{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T12:16:10Z","timestamp":1753272970104,"version":"3.37.3"},"reference-count":41,"publisher":"American Physiological Society","issue":"6","funder":[{"DOI":"10.13039\/501100000357","name":"North West Cancer Research Fund (NWCR)","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000357","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Saudi Arabian Government"},{"name":"Wellcome Trust"},{"name":"Centre for Intigrative Biology"},{"DOI":"10.13039\/501100001102","name":"Cancer Council New South Wales","doi-asserted-by":"crossref","award":["1047672"],"award-info":[{"award-number":["1047672"]}],"id":[{"id":"10.13039\/501100001102","id-type":"DOI","asserted-by":"crossref"}]},{"name":"CORE\/BSG Development Grant"},{"name":"Independent Research Institute Infrastructure Support Scheme","award":["361646"],"award-info":[{"award-number":["361646"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"published-print":{"date-parts":[[2015,9,15]]},"abstract":"<jats:p>Helicobacter infection causes a chronic superficial gastritis that in some cases progresses via atrophic gastritis to adenocarcinoma. Proapoptotic bak has been shown to regulate radiation-induced apoptosis in the stomach and colon and also susceptibility to colorectal carcinogenesis in vivo. Therefore we investigated the gastric mucosal pathology following H. felis infection in bak-null mice at 6 or 48 wk postinfection. Primary gastric gland culture from bak-null mice was also used to assess the effects of bak deletion on IFN-\u03b3-, TNF-\u03b1-, or IL-1\u03b2-induced apoptosis. bak-null gastric corpus glands were longer, had increased epithelial Ki-67 expression, and contained fewer parietal and enteroendocrine cells compared with the wild type (wt). In wt mice, bak was expressed at the luminal surface of gastric corpus glands, and this increased 2 wk post- H. felis infection. Apoptotic cell numbers were decreased in bak-null corpus 6 and 48 wk following infection and in primary gland cultures following cytokine administration. Increased gastric epithelial Ki-67 labeling index was observed in C57BL\/6 mice after H. felis infection, whereas no such increase was detected in bak-null mice. More severe gastric atrophy was observed in bak-null compared with C57BL\/6 mice 6 and 48 wk postinfection, and 76% of bak-null compared with 25% of C57BL\/6 mice showed evidence of gastric dysplasia following long-term infection. Collectively, bak therefore regulates gastric epithelial cell apoptosis, proliferation, differentiation, mucosal thickness, and susceptibility to gastric atrophy and dysplasia following H. felis infection.<\/jats:p>","DOI":"10.1152\/ajpgi.00404.2014","type":"journal-article","created":{"date-parts":[[2015,7,10]],"date-time":"2015-07-10T02:44:14Z","timestamp":1436496254000},"page":"G420-G430","source":"Crossref","is-referenced-by-count":3,"title":["bak deletion stimulates gastric epithelial proliferation and enhances<i>Helicobacter felis<\/i>-induced gastric atrophy and dysplasia in mice"],"prefix":"10.1152","volume":"309","author":[{"given":"C. A.","family":"Duckworth","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. A.","family":"Abuderman","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. D.","family":"Burkitt","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. M.","family":"Williams","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. A.","family":"O'Reilly","sequence":"additional","affiliation":[{"name":"The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia; and"},{"name":"Department of Medical Biology, The University of Melbourne, Parkville, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. M.","family":"Pritchard","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.240501114"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2013.334"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-1802"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1997.7485"},{"key":"B5","first-page":"6735","volume":"52","author":"Correa P","year":"1992","journal-title":"Cancer Res"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1002\/path.1422"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.3700462"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00068.2012"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.11.036"},{"key":"B10","first-page":"696","volume":"62","author":"Fox JG","year":"2002","journal-title":"Cancer Res"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2008.84"},{"key":"B12","first-page":"1695","volume":"151","author":"Jones NL","year":"1997","journal-title":"Am J Pathol"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2010.07.014"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1126\/science.270.5233.96"},{"key":"B15","first-page":"4328","volume":"60","author":"Kondo S","year":"2000","journal-title":"Cancer Res"},{"key":"B16","first-page":"1449","volume":"149","author":"Krajewska M","year":"1996","journal-title":"Am J Pathol"},{"key":"B17","first-page":"2849","volume":"56","author":"Krajewski S","year":"1996","journal-title":"Cancer Res"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1159\/000121411"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(00)00136-2"},{"key":"B20","first-page":"3238","volume":"56","author":"Mannick EE","year":"1996","journal-title":"Cancer Res"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1002\/path.967"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1215097110"},{"key":"B23","first-page":"614","volume":"54","author":"Merritt AJ","year":"1994","journal-title":"Cancer Res"},{"key":"B24","doi-asserted-by":"crossref","first-page":"2261","DOI":"10.1242\/jcs.108.6.2261","volume":"108","author":"Merritt AJ","year":"1995","journal-title":"J Cell Sci"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1136\/gut.38.4.498"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2008.042648"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1080\/09553009014550431"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1203150"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1203729"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-7258(96)00102-7"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00391.2006"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/j.regpep.2007.09.002"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-1846"},{"key":"B34","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.4049\/jimmunol.163.3.1490","volume":"163","author":"Roth KA","year":"1999","journal-title":"J Immunol"},{"key":"B35","first-page":"53","volume":"13","author":"Sakamoto I","year":"2004","journal-title":"Int J Mol Med"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1746.2000.02147.x"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-10-4009"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(00)70412-4"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(98)70581-5"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.2000.278.1.G1"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgl035"}],"container-title":["American Journal of Physiology-Gastrointestinal and Liver Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajpgi.00404.2014","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,12]],"date-time":"2023-08-12T04:28:08Z","timestamp":1691814488000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajpgi.00404.2014"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9,15]]},"references-count":41,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,9,15]]}},"alternative-id":["10.1152\/ajpgi.00404.2014"],"URL":"https:\/\/doi.org\/10.1152\/ajpgi.00404.2014","relation":{},"ISSN":["0193-1857","1522-1547"],"issn-type":[{"type":"print","value":"0193-1857"},{"type":"electronic","value":"1522-1547"}],"subject":[],"published":{"date-parts":[[2015,9,15]]}}}