{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T17:04:36Z","timestamp":1758474276200},"reference-count":31,"publisher":"American Physiological Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"published-print":{"date-parts":[[2013,3,15]]},"abstract":"<jats:p> We aimed to define the sensorimotor characteristics of aero-digestive reflexes evoked upon midesophageal provocations in neuropathology infants. Provocative esophageal motility testing was performed in 20 neuropathology infants and 10 controls at 42.3 \u00b1 0.6 and 38.9 \u00b1 0.9 wk postmenstrual age. Data from 1,073 infusions were examined for the sensory thresholds, response frequencies, response magnitude of upper esophageal sphincter (UES) contractile reflexes, lower esophageal sphincter (LES) relaxation reflexes, and peristaltic reflexes using mixed statistical models. Threshold volumes for air and liquid in neuropathology and control infants were similar for all reflexes. Graded air- and liquid volume-dependent UES contractile reflex, LES relaxation reflex, and peristaltic reflex frequency recruitment were present in neuropathology and control subjects for the media ( P &lt; 0.0001) and the reflexes ( P &lt; 0.0001). In neuropathology infants (vs. controls), UES contractile magnitude is higher ( P &lt; 0.0001); LES relaxation reflex occurred earlier ( P = 0.008); LES nadir duration lasted longer ( P = 0.006); secondary peristalsis is the chief method of esophageal clearance ( P &lt; 0.0001); pharyngeal swallows and deglutition apneas are less frequent ( P = 0.001); proximal, midesophageal waveform magnitudes and duration are exaggerated ( P &lt; 0.008). UES contractile reflex was longer with liquid than air in both groups ( P = 0.03). We concluded that 1) perception to midesophageal provocation remains preserved in neuropathology neonates; 2) sustained and exaggerated myogenic response from afferent activation is evident by increased excitatory efferent outputs to the UES and esophageal body and increased inhibitory efferent outputs to the LES; 3) dysfunctional regulation of pharyngeal swallowing and infrequent deglutition responses indicate the possibility of impaired descending modulation and central malfunctions of brainstem and vagal nuclei. <\/jats:p>","DOI":"10.1152\/ajpgi.00404.2012","type":"journal-article","created":{"date-parts":[[2013,1,18]],"date-time":"2013-01-18T04:16:44Z","timestamp":1358482604000},"page":"G574-G582","source":"Crossref","is-referenced-by-count":6,"title":["Physiology of esophageal sensorimotor malfunctions in neonatal neurological illness"],"prefix":"10.1152","volume":"304","author":[{"given":"Sudarshan R.","family":"Jadcherla","sequence":"first","affiliation":[{"name":"Sections of 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