimic a fed state). IGP was compared as the average IGP during nutrient infusion, represented as means \u00b1 SE and compared using ANOVA. PYY<jats:sub>3\u201336<\/jats:sub> dose dependently increased the IGP during nutrient infusion (4.7 \u00b1 0.3, 5.7 \u00b1 0.5 and 7.3 \u00b1 0.7 mmHg; P &lt; 0.01) while JNJ31020028 and BIIE0246 could block this increase [4.4 \u00b1 0.5 ( P &lt; 0.001) and 4.8 \u00b1 0.4 ( P &lt; 0.05) mmHg, respectively]. Also in vagotomized rats, PYY<jats:sub>3\u201336<\/jats:sub> was able to significantly increase the IGP during, an effect attenuated by JNJ31020028. BIIE0246 and JNJ31020028 were not able to decrease the IGP when no PYY<jats:sub>3\u201336<\/jats:sub> was administered. PYY<jats:sub>3\u201336<\/jats:sub> increased gastric tone through an Y<jats:sub>2<\/jats:sub> receptor-mediated mechanism that does not involve the vagus nerve. Y<jats:sub>2<\/jats:sub> receptor antagonists were not able to decrease gastric tone without exogenous administration of PYY<jats:sub>3\u201336<\/jats:sub>, indicating that Y<jats:sub>2<\/jats:sub> receptors do not play a crucial role in the determination of gastric tone in physiological conditions. <\/jats:p>","DOI":"10.1152\/ajpgi.00404.2011","type":"journal-article","created":{"date-parts":[[2012,1,21]],"date-time":"2012-01-21T02:04:47Z","timestamp":1327111487000},"page":"G732-G739","source":"Crossref","is-referenced-by-count":5,"title":["Role of Y<sub>2<\/sub> receptors in the regulation of gastric tone in rats"],"prefix":"10.1152","volume":"302","author":[{"given":"P.","family":"Janssen","sequence":"first","affiliation":[{"name":"Translational Research Center for Gastrointestinal Disorders, University of Leuven, Leuven, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Verschueren","sequence":"additional","affiliation":[{"name":"Translational 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